TY  - JOUR
AU  - Graf, Mirja
AU  - Sookthai, Disorn
AU  - Johnson, Theron Scot
AU  - Schübel, Ruth
AU  - Maldonado, Sandra González
AU  - Pletsch-Borba, Laura
AU  - Katzke, Verena
AU  - Bugert, Peter
AU  - Hoffmeister, Michael
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Pre-diagnostic plasma concentrations of Fibrinogen, sGPIIb/IIIa, sP-selectin, sThrombomodulin, Thrombopoietin in relation to cancer risk: Findings from a large prospective study.
JO  - International journal of cancer
VL  - 143
IS  - 11
SN  - 0020-7136
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2018-01927
SP  - 2659 - 2667
PY  - 2018
AB  - While enhanced platelet activation may drive cancer progression and metastases, less is known about its role in early cancer development. Thus, we evaluated whether pre-diagnostic biomarkers of platelet activation and coagulation are related to the risks of common cancers in the prospective EPIC-Heidelberg Study using a case-cohort design. Levels of fibrinogen, soluble glycoprotein (sGP) IIb/IIIa, soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM), and thrombopoietin (TPO) were measured in baseline plasma samples of a random subcohort (n = 2,480) and incident cases of breast (n = 605), prostate (n = 543), and colorectal cancer (n = 249). Multivariable Cox regression models revealed no statistically significant associations between biomarker concentrations and any of the cancer endpoints. Subgroup analyses showed a significant inverse relationship between TPO and colorectal cancer among men, with a hazard ratio (HR, highest vs. lowest quartile) of 0.60 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:29923180
DO  - DOI:10.1002/ijc.31623
UR  - https://inrepo02.dkfz.de/record/141421
ER  -