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000141171 0247_ $$2pmc$$apmc:PMC6182397
000141171 0247_ $$2ISSN$$a0340-6997
000141171 0247_ $$2ISSN$$a1432-105X
000141171 0247_ $$2ISSN$$a1619-7070
000141171 0247_ $$2ISSN$$a1619-7089
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000141171 037__ $$aDKFZ-2018-01698
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000141171 1001_ $$aAfshar-Oromieh, Ali$$b0
000141171 245__ $$aImpact of long-term androgen deprivation therapy on PSMA ligand PET/CT in patients with castration-sensitive prostate cancer.060
000141171 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2018
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000141171 520__ $$aSince the introduction of PSMA PET/CT with 68Ga-PSMA-11, this modality for imaging prostate cancer (PC) has spread worldwide. Preclinical studies have demonstrated that short-term androgen deprivation therapy (ADT) can significantly increase PSMA expression on PC cells. Additionally, retrospective clinical data in large patient cohorts suggest a positive association between ongoing ADT and a pathological PSMA PET/CT scan. The present evaluation was conducted to further analyse the influence of long-term ADT on PSMA PET/CT findings.A retrospective analysis was performed of all 1,704 patients who underwent a 68Ga-PSMA-11 PET/CT scan at our institution from 2011 to 2017 to detect PC. Of 306 patients scanned at least twice, 10 had started and continued ADT with a continuous clinical response between the two PSMA PET/CT scans. These ten patients were included in the current analysis which compared the tracer uptake intensity and volume of PC lesions on PSMA PET/CT before and during ongoing ADT.Overall, 31 PC lesions were visible in all ten patients before initiation of ADT. However, during ongoing ADT (duration 42-369 days, median 230 days), only 14 lesions were visible in eight of the ten patients. The average tracer uptake values decreased in 71% and increased in 12.9% of the PC lesions. Of all lesions, 33.3% were still visible in six patients with a complete PSA response (≤0.1 ng/ml).Continuous long-term ADT significantly reduces the visibility of castration-sensitive PC on PSMA PET/CT. If the objective is visualization of the maximum possible extent of disease, we recommend referring patients for PSMA PET/CT before starting ADT.
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000141171 7001_ $$aDebus, Nils$$b1
000141171 7001_ $$0P:(DE-He78)1fb1300fe0ab9b45defcb93300ea3299$$aUhrig, Monika$$b2$$udkfz
000141171 7001_ $$aHope, Thomas A$$b3
000141171 7001_ $$aEvans, Michael J$$b4
000141171 7001_ $$0P:(DE-He78)457c042884c901eb0a02c18bb1d30103$$aHolland-Letz, Tim$$b5$$udkfz
000141171 7001_ $$aGiesel, Frederik L$$b6
000141171 7001_ $$0P:(DE-He78)9793347ba83f527b81a22ab75af9378a$$aKopka, Klaus$$b7$$udkfz
000141171 7001_ $$aHadaschik, Boris$$b8
000141171 7001_ $$aKratochwil, Clemens$$b9
000141171 7001_ $$0P:(DE-He78)13a0afba029f5f64dc18b25ef7499558$$aHaberkorn, Uwe$$b10$$eLast author$$udkfz
000141171 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-018-4079-z$$gVol. 45, no. 12, p. 2045 - 2054$$n12$$p2045 - 2054$$tEuropean journal of nuclear medicine and molecular imaging$$v45$$x1619-7089$$y2018
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