000137641 001__ 137641
000137641 005__ 20240229105113.0
000137641 0247_ $$2doi$$a10.1016/j.ccell.2018.08.002
000137641 0247_ $$2pmid$$apmid:30205043
000137641 0247_ $$2ISSN$$a1535-6108
000137641 0247_ $$2ISSN$$a1878-3686
000137641 0247_ $$2altmetric$$aaltmetric:48075020
000137641 037__ $$aDKFZ-2018-01521
000137641 041__ $$aeng
000137641 082__ $$a610
000137641 1001_ $$aForget, Antoine$$b0
000137641 245__ $$aAberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.
000137641 260__ $$aCambridge, Mass.$$bCell Press$$c2018
000137641 3367_ $$2DRIVER$$aarticle
000137641 3367_ $$2DataCite$$aOutput Types/Journal article
000137641 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1554367114_31790
000137641 3367_ $$2BibTeX$$aARTICLE
000137641 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000137641 3367_ $$00$$2EndNote$$aJournal Article
000137641 520__ $$aThe current consensus recognizes four main medulloblastoma subgroups (wingless, Sonic hedgehog, group 3 and group 4). While medulloblastoma subgroups have been characterized extensively at the (epi-)genomic and transcriptomic levels, the proteome and phosphoproteome landscape remain to be comprehensively elucidated. Using quantitative (phospho)-proteomics in primary human medulloblastomas, we unravel distinct posttranscriptional regulation leading to highly divergent oncogenic signaling and kinase activity profiles in groups 3 and 4 medulloblastomas. Specifically, proteomic and phosphoproteomic analyses identify aberrant ERBB4-SRC signaling in group 4. Hence, enforced expression of an activated SRC combined with p53 inactivation induces murine tumors that resemble group 4 medulloblastoma. Therefore, our integrative proteogenomics approach unveils an oncogenic pathway and potential therapeutic vulnerability in the most common medulloblastoma subgroup.
000137641 536__ $$0G:(DE-HGF)POF3-319H$$a319H - Addenda (POF3-319H)$$cPOF3-319H$$fPOF III$$x0
000137641 588__ $$aDataset connected to CrossRef, PubMed,
000137641 7001_ $$aMartignetti, Loredana$$b1
000137641 7001_ $$aPuget, Stéphanie$$b2
000137641 7001_ $$aCalzone, Laurence$$b3
000137641 7001_ $$0P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629$$aBrabetz, Sebastian$$b4$$udkfz
000137641 7001_ $$0P:(DE-He78)2d0b899984e41ffa8cb15d799d32afd1$$aPicard, Daniel Joseph$$b5$$udkfz
000137641 7001_ $$aMontagud, Arnau$$b6
000137641 7001_ $$aLiva, Stéphane$$b7
000137641 7001_ $$aSta, Alexandre$$b8
000137641 7001_ $$aDingli, Florent$$b9
000137641 7001_ $$aArras, Guillaume$$b10
000137641 7001_ $$aRivera, Jaime$$b11
000137641 7001_ $$aLoew, Damarys$$b12
000137641 7001_ $$aBesnard, Aurore$$b13
000137641 7001_ $$aLacombe, Joëlle$$b14
000137641 7001_ $$aPagès, Mélanie$$b15
000137641 7001_ $$aVarlet, Pascale$$b16
000137641 7001_ $$aDufour, Christelle$$b17
000137641 7001_ $$aYu, Hua$$b18
000137641 7001_ $$aMercier, Audrey L$$b19
000137641 7001_ $$aIndersie, Emilie$$b20
000137641 7001_ $$aChivet, Anaïs$$b21
000137641 7001_ $$aLeboucher, Sophie$$b22
000137641 7001_ $$0P:(DE-He78)a4101d4d75f0b7d1f24f67ccbe63164b$$aSieber, Laura$$b23$$udkfz
000137641 7001_ $$aBeccaria, Kevin$$b24
000137641 7001_ $$aGombert, Michael$$b25
000137641 7001_ $$0P:(DE-He78)59ffe2957ee9f9009e7d4ec650023f47$$aMeyer, Frauke-Dorothee$$b26$$udkfz
000137641 7001_ $$0P:(DE-He78)a05fe89e8d9ccc1fbd56df77464c7856$$aQin, Nan$$b27$$udkfz
000137641 7001_ $$0P:(DE-He78)0b115428d6170ebe021af308ed2a0cf1$$aBartl, Jasmin$$b28$$udkfz
000137641 7001_ $$0P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aChavez, Lukas$$b29$$udkfz
000137641 7001_ $$aOkonechnikov, Konstantin$$b30
000137641 7001_ $$0P:(DE-He78)36e1ec4777d5b7887344177dca41eae9$$aSharma, Tanvi$$b31$$udkfz
000137641 7001_ $$0P:(DE-He78)26c413e17f63cb683978f4025fcb831e$$aThatikonda, Venu$$b32$$udkfz
000137641 7001_ $$aBourdeaut, Franck$$b33
000137641 7001_ $$aPouponnot, Celio$$b34
000137641 7001_ $$aRamaswamy, Vijay$$b35
000137641 7001_ $$0P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aKorshunov, Andrey$$b36$$udkfz
