%0 Journal Article
%A Karimian-Jazi, Kianush
%A Wildemann, Brigitte
%A Diem, Ricarda
%A Schwarz, Daniel
%A Hielscher, Thomas
%A Wick, Wolfgang
%A Bendszus, Martin
%A Breckwoldt, Michael
%T Gd contrast administration is dispensable in patients with MS without new T2 lesions on follow-up MRI.
%J Neurology
%V 5
%N 5
%@ 2332-7812
%C Philadelphia, Pa.
%I Lippincott Williams & Wilkins
%M DKFZ-2018-01904
%P e480
%D 2018
%Z Neurology Neuroimmunology & Neuroinflammation
%X To assess the diagnostic value of gadolinium (Gd) contrast administration in MRI follow-up examinations of patients with MS if the T2 lesion load is stable.We included 100 patients with MS with at least 2 cranial MRI follow-up examinations (mean follow-up time 4.0 ± 2.6 years). MRI was performed at 3 Tesla with a standardized protocol including T2-weighted, fluid-attenuated inversion recovery (FLAIR) and T1-weighted contrast-enhanced sequences. Images were analyzed for T2/FLAIR and contrast-enhancing (CE) lesions by 3 independent neuroradiologists. Isolated Gd-enhancing lesions without correlate in T2 and FLAIR images, and reactivated Gd+ lesions were further assessed for size and signal intensity.We identified a total of 343 new T2 lesions and 152 CE lesions in a total of 559 MRI follow-up examinations. New T2/FLAIR lesions were present in 30
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30038948
%2 pmc:PMC6053940
%R 10.1212/NXI.0000000000000480
%U https://inrepo02.dkfz.de/record/141398