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@ARTICLE{Collaborators:140802,
author = {M. G. Griswold and N. Fullman and C. Hawley and N. Arian
and S. R. M. Zimsen and H. D. Tymeson and V. Venkateswaran
and A. D. Tapp and M. H. Forouzanfar and J. S. Salama and K.
H. Abate and D. Abate and S. M. Abay and C. Abbafati and R.
S. Abdulkader and Z. Abebe and V. Aboyans and M. M. Abrar
and P. Acharya and O. O. Adetokunboh and T. B. Adhikari and
J. C. Adsuar and M. Afarideh and E. E. Agardh and G. Agarwal
and S. A. Aghayan and S. Agrawal and M. B. Ahmed and M.
Akibu and T. Akinyemiju and N. Akseer and D. H. A. Asfoor
and Z. Al-Aly and F. Alahdab and K. Alam and A. Albujeer and
K. A. Alene and R. Ali and S. D. Ali and M. Alijanzadeh and
S. M. Aljunid and A. Alkerwi and P. Allebeck and N.
Alvis-Guzman and A. T. Amare and L. N. Aminde and W. Ammar
and Y. A. Amoako and G. G. H. Amul and C. L. Andrei and C.
Angus and M. G. Ansha and C. A. T. Antonio and O. Aremu and
J. Ärnlöv and A. Artaman and K. K. Aryal and R. Assadi and
M. Ausloos and L. Avila-Burgos and E. F. Avokpaho and A.
Awasthi and H. T. Ayele and R. Ayer and T. B. Ayuk and P. S.
Azzopardi and H. Badali and A. Badawi and M. Banach and S.
L. Barker-Collo and L. H. Barrero and H. Basaleem and E.
Baye and S. Bazargan-Hejazi and N. Bedi and Y. Béjot and A.
B. Belachew and S. A. Belay and D. A. Bennett and I. M.
Bensenor and E. Bernabe and R. S. Bernstein and A. S. Beyene
and T. Beyranvand and S. Bhaumik and Z. A. Bhutta and B.
Biadgo and A. Bijani and N. Bililign and S. M. Birlik and C.
Birungi and H. Bizuneh and P. Bjerregaard and T. Bjørge and
G. Borges and C. Bosetti and S. Boufous and N. L. Bragazzi
and H. Brenner$^*$ and Z. A. Butt and L. Cahuana-Hurtado and
B. Calabria and I. R. Campos-Nonato and J. C. Campuzano and
G. Carreras and J. J. Carrero and F. Carvalho and C. A.
Castañeda-Orjuela and J. Castillo Rivas and F.
Catalá-López and J.-C. Chang and F. J. Charlson and A.
Chattopadhyay and P. Chaturvedi and R. Chowdhury and D. J.
Christopher and S.-C. Chung and L. G. Ciobanu and R. M.
Claro and S. Conti and E. Cousin and M. H. Criqui and B. A.
Dachew and P. I. Dargan and A. Daryani and J. Das Neves and
K. Davletov and F. De Castro and B. De Courten and J.-W. De
Neve and L. Degenhardt and G. T. Demoz and D. C. Des Jarlais
and S. Dey and R. S. Dhaliwal and S. D. Dharmaratne and M.
Dhimal and D. T. Doku and K. E. Doyle and M. Dubey and E.
Dubljanin and B. B. Duncan and H. Ebrahimi and D. Edessa and
M. El Sayed Zaki and S. P. Ermakov and H. E. Erskine and A.
Esteghamati and M. Faramarzi and A. Farioli and A. Faro and
M. S. Farvid and F. Farzadfar and V. L. Feigin and M. S.
Felisbino-Mendes and E. Fernandes and A. J. Ferrari and C.
P. Ferri and D. O. Fijabi and I. Filip and J. D. Finger and
F. Fischer and A. D. Flaxman and R. C. Franklin and N. D.
Futran and S. Gallus and M. Ganji and F. G. Gankpe and G. B.
