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@ARTICLE{Collaborators:140802,
      author       = {M. G. Griswold and N. Fullman and C. Hawley and N. Arian
                      and S. R. M. Zimsen and H. D. Tymeson and V. Venkateswaran
                      and A. D. Tapp and M. H. Forouzanfar and J. S. Salama and K.
                      H. Abate and D. Abate and S. M. Abay and C. Abbafati and R.
                      S. Abdulkader and Z. Abebe and V. Aboyans and M. M. Abrar
                      and P. Acharya and O. O. Adetokunboh and T. B. Adhikari and
                      J. C. Adsuar and M. Afarideh and E. E. Agardh and G. Agarwal
                      and S. A. Aghayan and S. Agrawal and M. B. Ahmed and M.
                      Akibu and T. Akinyemiju and N. Akseer and D. H. A. Asfoor
                      and Z. Al-Aly and F. Alahdab and K. Alam and A. Albujeer and
                      K. A. Alene and R. Ali and S. D. Ali and M. Alijanzadeh and
                      S. M. Aljunid and A. Alkerwi and P. Allebeck and N.
                      Alvis-Guzman and A. T. Amare and L. N. Aminde and W. Ammar
                      and Y. A. Amoako and G. G. H. Amul and C. L. Andrei and C.
                      Angus and M. G. Ansha and C. A. T. Antonio and O. Aremu and
                      J. Ärnlöv and A. Artaman and K. K. Aryal and R. Assadi and
                      M. Ausloos and L. Avila-Burgos and E. F. Avokpaho and A.
                      Awasthi and H. T. Ayele and R. Ayer and T. B. Ayuk and P. S.
                      Azzopardi and H. Badali and A. Badawi and M. Banach and S.
                      L. Barker-Collo and L. H. Barrero and H. Basaleem and E.
                      Baye and S. Bazargan-Hejazi and N. Bedi and Y. Béjot and A.
                      B. Belachew and S. A. Belay and D. A. Bennett and I. M.
                      Bensenor and E. Bernabe and R. S. Bernstein and A. S. Beyene
                      and T. Beyranvand and S. Bhaumik and Z. A. Bhutta and B.
                      Biadgo and A. Bijani and N. Bililign and S. M. Birlik and C.
                      Birungi and H. Bizuneh and P. Bjerregaard and T. Bjørge and
                      G. Borges and C. Bosetti and S. Boufous and N. L. Bragazzi
                      and H. Brenner$^*$ and Z. A. Butt and L. Cahuana-Hurtado and
                      B. Calabria and I. R. Campos-Nonato and J. C. Campuzano and
                      G. Carreras and J. J. Carrero and F. Carvalho and C. A.
                      Castañeda-Orjuela and J. Castillo Rivas and F.
                      Catalá-López and J.-C. Chang and F. J. Charlson and A.
                      Chattopadhyay and P. Chaturvedi and R. Chowdhury and D. J.
                      Christopher and S.-C. Chung and L. G. Ciobanu and R. M.
                      Claro and S. Conti and E. Cousin and M. H. Criqui and B. A.
                      Dachew and P. I. Dargan and A. Daryani and J. Das Neves and
                      K. Davletov and F. De Castro and B. De Courten and J.-W. De
                      Neve and L. Degenhardt and G. T. Demoz and D. C. Des Jarlais
                      and S. Dey and R. S. Dhaliwal and S. D. Dharmaratne and M.
                      Dhimal and D. T. Doku and K. E. Doyle and M. Dubey and E.
                      Dubljanin and B. B. Duncan and H. Ebrahimi and D. Edessa and
                      M. El Sayed Zaki and S. P. Ermakov and H. E. Erskine and A.
                      Esteghamati and M. Faramarzi and A. Farioli and A. Faro and
                      M. S. Farvid and F. Farzadfar and V. L. Feigin and M. S.
                      Felisbino-Mendes and E. Fernandes and A. J. Ferrari and C.
                      P. Ferri and D. O. Fijabi and I. Filip and J. D. Finger and
                      F. Fischer and A. D. Flaxman and R. C. Franklin and N. D.
                      Futran and S. Gallus and M. Ganji and F. G. Gankpe and G. B.
