TY  - JOUR
AU  - Quinzler, R.
AU  - Freitag, M. H.
AU  - Wiese, B.
AU  - Beyer, M.
AU  - Brenner, H.
AU  - Dahlhaus, A.
AU  - Döring, A.
AU  - Freund, T.
AU  - Heier, M.
AU  - Knopf, H.
AU  - Luppa, M.
AU  - Prokein, J.
AU  - Riedel-Heller, S.
AU  - Schäfer, I.
AU  - Scheidt-Nave, C.
AU  - Scherer, M.
AU  - Schöttker, B.
AU  - Szecsenyi, J.
AU  - Thürmann, P.
AU  - van den Bussche, H.
AU  - Gensichen, J.
AU  - Haefeli, W. E.
TI  - A novel superior medication-based chronic disease score (medCDS) predicted all-cause mortality in independent geriatric cohorts.
JO  - Journal of clinical epidemiology
VL  - 105
SN  - 0895-4356
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-01564
SP  - 112-124
PY  - 2019
AB  - On the basis of current treatment guidelines, we developed and validated a medication-based chronic disease score (medCDS) and tested its association with all-cause mortality of older outpatients.Considering the most prevalent chronic diseases in the elderly German population, we compiled a list of evidence-based medicines used to treat these disorders. Based on this list, a score (medCDS) was developed to predict mortality using data of a large longitudinal cohort of older outpatients (training sample; MultiCare Cohort Study). By assessing receiver-operating characteristics (ROC curves), the performance of medCDS was then confirmed in independent cohorts (ESTHER, KORA-Age) of community-dwelling older patients and compared with already existing medication-based scores and a score using selected anatomical-therapeutic-chemical (ATC) codes.The final medCDS score had a ROC area-under-the-curve (AUC) of 0.73 (95 
LB  - PUB:(DE-HGF)16
C6  - pmid:30253216
DO  - DOI:10.1016/j.jclinepi.2018.09.004
UR  - https://inrepo02.dkfz.de/record/137687
ER  -