Gebregergs and T. T. Gebrehiwot and J. M. Geleijnse and R.
Ghadimi and L. A. Ghandour and M. Ghimire and P. S. Gill and
I. A. Ginawi and A. Z. Z. Giref and P. N. Gona and S. V.
Gopalani and C. C. Gotay and A. C. Goulart and F. Greaves
and G. Grosso and Y. Guo and R. Gupta and R. Gupta and V.
Gupta and R. A. Gutiérrez and M. Gvs and N. Hafezi-Nejad
and T. B. Hagos and G. B. Hailu and R. R. Hamadeh and S.
Hamidi and G. J. Hankey and H. L. Harb and S. Harikrishnan
and J. M. Haro and H. Y. Hassen and R. Havmoeller and S. I.
Hay and B. Heibati and A. Henok and I. Heredia-Pi and N. F.
Hernández-Llanes and C. Herteliu and D. T. T. Hibstu and P.
Hoogar and N. Horita and H. D. Hosgood and M. Hosseini and
M. Hostiuc and G. Hu and H. Huang and A. Husseini and B.
Idrisov and B. V. Ileanu and O. S. Ilesanmi and S. S. N.
Irvani and S. M. S. Islam and M. D. Jackson and M.
Jakovljevic and M. T. Jalu and A. U. Jayatilleke and R. P.
Jha and J. B. Jonas and J. J. Jozwiak and Z. Kabir and R.
Kadel and A. Kahsay and U. Kapil and A. Kasaeian and T. D.
D. Kassa and S. V. Katikireddi and N. Kawakami and S. Kebede
and A. T. Kefale and P. N. Keiyoro and A. P. Kengne and Y.
Khader and M. A. Khafaie and I. A. Khalil and M. N. Khan and
Y.-H. Khang and M. M. Khater and J. Khubchandani and C.-I.
Kim and D. Kim and Y. J. Kim and R. W. Kimokoti and A. Kisa
and M. Kivimäki and S. Kochhar and S. Kosen and P. A. Koul
and A. Koyanagi and K. Krishan and B. Kuate Defo and B.
Kucuk Bicer and V. S. Kulkarni and P. Kumar and A.
Lafranconi and A. Lakshmana Balaji and R. Lalloo and T.
Lallukka and H. Lam and F. H. Lami and Q. Lan and J. J. Lang
and S. Lansky and A. O. Larsson and A. Latifi and J. L.
Leasher and P. H. Lee and J. Leigh and M. Leinsalu and J.
Leung and M. Levi and Y. Li and L.-L. Lim and S. Linn and S.
Liu and A. Lobato-Cordero and A. D. Lopez and P. A. Lotufo
and E. R. K. Macarayan and I. E. Machado and F. Madotto and
H. Magdy Abd El Razek and M. Magdy Abd El Razek and M.
Majdan and R. Majdzadeh and A. Majeed and R. Malekzadeh and
D. C. Malta and C. C. Mapoma and J. Martinez-Raga and P. K.
Maulik and M. Mazidi and M. Mckee and V. Mehta and T. Meier
and T. Mekonen and K. G. Meles and A. Melese and P. T. N.
Memiah and W. Mendoza and D. T. Mengistu and G. A. Mensah
and T. J. Meretoja and H. B. Mezgebe and T. Miazgowski and
T. R. Miller and G. Mini and A. Mirica and E. M. Mirrakhimov
and B. Moazen and K. A. Mohammad and N. Mohammadifard and S.
Mohammed and L. Monasta and P. Moraga and L. Morawska and S.
M. Mousavi and S. Mukhopadhyay and K. I. Musa and A. Naheed
and G. Naik and F. Najafi and V. Nangia and J. R. Nansseu
and M. S. D. P. Nayak and C. Nejjari and S. Neupane and S.
P. Neupane and J. W. Ngunjiri and C. T. Nguyen and L. H.
Nguyen and T. H. Nguyen and D. N. A. Ningrum and Y. L.
