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000141419 1001_ $$00000-0003-4362-9784$$aKelemen, Linda E$$b0
000141419 245__ $$ars495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
000141419 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2018
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000141419 520__ $$aThymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.
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000141419 7001_ $$aEarp, Madalene$$b1
000141419 7001_ $$aFridley, Brooke L$$b2
000141419 7001_ $$aChenevix-Trench, Georgia$$b3
000141419 7001_ $$aGroup, Australian Ovarian Cancer Study$$b4$$eCollaboration Author
000141419 7001_ $$aFasching, Peter A$$b5
000141419 7001_ $$aBeckmann, Matthias W$$b6
000141419 7001_ $$aEkici, Arif B$$b7
000141419 7001_ $$00000-0003-2601-3398$$aHein, Alexander$$b8
000141419 7001_ $$aLambrechts, Diether$$b9
000141419 7001_ $$aLambrechts, Sandrina$$b10
000141419 7001_ $$aVan Nieuwenhuysen, Els$$b11
000141419 7001_ $$aVergote, Ignace$$b12
000141419 7001_ $$aRossing, Mary Anne$$b13
000141419 7001_ $$aDoherty, Jennifer A$$b14
000141419 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b15$$udkfz
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000141419 7001_ $$aMoysich, Kirsten B$$b17
000141419 7001_ $$aCannioto, Rikki$$b18
000141419 7001_ $$aLele, Shashikant$$b19
000141419 7001_ $$aOdunsi, Kunle$$b20
000141419 7001_ $$aGoodman, Marc T$$b21
000141419 7001_ $$aShvetsov, Yurii B$$b22
000141419 7001_ $$aThompson, Pamela J$$b23
000141419 7001_ $$aWilkens, Lynne R$$b24
000141419 7001_ $$aDörk, Thilo$$b25
000141419 7001_ $$aAntonenkova, Natalia$$b26
000141419 7001_ $$aBogdanova, Natalia$$b27
000141419 7001_ $$00000-0001-9829-3531$$aHillemanns, Peter$$b28
000141419 7001_ $$aRunnebaum, Ingo B$$b29
000141419 7001_ $$adu Bois, Andreas$$b30
000141419 7001_ $$aHarter, Philipp$$b31
000141419 7001_ $$aHeitz, Florian$$b32
000141419 7001_ $$aSchwaab, Ira$$b33
000141419 7001_ $$aButzow, Ralf$$b34
000141419 7001_ $$aPelttari, Liisa M$$b35
000141419 7001_ $$00000-0002-0916-2976$$aNevanlinna, Heli$$b36
000141419 7001_ $$aModugno, Francesmary$$b37
000141419 7001_ $$aEdwards, Robert P$$b38
000141419 7001_ $$aKelley, Joseph L$$b39
000141419 7001_ $$aNess, Roberta B$$b40
000141419 7001_ $$aKarlan, Beth Y$$b41
000141419 7001_ $$aLester, Jenny$$b42
000141419 7001_ $$aOrsulic, Sandra$$b43
000141419 7001_ $$aWalsh, Christine$$b44
000141419 7001_ $$00000-0002-8347-1398$$aKjaer, Susanne K$$b45
000141419 7001_ $$00000-0001-8124-4880$$aJensen, Allan$$b46
000141419 7001_ $$00000-0002-8159-3025$$aCunningham, Julie M$$b47
000141419 7001_ $$00000-0001-6242-5221$$aVierkant, Robert A$$b48
000141419 7001_ $$aGiles, Graham G$$b49
000141419 7001_ $$aBruinsma, Fiona$$b50
000141419 7001_ $$aSouthey, Melissa C$$b51
000141419 7001_ $$aHildebrandt, Michelle A T$$b52
000141419 7001_ $$aLiang, Dong$$b53
000141419 7001_ $$aLu, Karen$$b54
000141419 7001_ $$aWu, Xifeng$$b55
000141419 7001_ $$aSellers, Thomas A$$b56
000141419 7001_ $$aLevine, Douglas A$$b57
000141419 7001_ $$aSchildkraut, Joellen M$$b58
