TY  - JOUR
AU  - Gies, Anton
AU  - Cuk, Katarina
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Fecal immunochemical test for hemoglobin in combination with fecal transferrin in colorectal cancer screening.
JO  - United european gastroenterology journal
VL  - 6
IS  - 8
SN  - 2050-6414
CY  - London
PB  - Sage
M1  - DKFZ-2018-01662
SP  - 1223 - 1231
PY  - 2018
AB  - Fecal transferrin has been suggested as a complementary or even superior marker for early detection of colorectal cancer (CRC) besides fecal hemoglobin. We aimed to evaluate both markers individually and in combination in a large cohort of participants of screening colonoscopy.Precolonoscopy stool samples were obtained from participants of screening colonoscopy and frozen at -80℃ until blinded analysis, using a dual-quantitative fecal immunochemical test (FIT) for hemoglobin and transferrin. Sensitivity, specificity and area under the curve (AUC) were calculated for CRC and advanced adenoma (AA).A total of 1667 participants fulfilled our inclusion criteria. All individuals with advanced neoplasm (AN) (16 CRC, 200 AA) and 300 randomly selected participants without AN were included. Mean age was 63 years and 56
LB  - PUB:(DE-HGF)16
C6  - pmid:30288285
C2  - pmc:PMC6169043
DO  - DOI:10.1177/2050640618784053
UR  - https://inrepo02.dkfz.de/record/141131
ER  -