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@ARTICLE{Johnson:141311,
      author       = {K. Johnson and J. Chang-Claude$^*$ and A.-M. Critchley and
                      C. Kyriacou and S. Lavers and T. Rattay and P. Seibold$^*$
                      and A. Webb and C. West and R. P. Symonds and C. J. Talbot
                      and D. Azria and A. Brookes and T. Burr and J.
                      Chang-Claude$^*$ and S. Davidson and D. De Ruysscher and A.
                      Dunning and R. Elliott and S. Gutiérrez Enríquez and P.
                      Lambin and T. Rancati and B. Rosenstein and P. Seibold$^*$
                      and R. P. Symonds and C. Talbot and H. Thierens and R.
                      Valdagni and A. Vega and L. Veldeman and F. Wenz and M.
                      Yuille and C. West},
      collaboration = {R. Consortium},
      title        = {{G}enetic {V}ariants {P}redict {O}ptimal {T}iming of
                      {R}adiotherapy to {R}educe {S}ide-effects in {B}reast
                      {C}ancer {P}atients.},
      journal      = {Clinical oncology},
      volume       = {31},
      number       = {1},
      issn         = {0936-6555},
      address      = {[S.l.]},
      publisher    = {Saunders},
      reportid     = {DKFZ-2018-01830},
      pages        = {9-16},
      year         = {2019},
      abstract     = {Radiotherapy is an important treatment for many types of
                      cancer, but a minority of patients suffer long-term
                      side-effects of treatment. Multiple lines of evidence
                      suggest a role for circadian rhythm in the development of
                      radiotherapy late side-effects.We carried out a study to
                      examine the effect of radiotherapy timing in two breast
                      cancer patient cohorts. The retrospective LeND cohort
                      comprised 535 patients scored for late effects using the
                      Late Effects of Normal Tissue-Subjective Objective
                      Management Analytical (LENT-SOMA) scale. Acute effects were
                      assessed prospectively in 343 patients from the REQUITE
                      study using the CTCAE v4 scales. Genotyping was carried out
                      for candidate circadian rhythm variants.In the LeND cohort,
                      patients who had radiotherapy in the morning had a
                      significantly increased incidence of late toxicity in
                      univariate (P = 0.03) and multivariate analysis
                      (P = 0.01). Acute effects in the REQUITE group were also
                      significantly increased in univariate analysis after morning
                      treatment (P = 0.03) but not on multivariate analysis.
                      Increased late effects in the LeND group receiving morning
                      radiotherapy were associated with carriage of the PER3
                      variable number tandem repeat 4/4 genotype
                      (P = 6 × 10-3) and the NOCT rs131116075 AA genotype
                      (P = 5 × 10-3).Our results suggest that it may be
                      possible to reduce toxicity associated with breast cancer
                      radiotherapy by identifying gene variants that affect
                      circadian rhythm and scheduling for appropriate morning or
                      afternoon radiotherapy.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30389261},
      doi          = {10.1016/j.clon.2018.10.001},
      url          = {https://inrepo02.dkfz.de/record/141311},
}