000137641 7001_ $$aBorkhardt, Arndt$$b37
000137641 7001_ $$aReifenberger, Guido$$b38
000137641 7001_ $$aPoullet, Patrick$$b39
000137641 7001_ $$aTaylor, Michael D$$b40
000137641 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b41$$udkfz
000137641 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan$$b42$$udkfz
000137641 7001_ $$0P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b$$aKawauchi, Daisuke$$b43$$udkfz
000137641 7001_ $$aBarillot, Emmanuel$$b44
000137641 7001_ $$0P:(DE-He78)a244aa021112b9002419791434bbc71c$$aRemke, Marc$$b45$$udkfz
000137641 7001_ $$aAyrault, Olivier$$b46
000137641 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2018.08.002$$gVol. 34, no. 3, p. 379 - 395.e7$$n3$$p379 - 395.e7$$tCancer cell$$v34$$x1535-6108$$y2018
000137641 909CO $$ooai:inrepo02.dkfz.de:137641$$pVDB
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)2d0b899984e41ffa8cb15d799d32afd1$$aDeutsches Krebsforschungszentrum$$b5$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a4101d4d75f0b7d1f24f67ccbe63164b$$aDeutsches Krebsforschungszentrum$$b23$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)59ffe2957ee9f9009e7d4ec650023f47$$aDeutsches Krebsforschungszentrum$$b26$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a05fe89e8d9ccc1fbd56df77464c7856$$aDeutsches Krebsforschungszentrum$$b27$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0b115428d6170ebe021af308ed2a0cf1$$aDeutsches Krebsforschungszentrum$$b28$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)082dd3179733e3e716a58eb90f418a78$$aDeutsches Krebsforschungszentrum$$b29$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)36e1ec4777d5b7887344177dca41eae9$$aDeutsches Krebsforschungszentrum$$b31$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)26c413e17f63cb683978f4025fcb831e$$aDeutsches Krebsforschungszentrum$$b32$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93$$aDeutsches Krebsforschungszentrum$$b36$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aDeutsches Krebsforschungszentrum$$b41$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aDeutsches Krebsforschungszentrum$$b42$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b$$aDeutsches Krebsforschungszentrum$$b43$$kDKFZ
000137641 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)a244aa021112b9002419791434bbc71c$$aDeutsches Krebsforschungszentrum$$b45$$kDKFZ
000137641 9131_ $$0G:(DE-HGF)POF3-319H$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vAddenda$$x0
000137641 9141_ $$y2018
000137641 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCANCER CELL : 2015
000137641 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000137641 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000137641 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000137641 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000137641 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000137641 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000137641 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000137641 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000137641 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000137641 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000137641 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000137641 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000137641 915__ $$0StatID:(DE-HGF)9920$$2StatID$$aIF >= 20$$bCANCER CELL : 2015
000137641 9201_ $$0I:(DE-He78)B062-20160331$$kB062$$lPädiatrische Neuroonkologie$$x0
000137641 9201_ $$0I:(DE-He78)L401-20160331$$kL401$$lDKTK Essen$$x1
000137641 9201_ $$0I:(DE-He78)G380-20160331$$kG380$$lKKE Neuropathologie$$x2
000137641 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x3
000137641 980__ $$ajournal
000137641 980__ $$aVDB
000137641 980__ $$aI:(DE-He78)B062-20160331
000137641 980__ $$aI:(DE-He78)L401-20160331
000137641 980__ $$aI:(DE-He78)G380-20160331
000137641 980__ $$aI:(DE-He78)L101-20160331
000137641 980__ $$aUNRESTRICTED