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000141192 1001_ $$aWard, Heather A$$b0
000141192 245__ $$aHaem iron intake and risk of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
000141192 260__ $$aNew York, NY$$bNature Publ. Group$$c2019
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000141192 520__ $$aEpidemiological studies suggest that haem iron, which is found predominantly in red meat and increases endogenous formation of carcinogenic N-nitroso compounds, may be positively associated with lung cancer. The objective was to examine the relationship between haem iron intake and lung cancer risk using detailed smoking history data and serum cotinine to control for potential confounding.In the European Prospective Investigation into Cancer and Nutrition (EPIC), 416,746 individuals from 10 countries completed demographic and dietary questionnaires at recruitment. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident lung cancer (n = 3731) risk relative to haem iron, non-haem iron, and total dietary iron intake. A corresponding analysis was conducted among a nested subset of 800 lung cancer cases and 1489 matched controls for whom serum cotinine was available.Haem iron was associated with lung cancer risk, including after adjustment for details of smoking history (time since quitting, number of cigarettes per day): as a continuous variable (HR per 0.3 mg/1000 kcal 1.03, 95% CI 1.00-1.07), and in the highest versus lowest quintile (HR 1.16, 95% CI 1.02-1.32; trend across quintiles: P = 0.035). In contrast, non-haem iron intake was related inversely with lung cancer risk; however, this association attenuated after adjustment for smoking history. Additional adjustment for serum cotinine did not considerably alter the associations detected in the nested case-control subset.Greater haem iron intake may be modestly associated with lung cancer risk.
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000141192 7001_ $$aWhitman, Julia$$b1
000141192 7001_ $$aMuller, David C$$b2
000141192 7001_ $$aJohansson, Mattias$$b3
000141192 7001_ $$aJakszyn, Paula$$b4
000141192 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b5
000141192 7001_ $$aPalli, Domenico$$b6
000141192 7001_ $$aFanidi, Anouar$$b7
000141192 7001_ $$aVermeulen, Roel$$b8
000141192 7001_ $$aTjønneland, Anne$$b9
000141192 7001_ $$aHansen, Louise$$b10
000141192 7001_ $$aDahm, Christina C$$b11
000141192 7001_ $$aOvervad, Kim$$b12
000141192 7001_ $$aSeveri, Gianluca$$b13
000141192 7001_ $$aBoutron-Ruault, Marie-Christine$$b14
000141192 7001_ $$aAffret, Aurélie$$b15
000141192 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b16$$udkfz
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000141192 7001_ $$aBoeing, Heiner$$b18
000141192 7001_ $$aTrichopoulou, Antonia$$b19
000141192 7001_ $$aLa Vecchia, Carlo$$b20
000141192 7001_ $$aKotanidou, Anastasia$$b21
000141192 7001_ $$aBerrino, Franco$$b22
000141192 7001_ $$aKrogh, Vittorio$$b23
000141192 7001_ $$aTumino, Rosario$$b24
000141192 7001_ $$aRicceri, Fulvio$$b25
000141192 7001_ $$aPanico, Salvatore$$b26
000141192 7001_ $$aBueno-de-Mesquita, H Bas$$b27
000141192 7001_ $$aPeeters, Petra H$$b28
000141192 7001_ $$aNøst, Therese Haugdahl$$b29
000141192 7001_ $$aSandanger, Torkjel M$$b30
000141192 7001_ $$aQuirós, Jose Ramón$$b31
000141192 7001_ $$aAgudo, Antonio$$b32
000141192 7001_ $$aRodríguez-Barranco, Miguel$$b33
000141192 7001_ $$aLarrañaga, Nerea$$b34
000141192 7001_ $$aHuerta, Jose Maria$$b35
000141192 7001_ $$aArdanaz, Eva$$b36
000141192 7001_ $$aDrake, Isabel$$b37
000141192 7001_ $$aBrunnström, Hans$$b38
000141192 7001_ $$aJohansson, Mikael$$b39
000141192 7001_ $$00000-0003-4289-2097$$aGrankvist, Kjell$$b40
000141192 7001_ $$aTravis, Ruth C$$b41
000141192 7001_ $$aFreisling, Heinz$$b42
000141192 7001_ $$aStepien, Magdalena$$b43
000141192 7001_ $$aMerritt, Melissa A$$b44
000141192 7001_ $$aRiboli, Elio$$b45
000141192 7001_ $$aCross, Amanda J$$b46
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