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@ARTICLE{Buffart:141118,
      author       = {L. M. Buffart and M. G. Sweegers and A. M. May and M. J.
                      Chinapaw and J. K. van Vulpen and R. U. Newton and D. A.
                      Galvão and N. K. Aaronson and M. M. Stuiver and P. B.
                      Jacobsen and I. M. Verdonck-de Leeuw and K. Steindorf$^*$
                      and M. L. Irwin and S. Hayes and K. A. Griffith and A. Lucia
                      and F. Herrero-Roman and I. Mesters and E. van Weert and H.
                      Knoop and M. M. Goedendorp and N. Mutrie and A. J. Daley and
                      A. McConnachie and M. Bohus and L. Thorsen and K.-H. Schulz
                      and C. E. Short and E. L. James and R. C. Plotnikoff and G.
                      Arbane and M. E. Schmidt and K. Potthoff and M. van Beurden
                      and H. S. Oldenburg and G. S. Sonke and W. H. van Harten and
                      R. Garrod and K. H. Schmitz and K. M. Winters-Stone and M.
                      J. Velthuis and D. R. Taaffe and W. van Mechelen and M.
                      José Kersten and F. Nollet and J. Wenzel and J. Wiskemann
                      and J. Brug and K. S. Courneya},
      title        = {{T}argeting {E}xercise {I}nterventions to {P}atients {W}ith
                      {C}ancer in {N}eed: {A}n {I}ndividual {P}atient {D}ata
                      {M}eta-{A}nalysis.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {110},
      number       = {11},
      issn         = {1460-2105},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2018-01652},
      pages        = {1190-1200},
      year         = {2018},
      abstract     = {Exercise effects in cancer patients often appear modest,
                      possibly because interventions rarely target patients most
                      in need. This study investigated the moderator effects of
                      baseline values on the exercise outcomes of fatigue, aerobic
                      fitness, muscle strength, quality of life (QoL), and
                      self-reported physical function (PF) in cancer patients
                      during and post-treatment.Individual patient data from 34
                      randomized exercise trials (n = 4519) were pooled.
                      Linear mixed-effect models were used to study moderator
                      effects of baseline values on exercise intervention outcomes
                      and to determine whether these moderator effects differed by
                      intervention timing (during vs post-treatment). All
                      statistical tests were two-sided.Moderator effects of
                      baseline fatigue and PF were consistent across intervention
                      timing, with greater effects in patients with worse fatigue
                      (Pinteraction = .05) and worse PF (Pinteraction = .003).
                      Moderator effects of baseline aerobic fitness, muscle
                      strength, and QoL differed by intervention timing. During
                      treatment, effects on aerobic fitness were greater for
                      patients with better baseline aerobic fitness (Pinteraction
                      = .002). Post-treatment, effects on upper (Pinteraction <
                      .001) and lower (Pinteraction = .01) body muscle strength
                      and QoL (Pinteraction < .001) were greater in patients with
                      worse baseline values.Although exercise should be encouraged
                      for most cancer patients during and post-treatments,
                      targeting specific subgroups may be especially beneficial
                      and cost effective. For fatigue and PF, interventions during
                      and post-treatment should target patients with high fatigue
                      and low PF. During treatment, patients experience benefit
                      for muscle strength and QoL regardless of baseline values;
                      however, only patients with low baseline values benefit
                      post-treatment. For aerobic fitness, patients with low
                      baseline values do not appear to benefit from exercise
                      during treatment.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30299508},
      doi          = {10.1093/jnci/djy161},
      url          = {https://inrepo02.dkfz.de/record/141118},
}