Nirayo and J. J. Noubiap and R. Ofori-Asenso and F. A. Ogbo
and I.-H. Oh and O. Oladimeji and A. T. Olagunju and P. R.
Olivares and B. O. Olusanya and J. O. Olusanya and A. M.
Oommen and E. Oren and H. M. Orpana and D. D. V.
Ortega-Altamirano and J. R. Ortiz and E. Ota and M. O.
Owolabi and A. S. Oyekale and M. P A and A. Pana and E.-K.
Park and C. D. H. Parry and H. Parsian and A. Patle and G.
C. Patton and D. Paudel and M. Petzold and M. R. Phillips
and J. D. Pillay and M. J. Postma and F. Pourmalek and D.
Prabhakaran and M. Qorbani and A. Radfar and A. Rafay and A.
Rafiei and F. Rahim and A. Rahimi-Movaghar and M. Rahman and
M. A. Rahman and R. K. Rai and S. Rajsic and S. B. Raju and
U. Ram and S. M. Rana and C. L. Ranabhat and D. L. Rawaf and
S. Rawaf and R. C. Reiner and C. Reis and A. M. N. Renzaho
and M. S. Rezai and L. Roever and L. Ronfani and R. Room and
G. Roshandel and A. Rostami and G. A. Roth and A. Roy and Y.
D. Sabde and B. Saddik and S. Safiri and A. Sahebkar and J.
S. Salama and Z. Saleem and J. A. Salomon and S. S. Salvi
and J. Sanabria and M. D. Sanchez-Niño and D. F. Santomauro
and I. S. Santos and M. M. M. Santric Milicevic and A. R.
Sarker and R. Sarmiento-Suárez and N. Sarrafzadegan and B.
Sartorius and M. Satpathy and M. Sawhney and S. Saxena and
M. Saylan and M. P. Schaub and M. I. Schmidt and I. J. C.
Schneider and B. Schöttker$^*$ and A. E. Schutte and F.
Schwendicke and S. G. Sepanlou and M. A. Shaikh and M.
Sharif and J. She and A. Sheikh and J. Shen and M. S.
Shiferaw and M. Shigematsu and R. Shiri and K. Shishani and
I. Shiue and S. R. Shukla and I. D. Sigfusdottir and D. A.
S. Silva and N. T. D. Silva and D. G. A. Silveira and D. N.
Sinha and F. Sitas and A. M. Soares Filho and M. Soofi and
R. J. D. Sorensen and J. B. Soriano and C. T. Sreeramareddy
and N. Steckling and D. J. Stein and M. B. Sufiyan and P. J.
Sur and B. L. Sykes and R. Tabarés-Seisdedos and T. Tabuchi
and M. Tavakkoli and A. Tehrani-Banihashemi and M. G. Tekle
and S. Thapa and N. Thomas and R. Topor-Madry and F.
Topouzis and B. X. Tran and C. E. Troeger and T. C. Truelsen
and N. Tsilimparis and S. Tyrovolas and K. N. Ukwaja and I.
Ullah and O. A. Uthman and P. R. Valdez and J. F. M. Van
Boven and T. J. Vasankari and N. Venketasubramanian and F.
S. Violante and S. K. Vladimirov and V. Vlassov and S. E.
Vollset and T. Vos and F. W. S. Wagnew and Y. Waheed and
Y.-P. Wang and E. Weiderpass and F. Weldegebreal and K. G.
Weldegwergs and A. Werdecker and R. Westerman and H. A.
Whiteford and J. Widecka and T. Wijeratne and G. M. A. Wyper
and G. Xu and T. Yamada and Y. Yano and P. Ye and E. M.
Yimer and P. Yip and B. D. Yirsaw and E. Yisma and N.
