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@ARTICLE{Braess:140855,
      author       = {J. Braess and S. Amler and K.-A. Kreuzer and K. Spiekermann
                      and H. W. Lindemann and E. Lengfelder and U. Graeven and P.
                      Staib and W.-D. Ludwig and H. Biersack and Y.-D. Ko and M.
                      J. Uppenkamp and M. De Wit and S. Korsten and R. Peceny and
                      T. Gaska and X. Schiel and D. M. Behringer and M. G. Kiehl
                      and B. Zinngrebe and G. Meckenstock and E. Roemer and D.
                      Medgenberg and E. Spaeth-Schwalbe and G. Massenkeil and H.
                      Hindahl and R. Schwerdtfeger and G. Trenn and C. Sauerland
                      and R. Koch and M. Lablans$^*$ and A. Faldum and D. Görlich
                      and S. K. Bohlander and S. Schneider and A. Dufour and C.
                      Buske and M. Fiegl and M. Subklewe and B. Braess and M.
                      Unterhalt and A. Baumgartner and B. Wörmann and D. Beelen
                      and W. Hiddemann},
      collaboration = {AML-CG},
      title        = {{S}equential high-dose cytarabine and mitoxantrone
                      ({S}-{HAM}) versus standard double induction in acute
                      myeloid leukemia-a phase 3 study.},
      journal      = {Leukemia},
      volume       = {32},
      number       = {12},
      issn         = {1476-5551},
      address      = {London},
      publisher    = {Springer Nature},
      reportid     = {DKFZ-2018-01610},
      pages        = {2558-2572},
      year         = {2018},
      abstract     = {Dose-dense induction with the S-HAM regimen was compared to
                      standard double induction therapy in adult patients with
                      newly diagnosed acute myeloid leukemia. Patients were
                      centrally randomized (1:1) between S-HAM (2nd chemotherapy
                      cycle starting on day 8 = 'dose-dense') and double
                      induction with TAD-HAM or HAM(-HAM) (2nd cycle starting on
                      day 21 = 'standard'). 387 evaluable patients were
                      randomly assigned to S-HAM (N = 203) and to standard
                      double induction (N = 184). The primary endpoint overall
                      response rate (ORR) consisting of complete remission (CR)
                      and incomplete remission (CRi) was not significantly
                      different (P = 0.202) between S-HAM $(77\%)$ and double
                      induction $(72\%).$ The median overall survival was 35
                      months after S-HAM and 25 months after double induction
                      (P = 0.323). Duration of critical leukopenia was
                      significantly reduced after S-HAM (median 29 days) versus
                      double induction (median 44 days)-P < 0.001. This
                      translated into a significantly shortened duration of
                      hospitalization after S-HAM (median 37 days) as compared to
                      standard induction (median 49 days)-P < 0.001. In
                      conclusion, dose-dense induction therapy with the S-HAM
                      regimen shows favorable trends but no significant
                      differences in ORR and OS compared to standard double
                      induction. S-HAM significantly shortens critical leukopenia
                      and the duration of hospitalization by 2 weeks.},
      cin          = {G230},
      ddc          = {610},
      cid          = {I:(DE-He78)G230-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30275528},
      doi          = {10.1038/s41375-018-0268-9},
      url          = {https://inrepo02.dkfz.de/record/140855},
}