guest ::
| Home > Publications database > Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. > print |
| Home > Publications database > Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. > print |
| 001 | 137641 | ||
| 005 | 20240229105113.0 | ||
| 024 | 7 | _ | |a 10.1016/j.ccell.2018.08.002 |2 doi |
| 024 | 7 | _ | |a pmid:30205043 |2 pmid |
| 024 | 7 | _ | |a 1535-6108 |2 ISSN |
| 024 | 7 | _ | |a 1878-3686 |2 ISSN |
| 024 | 7 | _ | |a altmetric:48075020 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-01521 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Forget, Antoine |b 0 |
| 245 | _ | _ | |a Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling. |
| 260 | _ | _ | |a Cambridge, Mass. |c 2018 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1554367114_31790 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The current consensus recognizes four main medulloblastoma subgroups (wingless, Sonic hedgehog, group 3 and group 4). While medulloblastoma subgroups have been characterized extensively at the (epi-)genomic and transcriptomic levels, the proteome and phosphoproteome landscape remain to be comprehensively elucidated. Using quantitative (phospho)-proteomics in primary human medulloblastomas, we unravel distinct posttranscriptional regulation leading to highly divergent oncogenic signaling and kinase activity profiles in groups 3 and 4 medulloblastomas. Specifically, proteomic and phosphoproteomic analyses identify aberrant ERBB4-SRC signaling in group 4. Hence, enforced expression of an activated SRC combined with p53 inactivation induces murine tumors that resemble group 4 medulloblastoma. Therefore, our integrative proteogenomics approach unveils an oncogenic pathway and potential therapeutic vulnerability in the most common medulloblastoma subgroup. |
| 536 | _ | _ | |a 319H - Addenda (POF3-319H) |0 G:(DE-HGF)POF3-319H |c POF3-319H |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Martignetti, Loredana |b 1 |
| 700 | 1 | _ | |a Puget, Stéphanie |b 2 |
| 700 | 1 | _ | |a Calzone, Laurence |b 3 |
| 700 | 1 | _ | |a Brabetz, Sebastian |0 P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629 |b 4 |u dkfz |
| 700 | 1 | _ | |a Picard, Daniel Joseph |0 P:(DE-He78)2d0b899984e41ffa8cb15d799d32afd1 |b 5 |u dkfz |
| 700 | 1 | _ | |a Montagud, Arnau |b 6 |
| 700 | 1 | _ | |a Liva, Stéphane |b 7 |
| 700 | 1 | _ | |a Sta, Alexandre |b 8 |
| 700 | 1 | _ | |a Dingli, Florent |b 9 |
| 700 | 1 | _ | |a Arras, Guillaume |b 10 |
| 700 | 1 | _ | |a Rivera, Jaime |b 11 |
| 700 | 1 | _ | |a Loew, Damarys |b 12 |
| 700 | 1 | _ | |a Besnard, Aurore |b 13 |
| 700 | 1 | _ | |a Lacombe, Joëlle |b 14 |
| 700 | 1 | _ | |a Pagès, Mélanie |b 15 |
| 700 | 1 | _ | |a Varlet, Pascale |b 16 |
| 700 | 1 | _ | |a Dufour, Christelle |b 17 |
| 700 | 1 | _ | |a Yu, Hua |b 18 |
| 700 | 1 | _ | |a Mercier, Audrey L |b 19 |
| 700 | 1 | _ | |a Indersie, Emilie |b 20 |
| 700 | 1 | _ | |a Chivet, Anaïs |b 21 |
| 700 | 1 | _ | |a Leboucher, Sophie |b 22 |
| 700 | 1 | _ | |a Sieber, Laura |0 P:(DE-He78)a4101d4d75f0b7d1f24f67ccbe63164b |b 23 |u dkfz |
| 700 | 1 | _ | |a Beccaria, Kevin |b 24 |
| 700 | 1 | _ | |a Gombert, Michael |b 25 |
| 700 | 1 | _ | |a Meyer, Frauke-Dorothee |0 P:(DE-He78)59ffe2957ee9f9009e7d4ec650023f47 |b 26 |u dkfz |
| 700 | 1 | _ | |a Qin, Nan |0 P:(DE-He78)a05fe89e8d9ccc1fbd56df77464c7856 |b 27 |u dkfz |
| 700 | 1 | _ | |a Bartl, Jasmin |0 P:(DE-He78)0b115428d6170ebe021af308ed2a0cf1 |b 28 |u dkfz |
| 700 | 1 | _ | |a Chavez, Lukas |0 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |b 29 |u dkfz |
| 700 | 1 | _ | |a Okonechnikov, Konstantin |b 30 |
| 700 | 1 | _ | |a Sharma, Tanvi |0 P:(DE-He78)36e1ec4777d5b7887344177dca41eae9 |b 31 |u dkfz |
| 700 | 1 | _ | |a Thatikonda, Venu |0 P:(DE-He78)26c413e17f63cb683978f4025fcb831e |b 32 |u dkfz |
| 700 | 1 | _ | |a Bourdeaut, Franck |b 33 |
| 700 | 1 | _ | |a Pouponnot, Celio |b 34 |
| 700 | 1 | _ | |a Ramaswamy, Vijay |b 35 |