Yonemoto and S.-J. Yoon and M. Yotebieng and M. Z. Younis
and G. Zachariah and Z. Zaidi and M. Zamani and X. Zhang and
S. Zodpey and A. H. Mokdad and M. Naghavi and C. J. L.
Murray and E. Gakidou},
collaboration = {GBD 2016 {Alcohol Collaborators}},
title = {{A}lcohol use and burden for 195 countries and territories,
1990-2016: a systematic analysis for the {G}lobal {B}urden
of {D}isease {S}tudy 2016.},
journal = {The lancet},
volume = {392},
number = {10152},
issn = {0140-6736},
address = {London [u.a.]},
publisher = {Elsevier},
reportid = {DKFZ-2018-01573},
pages = {1015 - 1035},
year = {2018},
abstract = {Alcohol use is a leading risk factor for death and
disability, but its overall association with health remains
complex given the possible protective effects of moderate
alcohol consumption on some conditions. With our
comprehensive approach to health accounting within the
Global Burden of Diseases, Injuries, and Risk Factors Study
2016, we generated improved estimates of alcohol use and
alcohol-attributable deaths and disability-adjusted
life-years (DALYs) for 195 locations from 1990 to 2016, for
both sexes and for 5-year age groups between the ages of 15
years and 95 years and older.Using 694 data sources of
individual and population-level alcohol consumption, along
with 592 prospective and retrospective studies on the risk
of alcohol use, we produced estimates of the prevalence of
current drinking, abstention, the distribution of alcohol
consumption among current drinkers in standard drinks daily
(defined as 10 g of pure ethyl alcohol), and
alcohol-attributable deaths and DALYs. We made several
methodological improvements compared with previous
estimates: first, we adjusted alcohol sales estimates to
take into account tourist and unrecorded consumption;
second, we did a new meta-analysis of relative risks for 23
health outcomes associated with alcohol use; and third, we
developed a new method to quantify the level of alcohol
consumption that minimises the overall risk to individual
health.Globally, alcohol use was the seventh leading risk
factor for both deaths and DALYs in 2016, accounting for
$2·2\%$ $(95\%$ uncertainty interval [UI] 1·5-3·0) of
age-standardised female deaths and $6·8\%$ (5·8-8·0) of
age-standardised male deaths. Among the population aged
15-49 years, alcohol use was the leading risk factor
globally in 2016, with $3·8\%$ $(95\%$ UI 3·2-4·3) of
female deaths and $12·2\%$ (10·8-13·6) of male deaths
attributable to alcohol use. For the population aged 15-49
years, female attributable DALYs were $2·3\%$ $(95\%$ UI
2·0-2·6) and male attributable DALYs were $8·9\%$
(7·8-9·9). The three leading causes of attributable deaths
in this age group were tuberculosis $(1·4\%$ $[95\%$ UI
1·0-1·7] of total deaths), road injuries $(1·2\%$
[0·7-1·9]), and self-harm $(1·1\%$ [0·6-1·5]). For
populations aged 50 years and older, cancers accounted for a
large proportion of total alcohol-attributable deaths in
2016, constituting $27·1\%$ $(95\%$ UI 21·2-33·3) of
total alcohol-attributable female deaths and $18·9\%$
(15·3-22·6) of male deaths. The level of alcohol
consumption that minimised harm across health outcomes was
zero $(95\%$ UI 0·0-0·8) standard drinks per week.Alcohol
use is a leading risk factor for global disease burden and
causes substantial health loss. We found that the risk of
all-cause mortality, and of cancers specifically, rises with
increasing levels of consumption, and the level of
consumption that minimises health loss is zero. These
results suggest that alcohol control policies might need to
be revised worldwide, refocusing on efforts to lower overall
population-level consumption.Bill $\&$ Melinda Gates
Foundation.},
cin = {C070 / G110},
ddc = {610},
cid = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30146330},
pmc = {pmc:PMC6148333},
doi = {10.1016/S0140-6736(18)31310-2},
url = {https://inrepo02.dkfz.de/record/140802},
}