TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Weigl, Korbinian
AU  - Gies, Anton
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Accuracy of a fecal immunochemical test according to outside temperature and travel time.
JO  - Clinical epidemiology
VL  - 10
SN  - 1179-1349
CY  - Albany, Auckland
PB  - Dove Medical Press
M1  - DKFZ-2018-01616
SP  - 1203 - 1213
PY  - 2018
AB  - Fecal immunochemical tests (FITs) are widely used and recommended for colorectal cancer (CRC) screening. Fecal hemoglobin (Hb) may degrade with long transport durations and high ambient temperatures, potentially reducing sensitivity to detect CRC and its precursors. This study aimed at investigating the impact of temperatures and sample travel times on diagnostic performance of a quantitative FIT for detection of advanced neoplasms (AN, CRC, or advanced adenoma).Participants of screening colonoscopy in south-western Germany conducted a quantitative FIT prior to bowel preparation between February 2012 and June 2016. From available locations and dates of stool sampling and transport, maximum ambient temperatures were linked to 2,870 participants aged 50-79 years and sample return durations were recorded. The impact of ambient temperatures and return duration on FIT sensitivity and specificity was assessed for five different cutoffs between 10 and 25 µg Hb/g feces.At a positivity threshold of 20 µg Hb/g feces, overall sensitivity and specificity for detecting any AN were 40
LB  - PUB:(DE-HGF)16
C6  - pmid:30271216
C2  - pmc:PMC6147538
DO  - DOI:10.2147/CLEP.S170169
UR  - https://inrepo02.dkfz.de/record/140861
ER  -