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@ARTICLE{Brenner:141178,
      author       = {H. Brenner$^*$ and C. Chen$^*$},
      title        = {{T}he colorectal cancer epidemic: challenges and
                      opportunities for primary, secondary and tertiary
                      prevention.},
      journal      = {British journal of cancer},
      volume       = {119},
      number       = {7},
      issn         = {1532-1827},
      address      = {Edinburgh},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2018-01705},
      pages        = {785 - 792},
      year         = {2018},
      abstract     = {Colorectal cancer (CRC) is both one of the most common and
                      one of the most preventable cancers globally, with powerful
                      but strongly missed potential for primary, secondary and
                      tertiary prevention. CRC incidence has traditionally been
                      the highest in affluent Western countries, but it is now
                      increasing rapidly with economic development in many other
                      parts of the world. CRC shares several main risk factors,
                      such as smoking, excessive alcohol consumption, physical
                      inactivity and being overweight, with other common diseases;
                      therefore, primary prevention efforts to reduce these risk
                      factors are expected to have multiple beneficial effects
                      that extend beyond CRC prevention, and should have high
                      public health impact. A sizeable reduction in the incidence
                      and mortality of CRC can also be achieved by offering
                      effective screening tests, such as faecal immunochemical
                      tests, flexible sigmoidoscopy and colonoscopy, in organised
                      screening programmes which have been implemented in an
                      increasing number of countries. Countries with early and
                      high uptake rates of effective screening have exhibited
                      major declines in CRC incidence and mortality, in contrast
                      to most other countries. Finally, increasing evidence shows
                      that the prognosis and quality of life of CRC patients can
                      be substantially improved by tertiary prevention measures,
                      such as the administration of low-dose aspirin and the
                      promotion of physical activity.},
      subtyp        = {Review Article},
      cin          = {C070 / G110 / L101},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30287914},
      doi          = {10.1038/s41416-018-0264-x},
      url          = {https://inrepo02.dkfz.de/record/141178},
}