000141261 001__ 141261
000141261 005__ 20240229105123.0
000141261 0247_ $$2doi$$a10.1177/1352458517728342
000141261 0247_ $$2pmid$$apmid:28825348
000141261 0247_ $$2ISSN$$a1352-4585
000141261 0247_ $$2ISSN$$a1477-0970
000141261 0247_ $$2altmetric$$aaltmetric:24173278
000141261 037__ $$aDKFZ-2018-01781
000141261 041__ $$aeng
000141261 082__ $$a610
000141261 1001_ $$0P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aZimmer, Philipp$$b0$$eFirst author$$udkfz
000141261 245__ $$aHigh-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial.
000141261 260__ $$aLondon$$bSage$$c2018
000141261 3367_ $$2DRIVER$$aarticle
000141261 3367_ $$2DataCite$$aOutput Types/Journal article
000141261 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1541414772_32257
000141261 3367_ $$2BibTeX$$aARTICLE
000141261 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000141261 3367_ $$00$$2EndNote$$aJournal Article
000141261 520__ $$aAerobic exercise can improve cognitive performance in healthy elderly people.The aim of this study was to investigate the influence of a 3-week high-intensity aerobic exercise programme (high-intensity training group (HIT)) on cognitive performance in persons with multiple sclerosis (MS) compared with a standard exercise programme (control training (CT)).A total of 60 persons with MS (Expanded Disability Status Scale (EDSS): 1.0-6.5) were randomized to a HIT group (3×/week for 20 minutes, including five 3-minute exercise intervals at 80% of peak oxygen uptake (VO2-peak)) or a CT group (continuously 5×/week for 30 minutes/session at 65% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS at entry ( t0) and discharge ( t1). Furthermore, VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and -9 were measured.Compared to CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both groups. Secondary outcomes indicated significant improvements in VO2-peak and a significant reduction in MMP-2 in the HIT group only.HIT represents a promising strategy to improve verbal memory and physical fitness in persons with MS. Further research is needed to determine the impact of exercise on biomarkers in MS.
000141261 536__ $$0G:(DE-HGF)POF3-317$$a317 - Translational cancer research (POF3-317)$$cPOF3-317$$fPOF III$$x0
000141261 588__ $$aDataset connected to CrossRef, PubMed,
000141261 7001_ $$aBloch, Wilhelm$$b1
000141261 7001_ $$aSchenk, Alexander$$b2
000141261 7001_ $$aOberste, Max$$b3
000141261 7001_ $$aRiedel, Stefan$$b4
000141261 7001_ $$aKool, Jan$$b5
000141261 7001_ $$aLangdon, Dawn$$b6
000141261 7001_ $$aDalgas, Ulrik$$b7
000141261 7001_ $$aKesselring, Jürg$$b8
000141261 7001_ $$aBansi, Jens$$b9
000141261 773__ $$0PERI:(DE-600)2008225-3$$a10.1177/1352458517728342$$gVol. 24, no. 12, p. 1635 - 1644$$n12$$p1635 - 1644$$tMultiple sclerosis journal$$v24$$x1477-0970$$y2018
000141261 909CO $$ooai:inrepo02.dkfz.de:141261$$pVDB
000141261 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d05b24af674d8ef2c455634434b67770$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000141261 9131_ $$0G:(DE-HGF)POF3-317$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vTranslational cancer research$$x0
000141261 9141_ $$y2018
000141261 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz
000141261 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000141261 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bMULT SCLER J : 2017
000141261 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000141261 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000141261 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000141261 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000141261 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000141261 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000141261 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000141261 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000141261 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000141261 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000141261 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000141261 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000141261 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bMULT SCLER J : 2017
000141261 9201_ $$0I:(DE-He78)G210-20160331$$kG210$$lBewegung, Präventionsforschung und Krebs$$x0
000141261 980__ $$ajournal
000141261 980__ $$aVDB
000141261 980__ $$aI:(DE-He78)G210-20160331
000141261 980__ $$aUNRESTRICTED