% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Niedermaier:140861,
      author       = {T. Niedermaier$^*$ and K. Weigl$^*$ and A. Gies$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{A}ccuracy of a fecal immunochemical test according to
                      outside temperature and travel time.},
      journal      = {Clinical epidemiology},
      volume       = {10},
      issn         = {1179-1349},
      address      = {Albany, Auckland},
      publisher    = {Dove Medical Press},
      reportid     = {DKFZ-2018-01616},
      pages        = {1203 - 1213},
      year         = {2018},
      abstract     = {Fecal immunochemical tests (FITs) are widely used and
                      recommended for colorectal cancer (CRC) screening. Fecal
                      hemoglobin (Hb) may degrade with long transport durations
                      and high ambient temperatures, potentially reducing
                      sensitivity to detect CRC and its precursors. This study
                      aimed at investigating the impact of temperatures and sample
                      travel times on diagnostic performance of a quantitative FIT
                      for detection of advanced neoplasms (AN, CRC, or advanced
                      adenoma).Participants of screening colonoscopy in
                      south-western Germany conducted a quantitative FIT prior to
                      bowel preparation between February 2012 and June 2016. From
                      available locations and dates of stool sampling and
                      transport, maximum ambient temperatures were linked to 2,870
                      participants aged 50-79 years and sample return durations
                      were recorded. The impact of ambient temperatures and return
                      duration on FIT sensitivity and specificity was assessed for
                      five different cutoffs between 10 and 25 µg Hb/g feces.At a
                      positivity threshold of 20 µg Hb/g feces, overall
                      sensitivity and specificity for detecting any AN were $40\%$
                      $(95\%$ CI, $35-47\%)$ and $95\%$ $(95\%$ CI, $94-96\%),$
                      respectively. Inverse associations between maximum ambient
                      temperature (median 18.1°C, inter-quartile range [IQR]
                      =11.4-24.9°C) and sensitivity of FIT were observed which
                      were stronger at higher cutoffs. Sample return durations
                      (median 6 days, IQR =4-8 days) were not associated with
                      variable sensitivities or specificities.Hb degredation
                      during fecal sample transportation in summer months may be
                      of some concern for diagnostic performance of the FIT
                      evaluated under routine conditions in a middle-European
                      climate.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30271216},
      pmc          = {pmc:PMC6147538},
      doi          = {10.2147/CLEP.S170169},
      url          = {https://inrepo02.dkfz.de/record/140861},
}