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| 005 | 20240229105123.0 | ||
| 024 | 7 | _ | |a 10.1177/1352458517728342 |2 doi |
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| 024 | 7 | _ | |a 1352-4585 |2 ISSN |
| 024 | 7 | _ | |a 1477-0970 |2 ISSN |
| 024 | 7 | _ | |a altmetric:24173278 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2018-01781 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zimmer, Philipp |0 P:(DE-He78)d05b24af674d8ef2c455634434b67770 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial. |
| 260 | _ | _ | |a London |c 2018 |b Sage |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1541414772_32257 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a Aerobic exercise can improve cognitive performance in healthy elderly people.The aim of this study was to investigate the influence of a 3-week high-intensity aerobic exercise programme (high-intensity training group (HIT)) on cognitive performance in persons with multiple sclerosis (MS) compared with a standard exercise programme (control training (CT)).A total of 60 persons with MS (Expanded Disability Status Scale (EDSS): 1.0-6.5) were randomized to a HIT group (3×/week for 20 minutes, including five 3-minute exercise intervals at 80% of peak oxygen uptake (VO2-peak)) or a CT group (continuously 5×/week for 30 minutes/session at 65% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS at entry ( t0) and discharge ( t1). Furthermore, VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and -9 were measured.Compared to CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both groups. Secondary outcomes indicated significant improvements in VO2-peak and a significant reduction in MMP-2 in the HIT group only.HIT represents a promising strategy to improve verbal memory and physical fitness in persons with MS. Further research is needed to determine the impact of exercise on biomarkers in MS. |
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| 700 | 1 | _ | |a Bloch, Wilhelm |b 1 |
| 700 | 1 | _ | |a Schenk, Alexander |b 2 |
| 700 | 1 | _ | |a Oberste, Max |b 3 |
| 700 | 1 | _ | |a Riedel, Stefan |b 4 |
| 700 | 1 | _ | |a Kool, Jan |b 5 |
| 700 | 1 | _ | |a Langdon, Dawn |b 6 |
| 700 | 1 | _ | |a Dalgas, Ulrik |b 7 |
| 700 | 1 | _ | |a Kesselring, Jürg |b 8 |
| 700 | 1 | _ | |a Bansi, Jens |b 9 |
| 773 | _ | _ | |a 10.1177/1352458517728342 |g Vol. 24, no. 12, p. 1635 - 1644 |0 PERI:(DE-600)2008225-3 |n 12 |p 1635 - 1644 |t Multiple sclerosis journal |v 24 |y 2018 |x 1477-0970 |
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