Home > Publications database > rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology. > print

001     141419
005     20240229105127.0
024 7 _ |a 10.3390/ijms19092473
|2 doi
024 7 _ |a pmid:30134598
|2 pmid
024 7 _ |a pmc:PMC6163881
|2 pmc
024 7 _ |a 1422-0067
|2 ISSN
024 7 _ |a 1661-6596
|2 ISSN
024 7 _ |a altmetric:46923305
|2 altmetric
037 _ _ |a DKFZ-2018-01925
041 _ _ |a eng
082 _ _ |a 540
100 1 _ |a Kelemen, Linda E
|0 0000-0003-4362-9784
|b 0
245 _ _ |a rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.
260 _ _ |a Basel
|c 2018
|b Molecular Diversity Preservation International
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1542808079_19439
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a Thymidylate synthase (TYMS) is a crucial enzyme for DNA synthesis. TYMS expression is regulated by its antisense mRNA, ENOSF1. Disrupted regulation may promote uncontrolled DNA synthesis and tumor growth. We sought to replicate our previously reported association between rs495139 in the TYMS-ENOSF1 3' gene region and increased risk of mucinous ovarian carcinoma (MOC) in an independent sample. Genotypes from 24,351 controls to 15,000 women with invasive OC, including 665 MOC, were available. We estimated per-allele odds ratios (OR) and 95% confidence intervals (CI) using unconditional logistic regression, and meta-analysis when combining these data with our previous report. The association between rs495139 and MOC was not significant in the independent sample (OR = 1.09; 95% CI = 0.97⁻1.22; p = 0.15; N = 665 cases). Meta-analysis suggested a weak association (OR = 1.13; 95% CI = 1.03⁻1.24; p = 0.01; N = 1019 cases). No significant association with risk of other OC histologic types was observed (p = 0.05 for tumor heterogeneity). In expression quantitative trait locus (eQTL) analysis, the rs495139 allele was positively associated with ENOSF1 mRNA expression in normal tissues of the gastrointestinal system, particularly esophageal mucosa (r = 0.51, p = 1.7 × 10-28), and nonsignificantly in five MOC tumors. The association results, along with inconclusive tumor eQTL findings, suggest that a true effect of rs495139 might be small.
536 _ _ |a 313 - Cancer risk factors and prevention (POF3-313)
|0 G:(DE-HGF)POF3-313
|c POF3-313
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed,
700 1 _ |a Earp, Madalene
|b 1
700 1 _ |a Fridley, Brooke L
|b 2
700 1 _ |a Chenevix-Trench, Georgia
|b 3
700 1 _ |a Group, Australian Ovarian Cancer Study
|b 4
|e Collaboration Author
700 1 _ |a Fasching, Peter A
|b 5
700 1 _ |a Beckmann, Matthias W
|b 6
700 1 _ |a Ekici, Arif B
|b 7
700 1 _ |a Hein, Alexander
|0 0000-0003-2601-3398
|b 8
700 1 _ |a Lambrechts, Diether
|b 9
700 1 _ |a Lambrechts, Sandrina
|b 10
700 1 _ |a Van Nieuwenhuysen, Els
|b 11
700 1 _ |a Vergote, Ignace
