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@ARTICLE{Watts:141156,
author = {E. L. Watts and P. N. Appleby and A. Perez-Cornago and H.
B. Bueno-de-Mesquita and J. M. Chan and C. Chen and B. A.
Cohn and M. B. Cook and L. Flicker and N. D. Freedman and G.
G. Giles and E. Giovannucci and R. E. Gislefoss and G. J.
Hankey and R. Kaaks$^*$ and P. Knekt and L. N. Kolonel and
T. Kubo and L. Le Marchand and R. N. Luben and T.
Luostarinen and S. Männistö and E. J. Metter and K. Mikami
and R. L. Milne and K. Ozasa and E. A. Platz and J. R.
Quirós and H. Rissanen and N. Sawada and M. Stampfer and F.
Z. Stanczyk and P. Stattin and A. Tamakoshi and C. M. Tangen
and I. M. Thompson and K. K. Tsilidis and S. Tsugane and G.
Ursin and L. Vatten and N. S. Weiss and B. B. Yeap and N. E.
Allen and T. J. Key and R. C. Travis},
title = {{L}ow {F}ree {T}estosterone and {P}rostate {C}ancer {R}isk:
{A} {C}ollaborative {A}nalysis of 20 {P}rospective
{S}tudies.},
journal = {European urology},
volume = {74},
number = {5},
issn = {0302-2838},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Science},
reportid = {DKFZ-2018-01687},
pages = {585 - 594},
year = {2018},
abstract = {Experimental and clinical evidence implicates testosterone
in the aetiology of prostate cancer. Variation across the
normal range of circulating free testosterone concentrations
may not lead to changes in prostate biology, unless
circulating concentrations are low. This may also apply to
prostate cancer risk, but this has not been investigated in
an epidemiological setting.To examine whether men with low
concentrations of circulating free testosterone have a
reduced risk of prostate cancer.Analysis of individual
participant data from 20 prospective studies including 6933
prostate cancer cases, diagnosed on average 6.8 yr after
blood collection, and 12 088 controls in the Endogenous
Hormones, Nutritional Biomarkers and Prostate Cancer
Collaborative Group.Odds ratios (ORs) of incident overall
prostate cancer and subtypes by stage and grade, using
conditional logistic regression, based on study-specific
tenths of calculated free testosterone concentration.Men in
the lowest tenth of free testosterone concentration had a
lower risk of overall prostate cancer (OR=0.77, $95\%$
confidence interval [CI] 0.69-0.86; p<0.001) compared with
men with higher concentrations (2nd-10th tenths of the
distribution). Heterogeneity was present by tumour grade
(phet=0.01), with a lower risk of low-grade disease
(OR=0.76, $95\%$ CI 0.67-0.88) and a nonsignificantly higher
risk of high-grade disease (OR=1.56, $95\%$ CI 0.95-2.57).
There was no evidence of heterogeneity by tumour stage. The
observational design is a limitation.Men with low
circulating free testosterone may have a lower risk of
overall prostate cancer; this may be due to a direct
biological effect, or detection bias. Further research is
needed to explore the apparent differential association by
tumour grade.In this study, we looked at circulating
testosterone levels and risk of developing prostate cancer,
finding that men with low testosterone had a lower risk of
prostate cancer.},
subtyp = {Editorial},
cin = {C020},
ddc = {610},
cid = {I:(DE-He78)C020-20160331},
pnm = {313 - Cancer risk factors and prevention (POF3-313)},
pid = {G:(DE-HGF)POF3-313},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30077399},
doi = {10.1016/j.eururo.2018.07.024},
url = {https://inrepo02.dkfz.de/record/141156},
}