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000141416 1001_ $$aKesch, Claudia$$b0
000141416 245__ $$aCorrelation between genomic index lesions and mpMRI and 68Ga-PSMA-PET/CT imaging features in primary prostate cancer.
000141416 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2018
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000141416 520__ $$aMagnetic resonance imaging (MRI) and prostate specific membrane antigen (PSMA)- positron emission tomography (PET)/computed tomography (CT)-imaging of prostate cancer (PCa) are emerging techniques to assess the presence of significant disease and tumor progression. It is not known, however, whether and to what extent lesions detected by these imaging techniques correlate with genomic features of PCa. The aim of this study was therefore to define a genomic index lesion based on chromosomal copy number alterations (CNAs) as marker for tumor aggressiveness in prostate biopsies in direct correlation to multiparametric (mp) MRI and 68Ga-PSMA-PET/CT imaging features. CNA profiles of 46 biopsies from five consecutive patients with clinically high-risk PCa were obtained from radiologically suspicious and unsuspicious areas. All patients underwent mpMRI, MRI/TRUS-fusion biopsy, 68Ga-PSMA-PET/CT and a radical prostatectomy. CNAs were directly correlated to imaging features and radiogenomic analyses were performed. Highly significant CNAs (≥10 Mbp) were found in 22 of 46 biopsies. Chromosome 8p, 13q and 5q losses were the most common findings. There was an strong correspondence between the radiologic and the genomic index lesions. The radiogenomic analyses suggest the feasibility of developing radiologic signatures that can distinguish between genomically more or less aggressive lesions. In conclusion, imaging features of mpMRI and 68Ga-PSMA-PET/CT can guide to the genomically most aggressive lesion of a PCa. Radiogenomics may help to better differentiate between indolent and aggressive PCa in the future.
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000141416 7001_ $$aRadtke, Jan-Philipp$$b1
000141416 7001_ $$aWintsche, Axel$$b2
000141416 7001_ $$0P:(DE-He78)1042737c83ba70ec508bdd99f0096864$$aWiesenfarth, Manuel$$b3
000141416 7001_ $$aLuttje, Mariska$$b4
000141416 7001_ $$aGasch, Claudia$$b5
000141416 7001_ $$aDieffenbacher, Svenja$$b6
000141416 7001_ $$aPecqueux, Carine$$b7
000141416 7001_ $$aTeber, Dogu$$b8
000141416 7001_ $$aHatiboglu, Gencay$$b9
000141416 7001_ $$aNyarangi-Dix, Joanne$$b10
000141416 7001_ $$aSimpfendörfer, Tobias$$b11
000141416 7001_ $$aSchönberg, Gita$$b12
000141416 7001_ $$0P:(DE-He78)b2df3652dfa3e19d5e96dfc53f44a992$$aDimitrakopoulou-Strauss, Antonia$$b13
000141416 7001_ $$0P:(DE-He78)c420f6efccb409e1a287be027501a74c$$aFreitag, Martin$$b14
000141416 7001_ $$00000-0002-0168-4067$$aDuensing, Anette$$b15
000141416 7001_ $$aGrüllich, Carsten$$b16
000141416 7001_ $$aJäger, Dirk$$b17
000141416 7001_ $$0P:(DE-He78)abd768f879e71d08068d48fabb7e96cf$$aGötz, Michael$$b18
000141416 7001_ $$aGrabe, Niels$$b19
000141416 7001_ $$aSchweiger, Michal-Ruth$$b20
000141416 7001_ $$aPahernik, Sascha$$b21
000141416 7001_ $$aPerner, Sven$$b22
000141416 7001_ $$aHerpel, Esther$$b23
000141416 7001_ $$aRoth, Wilfried$$b24
000141416 7001_ $$aWieczorek, Kathrin$$b25
000141416 7001_ $$0P:(DE-He78)33c74005e1ce56f7025c4f6be15321b3$$aMaier-Hein, Klaus$$b26
000141416 7001_ $$aDebus, Jürgen$$b27
000141416 7001_ $$0P:(DE-He78)13a0afba029f5f64dc18b25ef7499558$$aHaberkorn, Uwe$$b28
000141416 7001_ $$0P:(DE-He78)5ca7e97b2769bb97f8c73431c6566b94$$aGiesel, Frederik$$b29
000141416 7001_ $$aGalle, Jörg$$b30
000141416 7001_ $$aHadaschik, Boris$$b31
000141416 7001_ $$0P:(DE-He78)3d04c8fee58c9ab71f62ff80d06b6fec$$aSchlemmer, Heinz-Peter$$b32
000141416 7001_ $$aHohenfellner, Markus$$b33
000141416 7001_ $$0P:(DE-He78)ea098e4d78abeb63afaf8c25ec6d6d93$$aBonekamp, David$$b34
000141416 7001_ $$0P:(DE-He78)7483734fd8ab316391aa604c95f0e98a$$aSültmann, Holger$$b35$$eLast author
000141416 7001_ $$aDuensing, Stefan$$b36
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