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@ARTICLE{ZamoraRos:141260,
      author       = {R. Zamora-Ros and V. Cayssials and M. Jenab and J. A.
                      Rothwell and V. Fedirko and K. Aleksandrova and A.
                      Tjønneland and C. Kyrø and K. Overvad and M.-C.
                      Boutron-Ruault and F. Carbonnel and Y. Mahamat-Saleh and R.
                      Kaaks$^*$ and T. Kühn$^*$ and H. Boeing and A. Trichopoulou
                      and E. Valanou and E. Vasilopoulou and G. Masala and V. Pala
                      and S. Panico and R. Tumino and F. Ricceri and E. Weiderpass
                      and M. Lukic and T. M. Sandanger and C. Lasheras and A.
                      Agudo and M.-J. Sánchez and P. Amiano and C. Navarro and E.
                      Ardanaz and E. Sonestedt and B. Ohlsson and L. M. Nilsson
                      and M. Rutegård and B. Bueno-de-Mesquita and P. H. Peeters
                      and K.-T. Khaw and N. J. Wareham and K. Bradbury and H.
                      Freisling and I. Romieu and A. J. Cross and P. Vineis and A.
                      Scalbert},
      title        = {{D}ietary intake of total polyphenol and polyphenol classes
                      and the risk of colorectal cancer in the {E}uropean
                      {P}rospective {I}nvestigation into {C}ancer and {N}utrition
                      ({EPIC}) cohort.},
      journal      = {European journal of epidemiology},
      volume       = {33},
      number       = {11},
      issn         = {1573-7284},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2018-01780},
      pages        = {1063 - 1075},
      year         = {2018},
      abstract     = {Polyphenols may play a chemopreventive role in colorectal
                      cancer (CRC); however, epidemiological evidence supporting a
                      role for intake of individual polyphenol classes, other than
                      flavonoids is insufficient. We evaluated the association
                      between dietary intakes of total and individual classes and
                      subclasses of polyphenols and CRC risk and its main
                      subsites, colon and rectum, within the European Prospective
                      Investigation into Cancer and Nutrition (EPIC) study. The
                      cohort included 476,160 men and women from 10 European
                      countries. During a mean follow-up of 14 years, there were
                      5991 incident CRC cases, of which 3897 were in the colon and
                      2094 were in the rectum. Polyphenol intake was estimated
                      using validated centre/country specific dietary
                      questionnaires and the Phenol-Explorer database. In
                      multivariable-adjusted Cox regression models, a doubling in
                      total dietary polyphenol intake was not associated with CRC
                      risk in women (HRlog2 = 1.06, $95\%$ CI 0.99-1.14) or in
                      men (HRlog2 = 0.97, $95\%$ CI 0.90-1.05), respectively.
                      Phenolic acid intake, highly correlated with coffee
                      consumption, was inversely associated with colon cancer in
                      men (HRlog2 = 0.91, $95\%$ CI 0.85-0.97) and positively
                      associated with rectal cancer in women (HRlog2 = 1.10,
                      $95\%$ CI 1.02-1.19); although associations did not exceed
                      the Bonferroni threshold for significance. Intake of other
                      polyphenol classes was not related to colorectal, colon or
                      rectal cancer risks. Our study suggests a possible inverse
                      association between phenolic acid intake and colon cancer
                      risk in men and positive with rectal cancer risk in women.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29761424},
      doi          = {10.1007/s10654-018-0408-6},
      url          = {https://inrepo02.dkfz.de/record/141260},
}