000141311 001__ 141311
000141311 005__ 20240229112523.0
000141311 0247_ $$2doi$$a10.1016/j.clon.2018.10.001
000141311 0247_ $$2pmid$$apmid:30389261
000141311 0247_ $$2ISSN$$a0936-6555
000141311 0247_ $$2ISSN$$a1433-2981
000141311 0247_ $$2ISSN$$a1433-2987
000141311 0247_ $$2altmetric$$aaltmetric:50521172
000141311 037__ $$aDKFZ-2018-01830
000141311 041__ $$aeng
000141311 082__ $$a610
000141311 1001_ $$aJohnson, K.$$b0
000141311 245__ $$aGenetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients.
000141311 260__ $$a[S.l.]$$bSaunders$$c2019
000141311 3367_ $$2DRIVER$$aarticle
000141311 3367_ $$2DataCite$$aOutput Types/Journal article
000141311 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1551180880_32589
000141311 3367_ $$2BibTeX$$aARTICLE
000141311 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000141311 3367_ $$00$$2EndNote$$aJournal Article
000141311 520__ $$aRadiotherapy is an important treatment for many types of cancer, but a minority of patients suffer long-term side-effects of treatment. Multiple lines of evidence suggest a role for circadian rhythm in the development of radiotherapy late side-effects.We carried out a study to examine the effect of radiotherapy timing in two breast cancer patient cohorts. The retrospective LeND cohort comprised 535 patients scored for late effects using the Late Effects of Normal Tissue-Subjective Objective Management Analytical (LENT-SOMA) scale. Acute effects were assessed prospectively in 343 patients from the REQUITE study using the CTCAE v4 scales. Genotyping was carried out for candidate circadian rhythm variants.In the LeND cohort, patients who had radiotherapy in the morning had a significantly increased incidence of late toxicity in univariate (P = 0.03) and multivariate analysis (P = 0.01). Acute effects in the REQUITE group were also significantly increased in univariate analysis after morning treatment (P = 0.03) but not on multivariate analysis. Increased late effects in the LeND group receiving morning radiotherapy were associated with carriage of the PER3 variable number tandem repeat 4/4 genotype (P = 6 × 10-3) and the NOCT rs131116075 AA genotype (P = 5 × 10-3).Our results suggest that it may be possible to reduce toxicity associated with breast cancer radiotherapy by identifying gene variants that affect circadian rhythm and scheduling for appropriate morning or afternoon radiotherapy.
000141311 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
000141311 588__ $$aDataset connected to CrossRef, PubMed,
000141311 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, J.$$b1$$udkfz
000141311 7001_ $$aCritchley, A-M$$b2
000141311 7001_ $$aKyriacou, C.$$b3
000141311 7001_ $$aLavers, S.$$b4
000141311 7001_ $$aRattay, T.$$b5
000141311 7001_ $$0P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aSeibold, P.$$b6$$udkfz
000141311 7001_ $$aWebb, A.$$b7
000141311 7001_ $$aWest, C.$$b8
000141311 7001_ $$aSymonds, R. P.$$b9
000141311 7001_ $$aTalbot, C. J.$$b10
000141311 7001_ $$aConsortium, REQUITE$$b11$$eCollaboration Author
000141311 7001_ $$aAzria, David$$b12
000141311 7001_ $$aBrookes, Anthony$$b13
000141311 7001_ $$aBurr, Tom$$b14
000141311 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b15$$udkfz
000141311 7001_ $$aDavidson, Susan$$b16
000141311 7001_ $$aDe Ruysscher, Dirk$$b17
000141311 7001_ $$aDunning, Alison$$b18
000141311 7001_ $$aElliott, Rebecca$$b19
000141311 7001_ $$aGutiérrez Enríquez, Sara$$b20
000141311 7001_ $$aLambin, Philippe$$b21
000141311 7001_ $$aRancati, Tiziana$$b22
000141311 7001_ $$aRosenstein, Barry$$b23
000141311 7001_ $$0P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aSeibold, Petra$$b24$$udkfz
000141311 7001_ $$aSymonds, R Paul$$b25
000141311 7001_ $$aTalbot, Chris$$b26
000141311 7001_ $$aThierens, Hubert$$b27
000141311 7001_ $$aValdagni, Riccardo$$b28
000141311 7001_ $$aVega, Ana$$b29
000141311 7001_ $$aVeldeman, Liv$$b30
000141311 7001_ $$aWenz, Frederik$$b31
000141311 7001_ $$aYuille, Martin$$b32
000141311 7001_ $$aWest, Catharine$$b33
000141311 773__ $$0PERI:(DE-600)1458892-4$$a10.1016/j.clon.2018.10.001$$gp. S093665551830462X$$n1$$p9-16$$tClinical oncology$$v31$$x0936-6555$$y2019
000141311 909CO $$ooai:inrepo02.dkfz.de:141311$$pVDB
000141311 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000141311 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bCLIN ONCOL-UK : 2017
000141311 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000141311 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000141311 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000141311 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000141311 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000141311 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000141311 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000141311 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine
000141311 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000141311 9141_ $$y2019
000141311 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000141311 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aDeutsches Krebsforschungszentrum$$b6$$kDKFZ
000141311 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b15$$kDKFZ
000141311 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)fd17a8dbf8d08ea5bb656dfef7398215$$aDeutsches Krebsforschungszentrum$$b24$$kDKFZ
000141311 9131_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000141311 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lEpidemiologie von Krebserkrankungen$$x0
000141311 980__ $$ajournal
000141311 980__ $$aVDB
000141311 980__ $$aI:(DE-He78)C020-20160331
000141311 980__ $$aUNRESTRICTED