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@ARTICLE{Graf:141421,
      author       = {M. Graf$^*$ and D. Sookthai$^*$ and T. S. Johnson$^*$ and
                      R. Schübel$^*$ and S. G. Maldonado$^*$ and L.
                      Pletsch-Borba$^*$ and V. Katzke$^*$ and P. Bugert and M.
                      Hoffmeister$^*$ and R. Kaaks$^*$ and T. Kühn$^*$},
      title        = {{P}re-diagnostic plasma concentrations of {F}ibrinogen,
                      s{GPII}b/{III}a, s{P}-selectin, s{T}hrombomodulin,
                      {T}hrombopoietin in relation to cancer risk: {F}indings from
                      a large prospective study.},
      journal      = {International journal of cancer},
      volume       = {143},
      number       = {11},
      issn         = {0020-7136},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2018-01927},
      pages        = {2659 - 2667},
      year         = {2018},
      abstract     = {While enhanced platelet activation may drive cancer
                      progression and metastases, less is known about its role in
                      early cancer development. Thus, we evaluated whether
                      pre-diagnostic biomarkers of platelet activation and
                      coagulation are related to the risks of common cancers in
                      the prospective EPIC-Heidelberg Study using a case-cohort
                      design. Levels of fibrinogen, soluble glycoprotein (sGP)
                      IIb/IIIa, soluble P-selectin (sP-selectin), soluble
                      thrombomodulin (sTM), and thrombopoietin (TPO) were measured
                      in baseline plasma samples of a random subcohort (n = 2,480)
                      and incident cases of breast (n = 605), prostate (n = 543),
                      and colorectal cancer (n = 249). Multivariable Cox
                      regression models revealed no statistically significant
                      associations between biomarker concentrations and any of the
                      cancer endpoints. Subgroup analyses showed a significant
                      inverse relationship between TPO and colorectal cancer among
                      men, with a hazard ratio (HR, highest vs. lowest quartile)
                      of 0.60 $(95\%$ confidence interval: 0.37,0.95), whereas no
                      significant association was observed among women. With
                      regard to fibrinogen levels and breast cancer risk, there
                      was a significant positive association among nulliparous
                      women (HR: 2.53 $[95\%$ CI: 1.21, 5.30]), but not among
                      parous women. Overall, our data suggest that enhanced
                      platelet activation and a pro-coagulative state may not be
                      related to increased risks of common cancers, although
                      studies on other potential biomarkers of platelet activation
                      and further cancer types are needed. Findings from our
                      subgroup analyses require further investigation, as
                      potential underlying mechanisms are not known.},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29923180},
      doi          = {10.1002/ijc.31623},
      url          = {https://inrepo02.dkfz.de/record/141421},
}