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@ARTICLE{Gies:141131,
      author       = {A. Gies$^*$ and K. Cuk$^*$ and P. Schrotz-King$^*$ and H.
                      Brenner$^*$},
      title        = {{F}ecal immunochemical test for hemoglobin in combination
                      with fecal transferrin in colorectal cancer screening.},
      journal      = {United european gastroenterology journal},
      volume       = {6},
      number       = {8},
      issn         = {2050-6414},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DKFZ-2018-01662},
      pages        = {1223 - 1231},
      year         = {2018},
      abstract     = {Fecal transferrin has been suggested as a complementary or
                      even superior marker for early detection of colorectal
                      cancer (CRC) besides fecal hemoglobin. We aimed to evaluate
                      both markers individually and in combination in a large
                      cohort of participants of screening
                      colonoscopy.Precolonoscopy stool samples were obtained from
                      participants of screening colonoscopy and frozen at -80℃
                      until blinded analysis, using a dual-quantitative fecal
                      immunochemical test (FIT) for hemoglobin and transferrin.
                      Sensitivity, specificity and area under the curve (AUC) were
                      calculated for CRC and advanced adenoma (AA).A total of 1667
                      participants fulfilled our inclusion criteria. All
                      individuals with advanced neoplasm (AN) (16 CRC, 200 AA) and
                      300 randomly selected participants without AN were included.
                      Mean age was 63 years and $56\%$ were male. The AUC for CRC
                      and AA was $92\%$ and $68\%,$ respectively, for hemoglobin
                      vs. $79\%$ and $58\%,$ respectively for transferrin.
                      Combination of both markers yielded an AUC for CRC and AA of
                      $92\%$ and $68\%,$ respectively.FIT for hemoglobin shows
                      better diagnostic performance than FIT for transferrin for
                      the detection of ANs (both proximal and distal neoplasms),
                      and a combination of both markers does not improve the
                      diagnostic performance.},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30288285},
      pmc          = {pmc:PMC6169043},
      doi          = {10.1177/2050640618784053},
      url          = {https://inrepo02.dkfz.de/record/141131},
}