|b 12
700 1 _ |a Rossing, Mary Anne
|b 13
700 1 _ |a Doherty, Jennifer A
|b 14
700 1 _ |a Chang-Claude, Jenny
|0 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
|b 15
|u dkfz
700 1 _ |a Behrens, Sabine
|0 P:(DE-He78)6b04712f3afe72044d496a25505cb1ea
|b 16
|u dkfz
700 1 _ |a Moysich, Kirsten B
|b 17
700 1 _ |a Cannioto, Rikki
|b 18
700 1 _ |a Lele, Shashikant
|b 19
700 1 _ |a Odunsi, Kunle
|b 20
700 1 _ |a Goodman, Marc T
|b 21
700 1 _ |a Shvetsov, Yurii B
|b 22
700 1 _ |a Thompson, Pamela J
|b 23
700 1 _ |a Wilkens, Lynne R
|b 24
700 1 _ |a Dörk, Thilo
|b 25
700 1 _ |a Antonenkova, Natalia
|b 26
700 1 _ |a Bogdanova, Natalia
|b 27
700 1 _ |a Hillemanns, Peter
|0 0000-0001-9829-3531
|b 28
700 1 _ |a Runnebaum, Ingo B
|b 29
700 1 _ |a du Bois, Andreas
|b 30
700 1 _ |a Harter, Philipp
|b 31
700 1 _ |a Heitz, Florian
|b 32
700 1 _ |a Schwaab, Ira
|b 33
700 1 _ |a Butzow, Ralf
|b 34
700 1 _ |a Pelttari, Liisa M
|b 35
700 1 _ |a Nevanlinna, Heli
|0 0000-0002-0916-2976
|b 36
700 1 _ |a Modugno, Francesmary
|b 37
700 1 _ |a Edwards, Robert P
|b 38
700 1 _ |a Kelley, Joseph L
|b 39
700 1 _ |a Ness, Roberta B
|b 40
700 1 _ |a Karlan, Beth Y
|b 41
700 1 _ |a Lester, Jenny
|b 42
700 1 _ |a Orsulic, Sandra
|b 43
700 1 _ |a Walsh, Christine
|b 44
700 1 _ |a Kjaer, Susanne K
|0 0000-0002-8347-1398
|b 45
700 1 _ |a Jensen, Allan
|0 0000-0001-8124-4880
|b 46
700 1 _ |a Cunningham, Julie M
|0 0000-0002-8159-3025
|b 47
700 1 _ |a Vierkant, Robert A
|0 0000-0001-6242-5221
|b 48
700 1 _ |a Giles, Graham G
|b 49
700 1 _ |a Bruinsma, Fiona
|b 50
700 1 _ |a Southey, Melissa C
|b 51
700 1 _ |a Hildebrandt, Michelle A T
|b 52
700 1 _ |a Liang, Dong
|b 53
700 1 _ |a Lu, Karen
|b 54
700 1 _ |a Wu, Xifeng
|b 55
700 1 _ |a Sellers, Thomas A
|b 56
700 1 _ |a Levine, Douglas A
|b 57
700 1 _ |a Schildkraut, Joellen M
|b 58
700 1 _ |a Iversen, Edwin S
|b 59
700 1 _ |a Terry, Kathryn L
|b 60
700 1 _ |a Cramer, Daniel W
|b 61
700 1 _ |a Tworoger, Shelley S
|b 62
700 1 _ |a Poole, Elizabeth M
|b 63
700 1 _ |a Bandera, Elisa V
|b 64
700 1 _ |a Olson, Sara H
|b 65
700 1 _ |a Orlow, Irene
|b 66
700 1 _ |a Vestrheim Thomsen, Liv Cecilie
|b 67
700 1 _ |a Bjorge, Line
|0 0000-0002-0240-2770
|b 68
700 1 _ |a Krakstad, Camilla
|b 69
700 1 _ |a Tangen, Ingvild L
|b 70
700 1 _ |a Kiemeney, Lambertus A
|b 71
700 1 _ |a Aben, Katja K H
|b 72
700 1 _ |a Massuger, Leon F A G
|b 73
700 1 _ |a van Altena, Anne M
|b 74
700 1 _ |a Pejovic, Tanja
|b 75
700 1 _ |a Bean, Yukie
|b 76
700 1 _ |a Kellar, Melissa
|b 77
700 1 _ |a Cook, Linda S
|b 78
700 1 _ |a Le, Nhu D
|b 79
700 1 _ |a Brooks-Wilson, Angela
|b 80
700 1 _ |a Gronwald, Jacek
|0 0000-0002-3643-2871
|b 81
700 1 _ |a Cybulski, Cezary
|b 82
700 1 _ |a Jakubowska, Anna
|b 83
700 1 _ |a Lubiński, Jan
|b 84
700 1 _ |a Wentzensen, Nicolas
|b 85
