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@ARTICLE{Zimmer:141261,
      author       = {P. Zimmer$^*$ and W. Bloch and A. Schenk and M. Oberste and
                      S. Riedel and J. Kool and D. Langdon and U. Dalgas and J.
                      Kesselring and J. Bansi},
      title        = {{H}igh-intensity interval exercise improves cognitive
                      performance and reduces matrix metalloproteinases-2 serum
                      levels in persons with multiple sclerosis: {A} randomized
                      controlled trial.},
      journal      = {Multiple sclerosis journal},
      volume       = {24},
      number       = {12},
      issn         = {1477-0970},
      address      = {London},
      publisher    = {Sage},
      reportid     = {DKFZ-2018-01781},
      pages        = {1635 - 1644},
      year         = {2018},
      abstract     = {Aerobic exercise can improve cognitive performance in
                      healthy elderly people.The aim of this study was to
                      investigate the influence of a 3-week high-intensity aerobic
                      exercise programme (high-intensity training group (HIT)) on
                      cognitive performance in persons with multiple sclerosis
                      (MS) compared with a standard exercise programme (control
                      training (CT)).A total of 60 persons with MS (Expanded
                      Disability Status Scale (EDSS): 1.0-6.5) were randomized to
                      a HIT group (3×/week for 20 minutes, including five
                      3-minute exercise intervals at $80\%$ of peak oxygen uptake
                      (VO2-peak)) or a CT group (continuously 5×/week for
                      30 minutes/session at $65\%$ of VO2-peak). Cognitive
                      performance was assessed using the Brief International
                      Cognitive Assessment for MS at entry ( t0) and discharge (
                      t1). Furthermore, VO2-peak, brain-derived neurotrophic
                      factor, serotonin and matrix metalloproteinases (MMP)-2 and
                      -9 were measured.Compared to CT, HIT significantly improved
                      verbal memory. Significant improvements over time in
                      executive functions were found in both groups. Secondary
                      outcomes indicated significant improvements in VO2-peak and
                      a significant reduction in MMP-2 in the HIT group only.HIT
                      represents a promising strategy to improve verbal memory and
                      physical fitness in persons with MS. Further research is
                      needed to determine the impact of exercise on biomarkers in
                      MS.},
      cin          = {G210},
      ddc          = {610},
      cid          = {I:(DE-He78)G210-20160331},
      pnm          = {317 - Translational cancer research (POF3-317)},
      pid          = {G:(DE-HGF)POF3-317},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28825348},
      doi          = {10.1177/1352458517728342},
      url          = {https://inrepo02.dkfz.de/record/141261},
}