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@ARTICLE{Kesch:141416,
      author       = {C. Kesch and J.-P. Radtke and A. Wintsche and M.
                      Wiesenfarth$^*$ and M. Luttje and C. Gasch and S.
                      Dieffenbacher and C. Pecqueux and D. Teber and G. Hatiboglu
                      and J. Nyarangi-Dix and T. Simpfendörfer and G. Schönberg
                      and A. Dimitrakopoulou-Strauss$^*$ and M. Freitag$^*$ and A.
                      Duensing and C. Grüllich and D. Jäger and M. Götz$^*$ and
                      N. Grabe and M.-R. Schweiger and S. Pahernik and S. Perner
                      and E. Herpel and W. Roth and K. Wieczorek and K.
                      Maier-Hein$^*$ and J. Debus and U. Haberkorn$^*$ and F.
                      Giesel$^*$ and J. Galle and B. Hadaschik and H.-P.
                      Schlemmer$^*$ and M. Hohenfellner and D. Bonekamp$^*$ and H.
                      Sültmann$^*$ and S. Duensing},
      title        = {{C}orrelation between genomic index lesions and mp{MRI} and
                      68{G}a-{PSMA}-{PET}/{CT} imaging features in primary
                      prostate cancer.},
      journal      = {Scientific reports},
      volume       = {8},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2018-01922},
      pages        = {16708},
      year         = {2018},
      abstract     = {Magnetic resonance imaging (MRI) and prostate specific
                      membrane antigen (PSMA)- positron emission tomography
                      (PET)/computed tomography (CT)-imaging of prostate cancer
                      (PCa) are emerging techniques to assess the presence of
                      significant disease and tumor progression. It is not known,
                      however, whether and to what extent lesions detected by
                      these imaging techniques correlate with genomic features of
                      PCa. The aim of this study was therefore to define a genomic
                      index lesion based on chromosomal copy number alterations
                      (CNAs) as marker for tumor aggressiveness in prostate
                      biopsies in direct correlation to multiparametric (mp) MRI
                      and 68Ga-PSMA-PET/CT imaging features. CNA profiles of 46
                      biopsies from five consecutive patients with clinically
                      high-risk PCa were obtained from radiologically suspicious
                      and unsuspicious areas. All patients underwent mpMRI,
                      MRI/TRUS-fusion biopsy, 68Ga-PSMA-PET/CT and a radical
                      prostatectomy. CNAs were directly correlated to imaging
                      features and radiogenomic analyses were performed. Highly
                      significant CNAs (≥10 Mbp) were found in 22 of 46
                      biopsies. Chromosome 8p, 13q and 5q losses were the most
                      common findings. There was an strong correspondence between
                      the radiologic and the genomic index lesions. The
                      radiogenomic analyses suggest the feasibility of developing
                      radiologic signatures that can distinguish between
                      genomically more or less aggressive lesions. In conclusion,
                      imaging features of mpMRI and 68Ga-PSMA-PET/CT can guide to
                      the genomically most aggressive lesion of a PCa.
                      Radiogenomics may help to better differentiate between
                      indolent and aggressive PCa in the future.},
      cin          = {C060 / E060 / E010 / E132 / E230 / B063 / L101},
      ddc          = {600},
      cid          = {I:(DE-He78)C060-20160331 / I:(DE-He78)E060-20160331 /
                      I:(DE-He78)E010-20160331 / I:(DE-He78)E132-20160331 /
                      I:(DE-He78)E230-20160331 / I:(DE-He78)B063-20160331 /
                      I:(DE-He78)L101-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30420756},
      doi          = {10.1038/s41598-018-35058-3},
      url          = {https://inrepo02.dkfz.de/record/141416},
}