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000137640 0247_ $$2doi$$a10.1016/j.ccell.2018.08.004
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000137640 1001_ $$aArcher, Tenley C$$b0
000137640 245__ $$aProteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.
000137640 260__ $$aCambridge, Mass.$$bCell Press$$c2018
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000137640 520__ $$aThere is a pressing need to identify therapeutic targets in tumors with low mutation rates such as the malignant pediatric brain tumor medulloblastoma. To address this challenge, we quantitatively profiled global proteomes and phospho-proteomes of 45 medulloblastoma samples. Integrated analyses revealed that tumors with similar RNA expression vary extensively at the post-transcriptional and post-translational levels. We identified distinct pathways associated with two subsets of SHH tumors, and found post-translational modifications of MYC that are associated with poor outcomes in group 3 tumors. We found kinases associated with subtypes and showed that inhibiting PRKDC sensitizes MYC-driven cells to radiation. Our study shows that proteomics enables a more comprehensive, functional readout, providing a foundation for future therapeutic strategies.
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000137640 7001_ $$aEhrenberger, Tobias$$b1
000137640 7001_ $$aMundt, Filip$$b2
000137640 7001_ $$aGold, Maxwell P$$b3
000137640 7001_ $$aKrug, Karsten$$b4
000137640 7001_ $$aMah, Clarence K$$b5
000137640 7001_ $$aMahoney, Elizabeth L$$b6
000137640 7001_ $$aDaniel, Colin J$$b7
000137640 7001_ $$aLeNail, Alexander$$b8
000137640 7001_ $$aRamamoorthy, Divya$$b9
000137640 7001_ $$aMertins, Philipp$$b10
000137640 7001_ $$aMani, D. R.$$b11
000137640 7001_ $$aZhang, Hailei$$b12
000137640 7001_ $$aGillette, Michael A$$b13
000137640 7001_ $$aClauser, Karl$$b14
000137640 7001_ $$aNoble, Michael$$b15
000137640 7001_ $$aTang, Lauren C$$b16
000137640 7001_ $$aPierre-François, Jessica$$b17
000137640 7001_ $$aSilterra, Jacob$$b18
000137640 7001_ $$aJensen, James$$b19
000137640 7001_ $$aTamayo, Pablo$$b20
000137640 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b21$$udkfz
000137640 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b22$$udkfz
000137640 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b23$$udkfz
000137640 7001_ $$0P:(DE-HGF)0$$aNorthcott, Paul A$$b24
000137640 7001_ $$aSears, Rosalie C$$b25
000137640 7001_ $$aLipton, Jonathan O$$b26
000137640 7001_ $$aCarr, Steven A$$b27
000137640 7001_ $$aMesirov, Jill P$$b28
000137640 7001_ $$aPomeroy, Scott L$$b29
000137640 7001_ $$aFraenkel, Ernest$$b30
000137640 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2018.08.004$$gVol. 34, no. 3, p. 396 - 410.e8$$n3$$p396 - 410.e8$$tCancer cell$$v34$$x1535-6108$$y2018
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