TY  - JOUR
AU  - Braess, Jan
AU  - Amler, Susanne
AU  - Kreuzer, Karl-Anton
AU  - Spiekermann, Karsten
AU  - Lindemann, Hans Walter
AU  - Lengfelder, Eva
AU  - Graeven, Ullrich
AU  - Staib, Peter
AU  - Ludwig, Wolf-Dieter
AU  - Biersack, Harald
AU  - Ko, Yon-Dschun
AU  - Uppenkamp, Michael J
AU  - De Wit, Maike
AU  - Korsten, Stefan
AU  - Peceny, Rudolf
AU  - Gaska, Tobias
AU  - Schiel, Xaver
AU  - Behringer, Dirk M
AU  - Kiehl, Michael G
AU  - Zinngrebe, Bettina
AU  - Meckenstock, Gerald
AU  - Roemer, Eva
AU  - Medgenberg, Dirk
AU  - Spaeth-Schwalbe, Ernst
AU  - Massenkeil, Gero
AU  - Hindahl, Heidrun
AU  - Schwerdtfeger, Rainer
AU  - Trenn, Guido
AU  - Sauerland, Cristina
AU  - Koch, Raphael
AU  - Lablans, Martin
AU  - Faldum, Andreas
AU  - Görlich, Dennis
AU  - Bohlander, Stefan K
AU  - Schneider, Stephanie
AU  - Dufour, Annika
AU  - Buske, Christian
AU  - Fiegl, Michael
AU  - Subklewe, Marion
AU  - Braess, Birgit
AU  - Unterhalt, Michael
AU  - Baumgartner, Anja
AU  - Wörmann, Bernhard
AU  - Beelen, Dietrich
AU  - Hiddemann, Wolfgang
TI  - Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study.
JO  - Leukemia
VL  - 32
IS  - 12
SN  - 1476-5551
CY  - London
PB  - Springer Nature
M1  - DKFZ-2018-01610
SP  - 2558-2572
PY  - 2018
AB  - Dose-dense induction with the S-HAM regimen was compared to standard double induction therapy in adult patients with newly diagnosed acute myeloid leukemia. Patients were centrally randomized (1:1) between S-HAM (2nd chemotherapy cycle starting on day 8 = 'dose-dense') and double induction with TAD-HAM or HAM(-HAM) (2nd cycle starting on day 21 = 'standard'). 387 evaluable patients were randomly assigned to S-HAM (N = 203) and to standard double induction (N = 184). The primary endpoint overall response rate (ORR) consisting of complete remission (CR) and incomplete remission (CRi) was not significantly different (P = 0.202) between S-HAM (77
LB  - PUB:(DE-HGF)16
C6  - pmid:30275528
DO  - DOI:10.1038/s41375-018-0268-9
UR  - https://inrepo02.dkfz.de/record/140855
ER  -