000140861 001__ 140861
000140861 005__ 20240229105118.0
000140861 0247_ $$2doi$$a10.2147/CLEP.S170169
000140861 0247_ $$2pmid$$apmid:30271216
000140861 0247_ $$2pmc$$apmc:PMC6147538
000140861 0247_ $$2altmetric$$aaltmetric:48504777
000140861 037__ $$aDKFZ-2018-01616
000140861 041__ $$aeng
000140861 082__ $$a610
000140861 1001_ $$0P:(DE-He78)20dc4ad11ff465acf5b99f1e679e10b7$$aNiedermaier, Tobias$$b0$$eFirst author$$udkfz
000140861 245__ $$aAccuracy of a fecal immunochemical test according to outside temperature and travel time.
000140861 260__ $$aAlbany, Auckland$$bDove Medical Press$$c2018
000140861 3367_ $$2DRIVER$$aarticle
000140861 3367_ $$2DataCite$$aOutput Types/Journal article
000140861 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1660051496_23715
000140861 3367_ $$2BibTeX$$aARTICLE
000140861 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000140861 3367_ $$00$$2EndNote$$aJournal Article
000140861 520__ $$aFecal immunochemical tests (FITs) are widely used and recommended for colorectal cancer (CRC) screening. Fecal hemoglobin (Hb) may degrade with long transport durations and high ambient temperatures, potentially reducing sensitivity to detect CRC and its precursors. This study aimed at investigating the impact of temperatures and sample travel times on diagnostic performance of a quantitative FIT for detection of advanced neoplasms (AN, CRC, or advanced adenoma).Participants of screening colonoscopy in south-western Germany conducted a quantitative FIT prior to bowel preparation between February 2012 and June 2016. From available locations and dates of stool sampling and transport, maximum ambient temperatures were linked to 2,870 participants aged 50-79 years and sample return durations were recorded. The impact of ambient temperatures and return duration on FIT sensitivity and specificity was assessed for five different cutoffs between 10 and 25 µg Hb/g feces.At a positivity threshold of 20 µg Hb/g feces, overall sensitivity and specificity for detecting any AN were 40% (95% CI, 35-47%) and 95% (95% CI, 94-96%), respectively. Inverse associations between maximum ambient temperature (median 18.1°C, inter-quartile range [IQR] =11.4-24.9°C) and sensitivity of FIT were observed which were stronger at higher cutoffs. Sample return durations (median 6 days, IQR =4-8 days) were not associated with variable sensitivities or specificities.Hb degredation during fecal sample transportation in summer months may be of some concern for diagnostic performance of the FIT evaluated under routine conditions in a middle-European climate.
000140861 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000140861 588__ $$aDataset connected to CrossRef, PubMed,
000140861 7001_ $$0P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aWeigl, Korbinian$$b1$$udkfz
000140861 7001_ $$0P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aGies, Anton$$b2$$udkfz
000140861 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b3$$udkfz
000140861 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$eLast author$$udkfz
000140861 773__ $$0PERI:(DE-600)2494772-6$$a10.2147/CLEP.S170169$$gVol. 10, p. 1203 - 1213$$p1203 - 1213$$tClinical epidemiology$$v10$$x1179-1349$$y2018
000140861 909CO $$ooai:inrepo02.dkfz.de:140861$$pVDB
000140861 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)20dc4ad11ff465acf5b99f1e679e10b7$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000140861 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000140861 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6d4d6a0e2d726f899086ca98cd560922$$aDeutsches Krebsforschungszentrum$$b2$$kDKFZ
000140861 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b3$$kDKFZ
000140861 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000140861 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000140861 9141_ $$y2018
000140861 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCLIN EPIDEMIOL : 2017
000140861 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000140861 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000140861 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000140861 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000140861 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000140861 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review
000140861 915__ $$0LIC:(DE-HGF)CCBYNCNV$$2V:(DE-HGF)$$aCreative Commons Attribution-NonCommercial CC BY-NC (No Version)$$bDOAJ
000140861 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000140861 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000140861 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000140861 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000140861 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000140861 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000140861 9201_ $$0I:(DE-He78)G110-20160331$$kG110$$lPräventive Onkologie$$x1
000140861 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x2
000140861 980__ $$ajournal
000140861 980__ $$aVDB
000140861 980__ $$aI:(DE-He78)C070-20160331
000140861 980__ $$aI:(DE-He78)G110-20160331
000140861 980__ $$aI:(DE-He78)L101-20160331
000140861 980__ $$aUNRESTRICTED