%0 Journal Article
%A Yu, Haixin
%A Guan, Zhong
%A Cuk, Katarina
%A Brenner, Hermann
%A Zhang, Yan
%T Circulating microRNA biomarkers for lung cancer detection in Western populations.
%J Cancer medicine
%V 7
%N 10
%@ 2045-7634
%C Hoboken, NJ
%I Wiley
%M DKFZ-2018-01569
%P 4849-4862
%D 2018
%X Lung cancer (LC) is a leading cause of cancer-related death in the Western world. Patients with LC usually have poor prognosis due to the difficulties in detecting tumors at early stages. Multiple studies have shown that circulating miRNAs might be promising biomarkers for early detection of LC. We aimed to provide an overview of published studies on circulating miRNA markers for early detection of LC and to summarize their diagnostic performance in Western populations. A systematic literature search was performed in PubMed and ISI Web of Knowledge to find relevant studies published up to 11 August 2017. Information on study design, population characteristics, miRNA markers, and diagnostic accuracy (including sensitivity, specificity, and AUC) were independently extracted by two reviewers. Overall, 17 studies evaluating 35 circulating miRNA markers and 19 miRNA panels in serum or plasma were included. The median sensitivity (range) and specificity (range) were, respectively, 78.4
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30259714
%R 10.1002/cam4.1782
%U https://inrepo02.dkfz.de/record/137692