%0 Journal Article
%A Graf, Mirja
%A Sookthai, Disorn
%A Johnson, Theron Scot
%A Schübel, Ruth
%A Maldonado, Sandra González
%A Pletsch-Borba, Laura
%A Katzke, Verena
%A Bugert, Peter
%A Hoffmeister, Michael
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Pre-diagnostic plasma concentrations of Fibrinogen, sGPIIb/IIIa, sP-selectin, sThrombomodulin, Thrombopoietin in relation to cancer risk: Findings from a large prospective study.
%J International journal of cancer
%V 143
%N 11
%@ 0020-7136
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2018-01927
%P 2659 - 2667
%D 2018
%X While enhanced platelet activation may drive cancer progression and metastases, less is known about its role in early cancer development. Thus, we evaluated whether pre-diagnostic biomarkers of platelet activation and coagulation are related to the risks of common cancers in the prospective EPIC-Heidelberg Study using a case-cohort design. Levels of fibrinogen, soluble glycoprotein (sGP) IIb/IIIa, soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM), and thrombopoietin (TPO) were measured in baseline plasma samples of a random subcohort (n = 2,480) and incident cases of breast (n = 605), prostate (n = 543), and colorectal cancer (n = 249). Multivariable Cox regression models revealed no statistically significant associations between biomarker concentrations and any of the cancer endpoints. Subgroup analyses showed a significant inverse relationship between TPO and colorectal cancer among men, with a hazard ratio (HR, highest vs. lowest quartile) of 0.60 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29923180
%R 10.1002/ijc.31623
%U https://inrepo02.dkfz.de/record/141421