                      Gebregergs and T. T. Gebrehiwot and J. M. Geleijnse and R.
                      Ghadimi and L. A. Ghandour and M. Ghimire and P. S. Gill and
                      I. A. Ginawi and A. Z. Z. Giref and P. N. Gona and S. V.
                      Gopalani and C. C. Gotay and A. C. Goulart and F. Greaves
                      and G. Grosso and Y. Guo and R. Gupta and R. Gupta and V.
                      Gupta and R. A. Gutiérrez and M. Gvs and N. Hafezi-Nejad
                      and T. B. Hagos and G. B. Hailu and R. R. Hamadeh and S.
                      Hamidi and G. J. Hankey and H. L. Harb and S. Harikrishnan
                      and J. M. Haro and H. Y. Hassen and R. Havmoeller and S. I.
                      Hay and B. Heibati and A. Henok and I. Heredia-Pi and N. F.
                      Hernández-Llanes and C. Herteliu and D. T. T. Hibstu and P.
                      Hoogar and N. Horita and H. D. Hosgood and M. Hosseini and
                      M. Hostiuc and G. Hu and H. Huang and A. Husseini and B.
                      Idrisov and B. V. Ileanu and O. S. Ilesanmi and S. S. N.
                      Irvani and S. M. S. Islam and M. D. Jackson and M.
                      Jakovljevic and M. T. Jalu and A. U. Jayatilleke and R. P.
                      Jha and J. B. Jonas and J. J. Jozwiak and Z. Kabir and R.
                      Kadel and A. Kahsay and U. Kapil and A. Kasaeian and T. D.
                      D. Kassa and S. V. Katikireddi and N. Kawakami and S. Kebede
                      and A. T. Kefale and P. N. Keiyoro and A. P. Kengne and Y.
                      Khader and M. A. Khafaie and I. A. Khalil and M. N. Khan and
                      Y.-H. Khang and M. M. Khater and J. Khubchandani and C.-I.
                      Kim and D. Kim and Y. J. Kim and R. W. Kimokoti and A. Kisa
                      and M. Kivimäki and S. Kochhar and S. Kosen and P. A. Koul
                      and A. Koyanagi and K. Krishan and B. Kuate Defo and B.
                      Kucuk Bicer and V. S. Kulkarni and P. Kumar and A.
                      Lafranconi and A. Lakshmana Balaji and R. Lalloo and T.
                      Lallukka and H. Lam and F. H. Lami and Q. Lan and J. J. Lang
                      and S. Lansky and A. O. Larsson and A. Latifi and J. L.
                      Leasher and P. H. Lee and J. Leigh and M. Leinsalu and J.
                      Leung and M. Levi and Y. Li and L.-L. Lim and S. Linn and S.
                      Liu and A. Lobato-Cordero and A. D. Lopez and P. A. Lotufo
                      and E. R. K. Macarayan and I. E. Machado and F. Madotto and
                      H. Magdy Abd El Razek and M. Magdy Abd El Razek and M.
                      Majdan and R. Majdzadeh and A. Majeed and R. Malekzadeh and
                      D. C. Malta and C. C. Mapoma and J. Martinez-Raga and P. K.
                      Maulik and M. Mazidi and M. Mckee and V. Mehta and T. Meier
                      and T. Mekonen and K. G. Meles and A. Melese and P. T. N.
                      Memiah and W. Mendoza and D. T. Mengistu and G. A. Mensah
                      and T. J. Meretoja and H. B. Mezgebe and T. Miazgowski and
                      T. R. Miller and G. Mini and A. Mirica and E. M. Mirrakhimov
                      and B. Moazen and K. A. Mohammad and N. Mohammadifard and S.
                      Mohammed and L. Monasta and P. Moraga and L. Morawska and S.
                      M. Mousavi and S. Mukhopadhyay and K. I. Musa and A. Naheed
                      and G. Naik and F. Najafi and V. Nangia and J. R. Nansseu
                      and M. S. D. P. Nayak and C. Nejjari and S. Neupane and S.
                      P. Neupane and J. W. Ngunjiri and C. T. Nguyen and L. H.
                      Nguyen and T. H. Nguyen and D. N. A. Ningrum and Y. L.