700 1 _ |a Brinton, Louise A
|0 0000-0003-3853-8562
|b 86
700 1 _ |a Lissowska, Jolanta
|b 87
700 1 _ |a Hogdall, Estrid
|b 88
700 1 _ |a Engelholm, Svend Aage
|b 89
700 1 _ |a Hogdall, Claus
|b 90
700 1 _ |a Lundvall, Lene
|b 91
700 1 _ |a Nedergaard, Lotte
|b 92
700 1 _ |a Pharoah, Paul D P
|0 0000-0001-8494-732X
|b 93
700 1 _ |a Dicks, Ed
|b 94
700 1 _ |a Song, Honglin
|b 95
700 1 _ |a Tyrer, Jonathan P
|0 0000-0003-3724-4757
|b 96
700 1 _ |a McNeish, Iain
|0 0000-0002-9387-7586
|b 97
700 1 _ |a Siddiqui, Nadeem
|b 98
700 1 _ |a Carty, Karen
|b 99
700 1 _ |a Glasspool, Rosalind
|b 100
700 1 _ |a Paul, James
|b 101
700 1 _ |a Campbell, Ian G
|b 102
700 1 _ |a Eccles, Diana
|0 0000-0002-9935-3169
|b 103
700 1 _ |a Whittemore, Alice S
|b 104
700 1 _ |a McGuire, Valerie
|b 105
700 1 _ |a Rothstein, Joseph H
|b 106
700 1 _ |a Sieh, Weiva
|b 107
700 1 _ |a Narod, Steven A
|b 108
700 1 _ |a Phelan, Catherine M
|b 109
700 1 _ |a McLaughlin, John R
|b 110
700 1 _ |a Risch, Harvey A
|b 111
700 1 _ |a Anton-Culver, Hoda
|b 112
700 1 _ |a Ziogas, Argyrios
|b 113
700 1 _ |a Menon, Usha
|0 0000-0003-3708-1732
|b 114
700 1 _ |a Gayther, Simon A
|b 115
700 1 _ |a Gentry-Maharaj, Aleksandra
|b 116
700 1 _ |a Ramus, Susan J
|0 0000-0003-0005-7798
|b 117
700 1 _ |a Wu, Anna H
|b 118
700 1 _ |a Pearce, Celeste Leigh
|b 119
700 1 _ |a Lee, Alice W
|b 120
700 1 _ |a Pike, Malcolm C
|b 121
700 1 _ |a Kupryjanczyk, Jolanta
|b 122
700 1 _ |a Podgorska, Agnieszka
|b 123
700 1 _ |a Plisiecka-Halasa, Joanna
|b 124
700 1 _ |a Sawicki, Wlodzimierz
|b 125
700 1 _ |a Goode, Ellen L
|b 126
700 1 _ |a Berchuck, Andrew
|b 127
700 1 _ |a Consortium, Ovarian Cancer Association
|b 128
|e Collaboration Author
773 _ _ |a 10.3390/ijms19092473
|g Vol. 19, no. 9, p. 2473 -
|0 PERI:(DE-600)2019364-6
|n 9
|p E2473
|t International journal of molecular sciences
|v 19
|y 2018
|x 1422-0067
909 C O |o oai:inrepo02.dkfz.de:141419
|p VDB
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 15
|6 P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 16
|6 P:(DE-He78)6b04712f3afe72044d496a25505cb1ea
913 1 _ |a DE-HGF
|l Krebsforschung
|1 G:(DE-HGF)POF3-310
|0 G:(DE-HGF)POF3-313
|2 G:(DE-HGF)POF3-300
|v Cancer risk factors and prevention
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
|b Gesundheit
914 1 _ |y 2018
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Blind peer review
915 _ _ |a Creative Commons Attribution CC BY (No Version)
|0 LIC:(DE-HGF)CCBYNV
|2 V:(DE-HGF)
|b DOAJ
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b INT J MOL SCI : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
920 1 _ |0 I:(DE-He78)C020-20160331
|k C020
|l Epidemiologie von Krebserkrankungen
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)C020-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21