000141257 001__ 141257
000141257 005__ 20240229105123.0
000141257 0247_ $$2doi$$a10.1016/j.cgh.2018.05.043
000141257 0247_ $$2pmid$$apmid:29902640
000141257 0247_ $$2ISSN$$a1542-3565
000141257 0247_ $$2ISSN$$a1542-7714
000141257 0247_ $$2altmetric$$aaltmetric:51242078
000141257 037__ $$aDKFZ-2018-01777
000141257 041__ $$aeng
000141257 082__ $$a610
000141257 1001_ $$aRösch, Thomas$$b0
000141257 245__ $$aRisk of Malignancy in Adenomas Detected During Screening Colonoscopy.
000141257 260__ $$aNew York, NY$$bElsevier Science$$c2018
000141257 3367_ $$2DRIVER$$aarticle
000141257 3367_ $$2DataCite$$aOutput Types/Journal article
000141257 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1660123158_9237
000141257 3367_ $$2BibTeX$$aARTICLE
000141257 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000141257 3367_ $$00$$2EndNote$$aJournal Article
000141257 520__ $$aA higher incidence of proximal interval cancers after colonoscopy has been reported in several follow-up studies. One possible explanation for this might be that proximally located adenomas have greater malignant potential. The aim of the present study was to assess the risk of malignancy in proximal versus distal adenomas in patients included in a large screening colonoscopy database; adenoma shape and the patients' age and sex distribution were also analyzed.Data for 2007-2012 from the German National Screening Colonoscopy Registry, including 594,614 adenomas identified during 2,532,298 screening colonoscopies, were analyzed retrospectively. The main outcome measure was the rate of high-grade dysplasia (HGD) in adenomas, used as a surrogate marker for the risk of malignancy. Odds ratios (ORs) for the rate of HGD found in adenomas were analyzed in relation to patient- and adenoma-related factors using multivariate analysis.HGD histology was noted in 20,873 adenomas (3.5%). Proximal adenoma locations were not associated with a higher HGD rate. The most significant risk factor for HGD was adenoma size (OR 10.36 ≥1 cm vs <1 cm), followed by patient age (OR 1.26 and 1.46 for age groups 65-74 and 75-84 vs 55-64 years) and sex (OR 1.15 male vs female). In comparison with flat adenomas as a reference lesion, sessile lesions had a similar HGD rate (OR 1.02) and pedunculated adenomas had a higher rate (OR 1.23). All associations were statistically significant (P ≤ .05).In this large screening database, it was found that the rates of adenomas with HGD are similar in the proximal and distal colon. The presence of HGD as a risk marker alone does not explain higher rates of proximal interval colorectal cancer. We suggest that certain lesions (flat, serrated lesions) may be missed in the proximal colon and may acquire a more aggressive biology over time. A combination of endoscopy-related factors and biology may therefore account for higher rates of proximal versus distal interval colorectal cancer.
000141257 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000141257 588__ $$aDataset connected to CrossRef, PubMed,
000141257 7001_ $$aAltenhofen, Lutz$$b1
000141257 7001_ $$aKretschmann, Jens$$b2
000141257 7001_ $$aHagen, Bernd$$b3
000141257 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b4$$udkfz
000141257 7001_ $$aPox, Christian$$b5
000141257 7001_ $$aSchmiegel, Wolff$$b6
000141257 7001_ $$aTheilmeier, Arno$$b7
000141257 7001_ $$aAschenbeck, Jens$$b8
000141257 7001_ $$aTannapfel, Andrea$$b9
000141257 7001_ $$avon Stillfried, Dominik$$b10
000141257 7001_ $$aZimmermann-Fraedrich, Katharina$$b11
000141257 7001_ $$aWegscheider, Karl$$b12
000141257 773__ $$0PERI:(DE-600)2102638-5$$a10.1016/j.cgh.2018.05.043$$gVol. 16, no. 11, p. 1754 - 1761$$n11$$p1754 - 1761$$tClinical gastroenterology and hepatology$$v16$$x1542-3565$$y2018
000141257 909CO $$ooai:inrepo02.dkfz.de:141257$$pVDB
000141257 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b4$$kDKFZ
000141257 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000141257 9141_ $$y2018
000141257 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCLIN GASTROENTEROL H : 2017
000141257 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000141257 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000141257 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000141257 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000141257 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000141257 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000141257 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000141257 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bCLIN GASTROENTEROL H : 2017
000141257 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000141257 9201_ $$0I:(DE-He78)G110-20160331$$kG110$$lPräventive Onkologie$$x1
000141257 9201_ $$0I:(DE-He78)L101-20160331$$kL101$$lDKTK Heidelberg$$x2
000141257 980__ $$ajournal
000141257 980__ $$aVDB
000141257 980__ $$aI:(DE-He78)C070-20160331
000141257 980__ $$aI:(DE-He78)G110-20160331
000141257 980__ $$aI:(DE-He78)L101-20160331
000141257 980__ $$aUNRESTRICTED