TY  - JOUR
AU  - Watts, Eleanor L
AU  - Appleby, Paul N
AU  - Perez-Cornago, Aurora
AU  - Bueno-de-Mesquita, H Bas
AU  - Chan, June M
AU  - Chen, Chu
AU  - Cohn, Barbara A
AU  - Cook, Michael B
AU  - Flicker, Leon
AU  - Freedman, Neal D
AU  - Giles, Graham G
AU  - Giovannucci, Edward
AU  - Gislefoss, Randi E
AU  - Hankey, Graeme J
AU  - Kaaks, Rudolf
AU  - Knekt, Paul
AU  - Kolonel, Laurence N
AU  - Kubo, Tatsuhiko
AU  - Le Marchand, Loïc
AU  - Luben, Robert N
AU  - Luostarinen, Tapio
AU  - Männistö, Satu
AU  - Metter, E Jeffrey
AU  - Mikami, Kazuya
AU  - Milne, Roger L
AU  - Ozasa, Kotaro
AU  - Platz, Elizabeth A
AU  - Quirós, J Ramón
AU  - Rissanen, Harri
AU  - Sawada, Norie
AU  - Stampfer, Meir
AU  - Stanczyk, Frank Z
AU  - Stattin, Pär
AU  - Tamakoshi, Akiko
AU  - Tangen, Catherine M
AU  - Thompson, Ian M
AU  - Tsilidis, Konstantinos K
AU  - Tsugane, Shoichiro
AU  - Ursin, Giske
AU  - Vatten, Lars
AU  - Weiss, Noel S
AU  - Yeap, Bu B
AU  - Allen, Naomi E
AU  - Key, Timothy J
AU  - Travis, Ruth C
TI  - Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies.
JO  - European urology
VL  - 74
IS  - 5
SN  - 0302-2838
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2018-01687
SP  - 585 - 594
PY  - 2018
AB  - Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting.To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer.Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group.Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration.Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:30077399
DO  - DOI:10.1016/j.eururo.2018.07.024
UR  - https://inrepo02.dkfz.de/record/141156
ER  -