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@ARTICLE{Bochtler:141415,
      author       = {T. Bochtler$^*$ and M. Kartal-Kaess$^*$ and M. Granzow and
                      T. Hielscher$^*$ and M. R. Cosenza$^*$ and C. Herold-Mende
                      and A. Jauch and A. Krämer$^*$},
      title        = {{M}icronucleus formation in human cancer cells is biased by
                      chromosome size.},
      journal      = {Genes, chromosomes $\&$ cancer},
      volume       = {58},
      number       = {6},
      issn         = {1045-2257},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01921},
      pages        = {392-395},
      year         = {2019},
      abstract     = {Chromosomal instability is one of the hallmarks of cancer
                      and caused by chromosome missegregation during mitosis, a
                      process frequently associated with micronucleus formation.
                      Micronuclei are formed when chromosomes fail to join a
                      daughter nucleus during cell division and are surrounded by
                      their own nuclear membrane. Although it has been commonly
                      assumed that the gain or loss of specific chromosomes is
                      random during compromised cell division, recent data suggest
                      that the size of chromosomes can impact on chromosome
                      segregation fidelity. To test whether chromosome
                      missegregation rates scale with chromosome size in primary
                      human cancer cells, we assessed chromosome sequestration
                      into micronuclei in patient-derived primary NCH149
                      glioblastoma cells, which display high-level numerical
                      chromosome instability (CIN), pronounced spontaneous
                      micronucleus formation but virtually no structural CIN. The
                      cells were analysed by interphase
                      fluorescence-in-situ-hybridization (FISH) using
                      chromosome-specific painting probes for all chromosomes.
                      Overall, $33\%$ of early passage NCH149 cells harbored
                      micronuclei. Entrapment within a micronucleus clearly
                      correlated with chromosome size with larger chromosomes
                      being significantly more frequently missegregated into
                      micronuclei than smaller chromosomes in primary glioblastoma
                      cells. These findings extend the concept that chromosome
                      size determines segregation fidelity by implying that
                      size-specific micronucleus entrapment occurs in primary
                      human cancer cells as well. This article is protected by
                      copyright. All rights reserved.},
      cin          = {A360 / C060},
      ddc          = {610},
      cid          = {I:(DE-He78)A360-20160331 / I:(DE-He78)C060-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30411433},
      doi          = {10.1002/gcc.22707},
      url          = {https://inrepo02.dkfz.de/record/141415},
}