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@ARTICLE{Zheng:141422,
      author       = {J.-S. Zheng and F. Imamura and S. J. Sharp and Y. T. van
                      der Schouw and I. Sluijs and T. E. Gundersen and E. Ardanaz
                      and H. Boeing and C. Bonet and J. H. Gómez and C. Dow and
                      G. Fagherazzi and P. W. Franks and M. Jenab and T. Kühn$^*$
                      and R. Kaaks$^*$ and T. J. Key and K.-T. Khaw and C.
                      Lasheras and O. Mokoroa and F. R. Mancini and P. M. Nilsson
                      and K. Overvad and S. Panico and D. Palli and O. Rolandsson
                      and S. Sieri and E. Salamanca-Fernández and C. Sacerdote
                      and A. M. Spijkerman and M. Stepien and A. Tjonneland and R.
                      Tumino and A. S. Butterworth and E. Riboli and J. Danesh and
                      C. Langenberg and N. G. Forouhi and N. J. Wareham},
      title        = {{A}ssociation of plasma vitamin {D} metabolites with
                      incident type 2 diabetes: {EPIC}-{I}nter{A}ct case-cohort
                      study.},
      journal      = {The journal of clinical endocrinology $\&$ metabolism},
      volume       = {104},
      number       = {4},
      issn         = {1945-7197},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2018-01928},
      pages        = {1293-1303},
      year         = {2019},
      abstract     = {Existing evidence for the prospective association of
                      vitamin D status with type 2 diabetes (T2D) is focused
                      almost exclusively on circulating total 25-hydroxyvitamin D
                      [25(OH)D] without distinction between its subtypes:
                      non-epimeric and epimeric 25(OH)D3 stereoisomers; and
                      25(OH)D2, the minor component of 25(OH)D. We aimed to
                      investigate the prospective associations of circulating
                      levels of the sum and each of these three metabolites with
                      incident T2D.This analysis in the EPIC-InterAct case-cohort
                      study for T2D included 9671 incident T2D cases and 13562
                      subcohort members. Plasma vitamin D metabolites were
                      quantified by liquid-chromatography mass-spectrometry. We
                      used multivariable Prentice-weighted Cox regression to
                      estimate hazard ratios (HRs) of T2D for each metabolite.
                      Analyses were performed separately within country, and
                      estimates combined across countries using random-effects
                      meta-analysis.The mean concentrations (standard deviation)
                      of total 25(OH)D, non-epimeric 25(OH)D3, epimeric 25(OH)D3
                      and 25(OH)D2 were 41.1 (17.2), 40.7 (17.3), 2.13 (1.31), and
                      8.16 (6.52) nmol/L, respectively. Plasma total 25(OH)D and
                      non-epimeric 25(OH)D3 were inversely associated with
                      incident T2D [multivariable-adjusted HR per 1-SD=0.81
                      $(95\%CI:$ 0.77, 0.86) for both variables], while epimeric
                      25(OH)D3 was positively associated: per 1-SD HR=1.16 (1.09,
                      1.25). There was no statistically significant association
                      with T2D for 25(OH)D2 [per 1-SD HR=0.94 (0.76, 1.18)].Plasma
                      non-epimeric 25(OH)D3 was inversely associated with incident
                      T2D, consistent with it being the major metabolite
                      contributing to total 25(OH)D. The positive association of
                      the epimeric form of 25(OH)D3 with incident T2D provides
                      novel information to assess the biological relevance of
                      vitamin D epimerization and vitamin D subtypes in diabetes
                      etiology.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30418614},
      doi          = {10.1210/jc.2018-01522},
      url          = {https://inrepo02.dkfz.de/record/141422},
}