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@ARTICLE{McMaster:141114,
      author       = {M. L. McMaster and S. I. Berndt and J. Zhang and S. L.
                      Slager and S. A. Li and C. M. Vajdic and K. E. Smedby and H.
                      Yan and B. M. Birmann and E. E. Brown and A. Smith and G.
                      Kleinstern and M. M. Fansler and C. Mayr and B. Zhu and C.
                      C. Chung and J.-H. Park and L. Burdette and B. D. Hicks and
                      A. Hutchinson and L. R. Teras and H.-O. Adami and P. M.
                      Bracci and J. McKay and A. Monnereau and B. K. Link and R.
                      C. H. Vermeulen and S. M. Ansell and A. Maria and W. R.
                      Diver and M. Melbye and A. I. Ojesina and P. Kraft and P.
                      Boffetta and J. Clavel and E. Giovannucci and C. M. Besson
                      and F. Canzian$^*$ and R. C. Travis and P. Vineis and E.
                      Weiderpass and R. Montalvan and Z. Wang and M. Yeager and N.
                      Becker$^*$ and Y. Benavente and P. Brennan and L. Foretova
                      and M. Maynadie and A. Nieters and S. de Sanjose and A.
                      Staines and L. Conde and J. Riby and B. Glimelius and H.
                      Hjalgrim and N. Pradhan and A. L. Feldman and A. J. Novak
                      and C. Lawrence and B. A. Bassig and Q. Lan and T. Zheng and
                      K. E. North and L. F. Tinker and W. Cozen and R. K. Severson
                      and J. N. Hofmann and Y. Zhang and R. D. Jackson and L. M.
                      Morton and M. P. Purdue and N. Chatterjee and K. Offit and
                      J. R. Cerhan and S. J. Chanock and N. Rothman and J. Vijai
                      and L. R. Goldin and C. F. Skibola and N. E. Caporaso},
      title        = {{T}wo high-risk susceptibility loci at 6p25.3 and 14q32.13
                      for {W}aldenström macroglobulinemia.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2018-01648},
      pages        = {4182},
      year         = {2018},
      abstract     = {Waldenström macroglobulinemia (WM)/lymphoplasmacytic
                      lymphoma (LPL) is a rare, chronic B-cell lymphoma with high
                      heritability. We conduct a two-stage genome-wide association
                      study of WM/LPL in 530 unrelated cases and 4362 controls of
                      European ancestry and identify two high-risk loci associated
                      with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4;
                      OR = 21.14, $95\%$ CI: 14.40-31.03,
                      P = 1.36 × 10-54) and 14q32.13 (rs117410836, near
                      TCL1; OR = 4.90, $95\%$ CI: 3.45-6.96,
                      P = 8.75 × 10-19). Both risk alleles are observed
                      at a low frequency among controls $(~2-3\%)$ and occur in
                      excess in affected cases within families. In silico data
                      suggest that rs116446171 may have functional importance, and
                      in functional studies, we demonstrate increased reporter
                      transcription and proliferation in cells transduced with the
                      6p25.3 risk allele. Although further studies are needed to
                      fully elucidate underlying biological mechanisms, together
                      these loci explain $4\%$ of the familial risk and provide
                      insights into genetic susceptibility to this malignancy.},
      cin          = {C055 / C020},
      ddc          = {500},
      cid          = {I:(DE-He78)C055-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30305637},
      pmc          = {pmc:PMC6180091},
      doi          = {10.1038/s41467-018-06541-2},
      url          = {https://inrepo02.dkfz.de/record/141114},
}