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@ARTICLE{Yu:137692,
      author       = {H. Yu$^*$ and Z. Guan$^*$ and K. Cuk$^*$ and H. Brenner$^*$
                      and Y. Zhang$^*$},
      title        = {{C}irculating micro{RNA} biomarkers for lung cancer
                      detection in {W}estern populations.},
      journal      = {Cancer medicine},
      volume       = {7},
      number       = {10},
      issn         = {2045-7634},
      address      = {Hoboken, NJ},
      publisher    = {Wiley},
      reportid     = {DKFZ-2018-01569},
      pages        = {4849-4862},
      year         = {2018},
      abstract     = {Lung cancer (LC) is a leading cause of cancer-related death
                      in the Western world. Patients with LC usually have poor
                      prognosis due to the difficulties in detecting tumors at
                      early stages. Multiple studies have shown that circulating
                      miRNAs might be promising biomarkers for early detection of
                      LC. We aimed to provide an overview of published studies on
                      circulating miRNA markers for early detection of LC and to
                      summarize their diagnostic performance in Western
                      populations. A systematic literature search was performed in
                      PubMed and ISI Web of Knowledge to find relevant studies
                      published up to 11 August 2017. Information on study design,
                      population characteristics, miRNA markers, and diagnostic
                      accuracy (including sensitivity, specificity, and AUC) were
                      independently extracted by two reviewers. Overall, 17
                      studies evaluating 35 circulating miRNA markers and 19 miRNA
                      panels in serum or plasma were included. The median
                      sensitivity (range) and specificity (range) were,
                      respectively, $78.4\%$ $(51.7\%-100\%)$ and $78.7\%$
                      $(42.9\%-93.5\%)$ for individual miRNAs, and $83.0\%$
                      $(64.0\%-100\%)$ and $84.9\%$ $(71.0\%-100\%)$ for miRNA
                      panels. Most studies incorporated individual miRNA markers
                      as panels (with 2-34 markers), with multiple miRNA-based
                      panels generally outperforming individual markers. Two
                      promising miRNA panels were discovered and verified in
                      prospective cohorts. Of note, both studies exclusively
                      applied miRNA ratios when building up panels. In conclusion,
                      circulating miRNAs may bear potential for noninvasive LC
                      screening, but large studies conducted in screening or
                      longitudinal settings are needed to validate the promising
                      results and optimize the marker panels.},
      subtyp        = {Review Article},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30259714},
      doi          = {10.1002/cam4.1782},
      url          = {https://inrepo02.dkfz.de/record/137692},
}