TY  - JOUR
AU  - Archer, Tenley C
AU  - Ehrenberger, Tobias
AU  - Mundt, Filip
AU  - Gold, Maxwell P
AU  - Krug, Karsten
AU  - Mah, Clarence K
AU  - Mahoney, Elizabeth L
AU  - Daniel, Colin J
AU  - LeNail, Alexander
AU  - Ramamoorthy, Divya
AU  - Mertins, Philipp
AU  - Mani, D. R.
AU  - Zhang, Hailei
AU  - Gillette, Michael A
AU  - Clauser, Karl
AU  - Noble, Michael
AU  - Tang, Lauren C
AU  - Pierre-François, Jessica
AU  - Silterra, Jacob
AU  - Jensen, James
AU  - Tamayo, Pablo
AU  - Korshunov, Andrey
AU  - Pfister, Stefan
AU  - Kool, Marcel
AU  - Northcott, Paul A
AU  - Sears, Rosalie C
AU  - Lipton, Jonathan O
AU  - Carr, Steven A
AU  - Mesirov, Jill P
AU  - Pomeroy, Scott L
AU  - Fraenkel, Ernest
TI  - Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups.
JO  - Cancer cell
VL  - 34
IS  - 3
SN  - 1535-6108
CY  - Cambridge, Mass.
PB  - Cell Press
M1  - DKFZ-2018-01520
SP  - 396 - 410.e8
PY  - 2018
AB  - There is a pressing need to identify therapeutic targets in tumors with low mutation rates such as the malignant pediatric brain tumor medulloblastoma. To address this challenge, we quantitatively profiled global proteomes and phospho-proteomes of 45 medulloblastoma samples. Integrated analyses revealed that tumors with similar RNA expression vary extensively at the post-transcriptional and post-translational levels. We identified distinct pathways associated with two subsets of SHH tumors, and found post-translational modifications of MYC that are associated with poor outcomes in group 3 tumors. We found kinases associated with subtypes and showed that inhibiting PRKDC sensitizes MYC-driven cells to radiation. Our study shows that proteomics enables a more comprehensive, functional readout, providing a foundation for future therapeutic strategies.
LB  - PUB:(DE-HGF)16
C6  - pmid:30205044
DO  - DOI:10.1016/j.ccell.2018.08.004
UR  - https://inrepo02.dkfz.de/record/137640
ER  -