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000141114 0247_ $$2doi$$a10.1038/s41467-018-06541-2
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000141114 1001_ $$aMcMaster, Mary L$$b0
000141114 245__ $$aTwo high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia.
000141114 260__ $$a[London]$$bNature Publishing Group UK$$c2018
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000141114 520__ $$aWaldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P = 1.36 × 10-54) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45-6.96, P = 8.75 × 10-19). Both risk alleles are observed at a low frequency among controls (~2-3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy.
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000141114 7001_ $$aBerndt, Sonja I$$b1
000141114 7001_ $$00000-0001-5246-3371$$aZhang, Jianqing$$b2
000141114 7001_ $$aSlager, Susan L$$b3
000141114 7001_ $$aLi, Shengchao Alfred$$b4
000141114 7001_ $$00000-0002-3612-8298$$aVajdic, Claire M$$b5
000141114 7001_ $$aSmedby, Karin E$$b6
000141114 7001_ $$00000-0003-0756-2922$$aYan, Huihuang$$b7
000141114 7001_ $$aBirmann, Brenda M$$b8
000141114 7001_ $$aBrown, Elizabeth E$$b9
000141114 7001_ $$aSmith, Alex$$b10
000141114 7001_ $$aKleinstern, Geffen$$b11
000141114 7001_ $$aFansler, Mervin M$$b12
000141114 7001_ $$00000-0002-7084-7608$$aMayr, Christine$$b13
000141114 7001_ $$aZhu, Bin$$b14
000141114 7001_ $$aChung, Charles C$$b15
000141114 7001_ $$aPark, Ju-Hyun$$b16
000141114 7001_ $$aBurdette, Laurie$$b17
000141114 7001_ $$aHicks, Belynda D$$b18
000141114 7001_ $$aHutchinson, Amy$$b19
000141114 7001_ $$aTeras, Lauren R$$b20
000141114 7001_ $$aAdami, Hans-Olov$$b21
000141114 7001_ $$aBracci, Paige M$$b22
000141114 7001_ $$aMcKay, James$$b23
000141114 7001_ $$aMonnereau, Alain$$b24
000141114 7001_ $$aLink, Brian K$$b25
000141114 7001_ $$aVermeulen, Roel C H$$b26
000141114 7001_ $$aAnsell, Stephen M$$b27
000141114 7001_ $$aMaria, Ann$$b28
000141114 7001_ $$00000-0002-5418-9000$$aDiver, W Ryan$$b29
000141114 7001_ $$aMelbye, Mads$$b30
000141114 7001_ $$aOjesina, Akinyemi I$$b31
000141114 7001_ $$aKraft, Peter$$b32
000141114 7001_ $$aBoffetta, Paolo$$b33
000141114 7001_ $$aClavel, Jacqueline$$b34
000141114 7001_ $$aGiovannucci, Edward$$b35
000141114 7001_ $$aBesson, Caroline M$$b36
000141114 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b37$$udkfz
000141114 7001_ $$aTravis, Ruth C$$b38
000141114 7001_ $$aVineis, Paolo$$b39
000141114 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b40
000141114 7001_ $$aMontalvan, Rebecca$$b41
000141114 7001_ $$aWang, Zhaoming$$b42
000141114 7001_ $$aYeager, Meredith$$b43
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000141114 7001_ $$00000-0002-0518-8714$$aBrennan, Paul$$b46
000141114 7001_ $$aForetova, Lenka$$b47
000141114 7001_ $$aMaynadie, Marc$$b48
000141114 7001_ $$aNieters, Alexandra$$b49
000141114 7001_ $$ade Sanjose, Silvia$$b50
000141114 7001_ $$00000-0001-9161-1357$$aStaines, Anthony$$b51
000141114 7001_ $$aConde, Lucia$$b52
000141114 7001_ $$aRiby, Jacques$$b53
000141114 7001_ $$aGlimelius, Bengt$$b54
000141114 7001_ $$aHjalgrim, Henrik$$b55
000141114 7001_ $$00000-0003-2777-4682$$aPradhan, Nisha$$b56
000141114 7001_ $$00000-0001-5009-4808$$aFeldman, Andrew L$$b57
000141114 7001_ $$aNovak, Anne J$$b58
000141114 7001_ $$aLawrence, Charles$$b59
000141114 7001_ $$aBassig, Bryan A$$b60
000141114 7001_ $$aLan, Qing$$b61
000141114 7001_ $$aZheng, Tongzhang$$b62
000141114 7001_ $$aNorth, Kari E$$b63
000141114 7001_ $$00000-0003-2469-1929$$aTinker, Lesley F$$b64
000141114 7001_ $$aCozen, Wendy$$b65
000141114 7001_ $$aSeverson, Richard K$$b66
000141114 7001_ $$aHofmann, Jonathan N$$b67
000141114 7001_ $$aZhang, Yawei$$b68
000141114 7001_ $$aJackson, Rebecca D$$b69
000141114 7001_ $$aMorton, Lindsay M$$b70
000141114 7001_ $$aPurdue, Mark P$$b71
000141114 7001_ $$aChatterjee, Nilanjan$$b72
000141114 7001_ $$aOffit, Kenneth$$b73
000141114 7001_ $$00000-0002-7482-178X$$aCerhan, James R$$b74
000141114 7001_ $$aChanock, Stephen J$$b75
000141114 7001_ $$aRothman, Nathaniel$$b76
000141114 7001_ $$00000-0002-7933-151X$$aVijai, Joseph$$b77
000141114 7001_ $$aGoldin, Lynn R$$b78
000141114 7001_ $$aSkibola, Christine F$$b79
000141114 7001_ $$aCaporaso, Neil E$$b80
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