%0 Journal Article
%A Forget, Antoine
%A Martignetti, Loredana
%A Puget, Stéphanie
%A Calzone, Laurence
%A Brabetz, Sebastian
%A Picard, Daniel Joseph
%A Montagud, Arnau
%A Liva, Stéphane
%A Sta, Alexandre
%A Dingli, Florent
%A Arras, Guillaume
%A Rivera, Jaime
%A Loew, Damarys
%A Besnard, Aurore
%A Lacombe, Joëlle
%A Pagès, Mélanie
%A Varlet, Pascale
%A Dufour, Christelle
%A Yu, Hua
%A Mercier, Audrey L
%A Indersie, Emilie
%A Chivet, Anaïs
%A Leboucher, Sophie
%A Sieber, Laura
%A Beccaria, Kevin
%A Gombert, Michael
%A Meyer, Frauke-Dorothee
%A Qin, Nan
%A Bartl, Jasmin
%A Chavez, Lukas
%A Okonechnikov, Konstantin
%A Sharma, Tanvi
%A Thatikonda, Venu
%A Bourdeaut, Franck
%A Pouponnot, Celio
%A Ramaswamy, Vijay
%A Korshunov, Andrey
%A Borkhardt, Arndt
%A Reifenberger, Guido
%A Poullet, Patrick
%A Taylor, Michael D
%A Kool, Marcel
%A Pfister, Stefan
%A Kawauchi, Daisuke
%A Barillot, Emmanuel
%A Remke, Marc
%A Ayrault, Olivier
%T Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.
%J Cancer cell
%V 34
%N 3
%@ 1535-6108
%C Cambridge, Mass.
%I Cell Press
%M DKFZ-2018-01521
%P 379 - 395.e7
%D 2018
%X The current consensus recognizes four main medulloblastoma subgroups (wingless, Sonic hedgehog, group 3 and group 4). While medulloblastoma subgroups have been characterized extensively at the (epi-)genomic and transcriptomic levels, the proteome and phosphoproteome landscape remain to be comprehensively elucidated. Using quantitative (phospho)-proteomics in primary human medulloblastomas, we unravel distinct posttranscriptional regulation leading to highly divergent oncogenic signaling and kinase activity profiles in groups 3 and 4 medulloblastomas. Specifically, proteomic and phosphoproteomic analyses identify aberrant ERBB4-SRC signaling in group 4. Hence, enforced expression of an activated SRC combined with p53 inactivation induces murine tumors that resemble group 4 medulloblastoma. Therefore, our integrative proteogenomics approach unveils an oncogenic pathway and potential therapeutic vulnerability in the most common medulloblastoma subgroup.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30205043
%R 10.1016/j.ccell.2018.08.002
%U https://inrepo02.dkfz.de/record/137641