                      Nirayo and J. J. Noubiap and R. Ofori-Asenso and F. A. Ogbo
                      and I.-H. Oh and O. Oladimeji and A. T. Olagunju and P. R.
                      Olivares and B. O. Olusanya and J. O. Olusanya and A. M.
                      Oommen and E. Oren and H. M. Orpana and D. D. V.
                      Ortega-Altamirano and J. R. Ortiz and E. Ota and M. O.
                      Owolabi and A. S. Oyekale and M. P A and A. Pana and E.-K.
                      Park and C. D. H. Parry and H. Parsian and A. Patle and G.
                      C. Patton and D. Paudel and M. Petzold and M. R. Phillips
                      and J. D. Pillay and M. J. Postma and F. Pourmalek and D.
                      Prabhakaran and M. Qorbani and A. Radfar and A. Rafay and A.
                      Rafiei and F. Rahim and A. Rahimi-Movaghar and M. Rahman and
                      M. A. Rahman and R. K. Rai and S. Rajsic and S. B. Raju and
                      U. Ram and S. M. Rana and C. L. Ranabhat and D. L. Rawaf and
                      S. Rawaf and R. C. Reiner and C. Reis and A. M. N. Renzaho
                      and M. S. Rezai and L. Roever and L. Ronfani and R. Room and
                      G. Roshandel and A. Rostami and G. A. Roth and A. Roy and Y.
                      D. Sabde and B. Saddik and S. Safiri and A. Sahebkar and J.
                      S. Salama and Z. Saleem and J. A. Salomon and S. S. Salvi
                      and J. Sanabria and M. D. Sanchez-Niño and D. F. Santomauro
                      and I. S. Santos and M. M. M. Santric Milicevic and A. R.
                      Sarker and R. Sarmiento-Suárez and N. Sarrafzadegan and B.
                      Sartorius and M. Satpathy and M. Sawhney and S. Saxena and
                      M. Saylan and M. P. Schaub and M. I. Schmidt and I. J. C.
                      Schneider and B. Schöttker$^*$ and A. E. Schutte and F.
                      Schwendicke and S. G. Sepanlou and M. A. Shaikh and M.
                      Sharif and J. She and A. Sheikh and J. Shen and M. S.
                      Shiferaw and M. Shigematsu and R. Shiri and K. Shishani and
                      I. Shiue and S. R. Shukla and I. D. Sigfusdottir and D. A.
                      S. Silva and N. T. D. Silva and D. G. A. Silveira and D. N.
                      Sinha and F. Sitas and A. M. Soares Filho and M. Soofi and
                      R. J. D. Sorensen and J. B. Soriano and C. T. Sreeramareddy
                      and N. Steckling and D. J. Stein and M. B. Sufiyan and P. J.
                      Sur and B. L. Sykes and R. Tabarés-Seisdedos and T. Tabuchi
                      and M. Tavakkoli and A. Tehrani-Banihashemi and M. G. Tekle
                      and S. Thapa and N. Thomas and R. Topor-Madry and F.
                      Topouzis and B. X. Tran and C. E. Troeger and T. C. Truelsen
                      and N. Tsilimparis and S. Tyrovolas and K. N. Ukwaja and I.
                      Ullah and O. A. Uthman and P. R. Valdez and J. F. M. Van
                      Boven and T. J. Vasankari and N. Venketasubramanian and F.
                      S. Violante and S. K. Vladimirov and V. Vlassov and S. E.
                      Vollset and T. Vos and F. W. S. Wagnew and Y. Waheed and
                      Y.-P. Wang and E. Weiderpass and F. Weldegebreal and K. G.
                      Weldegwergs and A. Werdecker and R. Westerman and H. A.
                      Whiteford and J. Widecka and T. Wijeratne and G. M. A. Wyper
                      and G. Xu and T. Yamada and Y. Yano and P. Ye and E. M.
                      Yimer and P. Yip and B. D. Yirsaw and E. Yisma and N.