000141419 7001_ $$aIversen, Edwin S$$b59
000141419 7001_ $$aTerry, Kathryn L$$b60
000141419 7001_ $$aCramer, Daniel W$$b61
000141419 7001_ $$aTworoger, Shelley S$$b62
000141419 7001_ $$aPoole, Elizabeth M$$b63
000141419 7001_ $$aBandera, Elisa V$$b64
000141419 7001_ $$aOlson, Sara H$$b65
000141419 7001_ $$aOrlow, Irene$$b66
000141419 7001_ $$aVestrheim Thomsen, Liv Cecilie$$b67
000141419 7001_ $$00000-0002-0240-2770$$aBjorge, Line$$b68
000141419 7001_ $$aKrakstad, Camilla$$b69
000141419 7001_ $$aTangen, Ingvild L$$b70
000141419 7001_ $$aKiemeney, Lambertus A$$b71
000141419 7001_ $$aAben, Katja K H$$b72
000141419 7001_ $$aMassuger, Leon F A G$$b73
000141419 7001_ $$avan Altena, Anne M$$b74
000141419 7001_ $$aPejovic, Tanja$$b75
000141419 7001_ $$aBean, Yukie$$b76
000141419 7001_ $$aKellar, Melissa$$b77
000141419 7001_ $$aCook, Linda S$$b78
000141419 7001_ $$aLe, Nhu D$$b79
000141419 7001_ $$aBrooks-Wilson, Angela$$b80
000141419 7001_ $$00000-0002-3643-2871$$aGronwald, Jacek$$b81
000141419 7001_ $$aCybulski, Cezary$$b82
000141419 7001_ $$aJakubowska, Anna$$b83
000141419 7001_ $$aLubiński, Jan$$b84
000141419 7001_ $$aWentzensen, Nicolas$$b85
000141419 7001_ $$00000-0003-3853-8562$$aBrinton, Louise A$$b86
000141419 7001_ $$aLissowska, Jolanta$$b87
000141419 7001_ $$aHogdall, Estrid$$b88
000141419 7001_ $$aEngelholm, Svend Aage$$b89
000141419 7001_ $$aHogdall, Claus$$b90
000141419 7001_ $$aLundvall, Lene$$b91
000141419 7001_ $$aNedergaard, Lotte$$b92
000141419 7001_ $$00000-0001-8494-732X$$aPharoah, Paul D P$$b93
000141419 7001_ $$aDicks, Ed$$b94
000141419 7001_ $$aSong, Honglin$$b95
000141419 7001_ $$00000-0003-3724-4757$$aTyrer, Jonathan P$$b96
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000141419 7001_ $$aCampbell, Ian G$$b102
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000141419 7001_ $$aWhittemore, Alice S$$b104
000141419 7001_ $$aMcGuire, Valerie$$b105
000141419 7001_ $$aRothstein, Joseph H$$b106
000141419 7001_ $$aSieh, Weiva$$b107
000141419 7001_ $$aNarod, Steven A$$b108
000141419 7001_ $$aPhelan, Catherine M$$b109
000141419 7001_ $$aMcLaughlin, John R$$b110
000141419 7001_ $$aRisch, Harvey A$$b111
000141419 7001_ $$aAnton-Culver, Hoda$$b112
000141419 7001_ $$aZiogas, Argyrios$$b113
000141419 7001_ $$00000-0003-3708-1732$$aMenon, Usha$$b114
000141419 7001_ $$aGayther, Simon A$$b115
000141419 7001_ $$aGentry-Maharaj, Aleksandra$$b116
000141419 7001_ $$00000-0003-0005-7798$$aRamus, Susan J$$b117
000141419 7001_ $$aWu, Anna H$$b118
000141419 7001_ $$aPearce, Celeste Leigh$$b119
000141419 7001_ $$aLee, Alice W$$b120
000141419 7001_ $$aPike, Malcolm C$$b121
000141419 7001_ $$aKupryjanczyk, Jolanta$$b122
000141419 7001_ $$aPodgorska, Agnieszka$$b123
000141419 7001_ $$aPlisiecka-Halasa, Joanna$$b124
000141419 7001_ $$aSawicki, Wlodzimierz$$b125
000141419 7001_ $$aGoode, Ellen L$$b126
000141419 7001_ $$aBerchuck, Andrew$$b127
000141419 7001_ $$aConsortium, Ovarian Cancer Association$$b128$$eCollaboration Author
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