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@ARTICLE{Wei:141146,
      author       = {G. Wei$^*$ and T. Kehl$^*$ and Q. Bao$^*$ and A. Benner$^*$
                      and J. Lei$^*$ and M. Löchelt$^*$},
      title        = {{T}he chromatin binding domain, including the {QPQRYG}
                      motif, of feline foamy virus {G}ag is required for viral
                      {DNA} integration and nuclear accumulation of {G}ag and the
                      viral genome.},
      journal      = {Virology},
      volume       = {524},
      issn         = {0042-6822},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DKFZ-2018-01677},
      pages        = {56 - 68},
      year         = {2018},
      abstract     = {The retroviral Gag protein, the major component of released
                      particles, plays different roles in particle assembly,
                      maturation or infection of new host cells. Here, we
                      characterize the Gag chromatin binding site including the
                      highly conserved QPQRYG motif of feline foamy virus, a
                      member of the Spumaretrovirinae. Mutagenesis of critical
                      residues in the chromatin binding site/QPQRYG motif almost
                      completely abrogates viral DNA integration and reduces
                      nuclear accumulation of Gag and viral DNA. Genome packaging,
                      reverse transcription, particle release and uptake into new
                      target cells are not affected. The integrity of the QPQRYG
                      motif appears to be important for processes after cytosolic
                      entry, likely influencing incoming virus capsids or
                      disassembly intermediates but not Gag synthesized de novo in
                      progeny virus-producing cells. According to our data,
                      chromatin binding is a shared feature among foamy viruses
                      but further work is needed to understand the mechanisms
                      involved.},
      cin          = {F020 / V155 / C060},
      ddc          = {570},
      cid          = {I:(DE-He78)F020-20160331 / I:(DE-He78)V155-20160331 /
                      I:(DE-He78)C060-20160331},
      pnm          = {316 - Infections and cancer (POF3-316)},
      pid          = {G:(DE-HGF)POF3-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30145377},
      doi          = {10.1016/j.virol.2018.08.007},
      url          = {https://inrepo02.dkfz.de/record/141146},
}