| 700 | 1 | _ | |a Korshunov, Andrey |0 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |b 36 |u dkfz |
| 700 | 1 | _ | |a Borkhardt, Arndt |b 37 |
| 700 | 1 | _ | |a Reifenberger, Guido |b 38 |
| 700 | 1 | _ | |a Poullet, Patrick |b 39 |
| 700 | 1 | _ | |a Taylor, Michael D |b 40 |
| 700 | 1 | _ | |a Kool, Marcel |0 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |b 41 |u dkfz |
| 700 | 1 | _ | |a Pfister, Stefan |0 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |b 42 |u dkfz |
| 700 | 1 | _ | |a Kawauchi, Daisuke |0 P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b |b 43 |u dkfz |
| 700 | 1 | _ | |a Barillot, Emmanuel |b 44 |
| 700 | 1 | _ | |a Remke, Marc |0 P:(DE-He78)a244aa021112b9002419791434bbc71c |b 45 |u dkfz |
| 700 | 1 | _ | |a Ayrault, Olivier |b 46 |
| 773 | _ | _ | |a 10.1016/j.ccell.2018.08.002 |g Vol. 34, no. 3, p. 379 - 395.e7 |0 PERI:(DE-600)2074034-7 |n 3 |p 379 - 395.e7 |t Cancer cell |v 34 |y 2018 |x 1535-6108 |
| 909 | C | O | |p VDB |o oai:inrepo02.dkfz.de:137641 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 4 |6 P:(DE-He78)b0b3740107f746e09dc23fdf25eb0629 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 5 |6 P:(DE-He78)2d0b899984e41ffa8cb15d799d32afd1 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 23 |6 P:(DE-He78)a4101d4d75f0b7d1f24f67ccbe63164b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 26 |6 P:(DE-He78)59ffe2957ee9f9009e7d4ec650023f47 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 27 |6 P:(DE-He78)a05fe89e8d9ccc1fbd56df77464c7856 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 28 |6 P:(DE-He78)0b115428d6170ebe021af308ed2a0cf1 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 29 |6 P:(DE-He78)082dd3179733e3e716a58eb90f418a78 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 31 |6 P:(DE-He78)36e1ec4777d5b7887344177dca41eae9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 32 |6 P:(DE-He78)26c413e17f63cb683978f4025fcb831e |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 36 |6 P:(DE-He78)8d9c904a6cea14d4c99c78ba46e41f93 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 41 |6 P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 42 |6 P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9 |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 43 |6 P:(DE-He78)0ac2bd1a9fb1823a351ee4434d80808b |
| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 45 |6 P:(DE-He78)a244aa021112b9002419791434bbc71c |
| 913 | 1 | _ | |a DE-HGF |l Krebsforschung |1 G:(DE-HGF)POF3-310 |0 G:(DE-HGF)POF3-319H |2 G:(DE-HGF)POF3-300 |v Addenda |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |b Gesundheit |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b CANCER CELL : 2015 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0310 |2 StatID |b NCBI Molecular Biology Database |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Thomson Reuters Master Journal List |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0110 |2 StatID |b Science Citation Index |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0111 |2 StatID |b Science Citation Index Expanded |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1030 |2 StatID |b Current Contents - Life Sciences |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |
| 915 | _ | _ | |a IF >= 20 |0 StatID:(DE-HGF)9920 |2 StatID |b CANCER CELL : 2015 |
| 920 | 1 | _ | |0 I:(DE-He78)B062-20160331 |k B062 |l Pädiatrische Neuroonkologie |x 0 |
| 920 | 1 | _ | |0 I:(DE-He78)L401-20160331 |k L401 |l DKTK Essen |x 1 |
| 920 | 1 | _ | |0 I:(DE-He78)G380-20160331 |k G380 |l KKE Neuropathologie |x 2 |
| 920 | 1 | _ | |0 I:(DE-He78)L101-20160331 |k L101 |l DKTK Heidelberg |x 3 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-He78)B062-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L401-20160331 |
| 980 | _ | _ | |a I:(DE-He78)G380-20160331 |
| 980 | _ | _ | |a I:(DE-He78)L101-20160331 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|