                      Yonemoto and S.-J. Yoon and M. Yotebieng and M. Z. Younis
                      and G. Zachariah and Z. Zaidi and M. Zamani and X. Zhang and
                      S. Zodpey and A. H. Mokdad and M. Naghavi and C. J. L.
                      Murray and E. Gakidou},
      collaboration = {GBD 2016 {Alcohol Collaborators}},
      title        = {{A}lcohol use and burden for 195 countries and territories,
                      1990-2016: a systematic analysis for the {G}lobal {B}urden
                      of {D}isease {S}tudy 2016.},
      journal      = {The lancet},
      volume       = {392},
      number       = {10152},
      issn         = {0140-6736},
      address      = {London [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2018-01573},
      pages        = {1015 - 1035},
      year         = {2018},
      abstract     = {Alcohol use is a leading risk factor for death and
                      disability, but its overall association with health remains
                      complex given the possible protective effects of moderate
                      alcohol consumption on some conditions. With our
                      comprehensive approach to health accounting within the
                      Global Burden of Diseases, Injuries, and Risk Factors Study
                      2016, we generated improved estimates of alcohol use and
                      alcohol-attributable deaths and disability-adjusted
                      life-years (DALYs) for 195 locations from 1990 to 2016, for
                      both sexes and for 5-year age groups between the ages of 15
                      years and 95 years and older.Using 694 data sources of
                      individual and population-level alcohol consumption, along
                      with 592 prospective and retrospective studies on the risk
                      of alcohol use, we produced estimates of the prevalence of
                      current drinking, abstention, the distribution of alcohol
                      consumption among current drinkers in standard drinks daily
                      (defined as 10 g of pure ethyl alcohol), and
                      alcohol-attributable deaths and DALYs. We made several
                      methodological improvements compared with previous
                      estimates: first, we adjusted alcohol sales estimates to
                      take into account tourist and unrecorded consumption;
                      second, we did a new meta-analysis of relative risks for 23
                      health outcomes associated with alcohol use; and third, we
                      developed a new method to quantify the level of alcohol
                      consumption that minimises the overall risk to individual
                      health.Globally, alcohol use was the seventh leading risk
                      factor for both deaths and DALYs in 2016, accounting for
                      $2·2\%$ $(95\%$ uncertainty interval [UI] 1·5-3·0) of
                      age-standardised female deaths and $6·8\%$ (5·8-8·0) of
                      age-standardised male deaths. Among the population aged
                      15-49 years, alcohol use was the leading risk factor
                      globally in 2016, with $3·8\%$ $(95\%$ UI 3·2-4·3) of
                      female deaths and $12·2\%$ (10·8-13·6) of male deaths
                      attributable to alcohol use. For the population aged 15-49
                      years, female attributable DALYs were $2·3\%$ $(95\%$ UI
                      2·0-2·6) and male attributable DALYs were $8·9\%$
                      (7·8-9·9). The three leading causes of attributable deaths
                      in this age group were tuberculosis $(1·4\%$ $[95\%$ UI
                      1·0-1·7] of total deaths), road injuries $(1·2\%$
                      [0·7-1·9]), and self-harm $(1·1\%$ [0·6-1·5]). For
                      populations aged 50 years and older, cancers accounted for a
                      large proportion of total alcohol-attributable deaths in
                      2016, constituting $27·1\%$ $(95\%$ UI 21·2-33·3) of
                      total alcohol-attributable female deaths and $18·9\%$
                      (15·3-22·6) of male deaths. The level of alcohol
                      consumption that minimised harm across health outcomes was
                      zero $(95\%$ UI 0·0-0·8) standard drinks per week.Alcohol
                      use is a leading risk factor for global disease burden and
                      causes substantial health loss. We found that the risk of
                      all-cause mortality, and of cancers specifically, rises with
                      increasing levels of consumption, and the level of
                      consumption that minimises health loss is zero. These
                      results suggest that alcohol control policies might need to
                      be revised worldwide, refocusing on efforts to lower overall
                      population-level consumption.Bill $\&$ Melinda Gates
                      Foundation.},
      cin          = {C070 / G110},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30146330},
      pmc          = {pmc:PMC6148333},
      doi          = {10.1016/S0140-6736(18)31310-2},
      url          = {https://inrepo02.dkfz.de/record/140802},
}