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| Home > Publications database > NK-cell responses are biased towards CD16-mediated effector functions in chronic Hepatitis B virus infection. > print |
| 001 | 141188 | ||
| 005 | 20240229112523.0 | ||
| 024 | 7 | _ | |a 10.1016/j.jhep.2018.10.006 |2 doi |
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| 024 | 7 | _ | |a 0168-8278 |2 ISSN |
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| 037 | _ | _ | |a DKFZ-2018-01711 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Schuch, Anita |b 0 |
| 245 | _ | _ | |a NK-cell responses are biased towards CD16-mediated effector functions in chronic Hepatitis B virus infection. |
| 260 | _ | _ | |a [S.l.] |c 2019 |b Wiley-Blackwell |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1551857197_6106 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Phenotypical and functional NK-cell alterations are well described in chronic Hepatitis B virus (cHBV) infection. However, it is largely unknown whether these alterations result from general effects on the overall NK-cell population or the emergence of distinct NK-cell subsets. Indeed, memory-like NK cells emerge in association with human cytomegalovirus (HCMV) infection that is common in cHBV infection. These memory-like NK cells display an altered phenotype and functionality including superior CD16-mediated effector functions.To assess the impact of memory-like NK cells on phenotypic and functional alterations in cHBV infection we performed in-depth analyses of circulating NK cells in 52 cHBV patients, 45 chronically HCV-infected patients and 50 healthy donors (HD) with respect to their HCMV serostatus.In cHBV/HCMV+ patients, FcεRIγ- memory-like NK cells were present in higher frequencies and with higher prevalence compared to HD/HCMV+. This pronounced HCMV-associated memory-like NK-cell expansion could be identified as key determinant of the NK-cell response in cHBV infection. Furthermore, we observed that memory-like NK cells consist of epigenetically distinct subsets and exhibit metabolic key characteristics of long-living cells. Despite ongoing chronic infection, the phenotype of memory-like NK cells was conserved in cHBV/HCMV+ patients. Functional characteristics of memory-like NK cells also remained largely unaffected by cHBV infection with the exception of an increased degranulation capacity in response to CD16 stimulation that was, however, detectable in both, memory-like and conventional NK cells.The emergence of HCMV-associated memory-like NK cells shapes the overall NK-cell response in cHBV infection and contributes to a general shift towards CD16-mediated effector functions. HCMV coinfection therefore needs to be considered with respect to the design of immunotherapeutic approaches in HBV cure targeting NK cells.In chronic hepatitis B virus infection, the NK-cell phenotype and function is altered in comparison to healthy donors. In this study, we demonstrate that this is linked to the emergence of a distinct NK-cell subset, namely memory-like NK cells. The emergence of these memory-like NK cells is associated with co-infection of human cytomegalovirus that affects the majority of patients with chronic hepatitis B. |
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| 700 | 1 | _ | |a Zecher, Britta Franziska |b 1 |
| 700 | 1 | _ | |a Müller, Philipp Andreas |b 2 |
| 700 | 1 | _ | |a Correia, Margareta P |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Daul, Franziska |b 4 |
| 700 | 1 | _ | |a Rennert, Charlotte |b 5 |
| 700 | 1 | _ | |a Tauber, Catrin |b 6 |
| 700 | 1 | _ | |a Schlitt, Karolin |b 7 |
| 700 | 1 | _ | |a Boettler, Tobias |b 8 |
| 700 | 1 | _ | |a Neumann-Haefelin, Christoph |b 9 |
| 700 | 1 | _ | |a Hengel, Hartmut |b 10 |
| 700 | 1 | _ | |a Pircher, Hanspeter |b 11 |
| 700 | 1 | _ | |a Cerwenka, Adelheid |0 P:(DE-He78)d2b4dd8bdffe4aaa0f5e30e91587766f |b 12 |u dkfz |
| 700 | 1 | _ | |a Thimme, Robert |b 13 |
| 700 | 1 | _ | |a Hofmann, Maike |b 14 |
| 773 | _ | _ | |a 10.1016/j.jhep.2018.10.006 |g p. S0168827818324589 |0 PERI:(DE-600)2027112-8 |n 3 |p 351-360 |t Journal of hepatology |v 70 |y 2019 |x 0168-8278 |
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| 915 | _ | _ | |a Nationallizenz |0 StatID:(DE-HGF)0420 |2 StatID |
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