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@ARTICLE{Quinzler:137687,
      author       = {R. Quinzler and M. H. Freitag and B. Wiese and M. Beyer and
                      H. Brenner$^*$ and A. Dahlhaus and A. Döring and T. Freund
                      and M. Heier and H. Knopf and M. Luppa and J. Prokein and S.
                      Riedel-Heller and I. Schäfer and C. Scheidt-Nave and M.
                      Scherer and B. Schöttker$^*$ and J. Szecsenyi and P.
                      Thürmann and H. van den Bussche and J. Gensichen and W. E.
                      Haefeli},
      title        = {{A} novel superior medication-based chronic disease score
                      (med{CDS}) predicted all-cause mortality in independent
                      geriatric cohorts.},
      journal      = {Journal of clinical epidemiology},
      volume       = {105},
      issn         = {0895-4356},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DKFZ-2018-01564},
      pages        = {112-124},
      year         = {2019},
      abstract     = {On the basis of current treatment guidelines, we developed
                      and validated a medication-based chronic disease score
                      (medCDS) and tested its association with all-cause mortality
                      of older outpatients.Considering the most prevalent chronic
                      diseases in the elderly German population, we compiled a
                      list of evidence-based medicines used to treat these
                      disorders. Based on this list, a score (medCDS) was
                      developed to predict mortality using data of a large
                      longitudinal cohort of older outpatients (training sample;
                      MultiCare Cohort Study). By assessing receiver-operating
                      characteristics (ROC curves), the performance of medCDS was
                      then confirmed in independent cohorts (ESTHER, KORA-Age) of
                      community-dwelling older patients and compared with already
                      existing medication-based scores and a score using selected
                      anatomical-therapeutic-chemical (ATC) codes.The final medCDS
                      score had a ROC area-under-the-curve (AUC) of 0.73 (95
                      $\%-CI$ 0.70-0.76). In the validation cohorts, its ROC AUCs
                      were 0.79 (0.76-0.82, KORA-Age) and 0.74 (0.71-0.78,
                      ESTHER), which was superior to already existing
                      medication-based scores (RxRisk, CDS) and scores based on
                      pharmacological ATC code subgroups (ATC3) or age and sex
                      alone $(Age\&Sex).A$ new medication-based chronic disease
                      score (medCDS), which is based on actual treatment
                      standards, predicts mortality of older outpatients
                      significantly better than already existing scores.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30253216},
      doi          = {10.1016/j.jclinepi.2018.09.004},
      url          = {https://inrepo02.dkfz.de/record/137687},
}