TY  - JOUR
AU  - Rösch, Thomas
AU  - Altenhofen, Lutz
AU  - Kretschmann, Jens
AU  - Hagen, Bernd
AU  - Brenner, Hermann
AU  - Pox, Christian
AU  - Schmiegel, Wolff
AU  - Theilmeier, Arno
AU  - Aschenbeck, Jens
AU  - Tannapfel, Andrea
AU  - von Stillfried, Dominik
AU  - Zimmermann-Fraedrich, Katharina
AU  - Wegscheider, Karl
TI  - Risk of Malignancy in Adenomas Detected During Screening Colonoscopy.
JO  - Clinical gastroenterology and hepatology
VL  - 16
IS  - 11
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2018-01777
SP  - 1754 - 1761
PY  - 2018
AB  - A higher incidence of proximal interval cancers after colonoscopy has been reported in several follow-up studies. One possible explanation for this might be that proximally located adenomas have greater malignant potential. The aim of the present study was to assess the risk of malignancy in proximal versus distal adenomas in patients included in a large screening colonoscopy database; adenoma shape and the patients' age and sex distribution were also analyzed.Data for 2007-2012 from the German National Screening Colonoscopy Registry, including 594,614 adenomas identified during 2,532,298 screening colonoscopies, were analyzed retrospectively. The main outcome measure was the rate of high-grade dysplasia (HGD) in adenomas, used as a surrogate marker for the risk of malignancy. Odds ratios (ORs) for the rate of HGD found in adenomas were analyzed in relation to patient- and adenoma-related factors using multivariate analysis.HGD histology was noted in 20,873 adenomas (3.5
LB  - PUB:(DE-HGF)16
C6  - pmid:29902640
DO  - DOI:10.1016/j.cgh.2018.05.043
UR  - https://inrepo02.dkfz.de/record/141257
ER  -