%0 Journal Article
%A Campa, Daniele
%A Matarazzi, Martina
%A Greenhalf, William
%A Bijlsma, Maarten
%A Saum, Kai-Uwe
%A Pasquali, Claudio
%A van Laarhoven, Hanneke
%A Szentesi, Andrea
%A Federici, Francesca
%A Vodicka, Pavel
%A Funel, Niccola
%A Pezzilli, Raffaele
%A Bueno-de-Mesquita, H Bas
%A Vodickova, Ludmila
%A Basso, Daniela
%A Obazee, Ofure
%A Hackert, Thilo
%A Soucek, Pavel
%A Cuk, Katarina
%A Kaiser, Jörg
%A Sperti, Cosimo
%A Lovecek, Martin
%A Capurso, Gabriele
%A Mohelnikova-Duchonova, Beatrice
%A Khaw, Kay-Tee
%A König, Anna-Katharina
%A Kupcinskas, Juozas
%A Kaaks, Rudolf
%A Bambi, Franco
%A Archibugi, Livia
%A Mambrini, Andrea
%A Cavestro, Giulia Martina
%A Landi, Stefano
%A Hegyi, Péter
%A Izbicki, Jakob R
%A Gioffreda, Domenica
%A Zambon, Carlo Federico
%A Tavano, Francesca
%A Talar-Wojnarowska, Renata
%A Jamroziak, Krzysztof
%A Key, Timothy J
%A Fave, Gianfranco Delle
%A Strobel, Oliver
%A Jonaitis, Laimas
%A Andriulli, Angelo
%A Lawlor, Rita T
%A Pirozzi, Felice
%A Katzke, Verena
%A Valsuani, Chiara
%A Vashist, Yogesh K
%A Brenner, Hermann
%A Canzian, Federico
%T Genetic determinants of telomere length and risk of pancreatic cancer: a PANDoRA study.
%J International journal of cancer
%V 144
%N 6
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-01811
%P 1275-1283
%D 2019
%X Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. For pancreatic ductal adenocarcinoma (PDAC) consensus is lacking whether risk is associated with long or short telomeres. Mendelian randomization approaches have shown that a score built from SNPs associated with LTL could be used as a robust risk marker. We explored this approach in a large scale study within the PANcreatic Disease ReseArch (PANDoRA) consortium. We analyzed 10 SNPs (ZNF676-rs409627, TERT-rs2736100, CTC1-rs3027234, DHX35-rs6028466, PXK-rs6772228, NAF1-rs7675998, ZNF208-rs8105767, OBFC1-rs9420907, ACYP2-rs11125529 and TERC-rs10936599) alone and combined in a LTL genetic score ('teloscore', which explains 2.2
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30325019
%R 10.1002/ijc.31928
%U https://inrepo02.dkfz.de/record/141291