%0 Journal Article
%A Matejcic, Marco
%A Saunders, Edward J
%A Dadaev, Tokhir
%A Brook, Mark N
%A Wang, Kan
%A Sheng, Xin
%A Olama, Ali Amin Al
%A Schumacher, Fredrick R
%A Ingles, Sue A
%A Govindasami, Koveela
%A Benlloch, Sara
%A Berndt, Sonja I
%A Albanes, Demetrius
%A Koutros, Stella
%A Muir, Kenneth
%A Stevens, Victoria L
%A Gapstur, Susan M
%A Tangen, Catherine M
%A Batra, Jyotsna
%A Clements, Judith
%A Gronberg, Henrik
%A Pashayan, Nora
%A Schleutker, Johanna
%A Wolk, Alicja
%A West, Catharine
%A Mucci, Lorelei
%A Kraft, Peter
%A Cancel-Tassin, Géraldine
%A Sorensen, Karina D
%A Maehle, Lovise
%A Grindedal, Eli M
%A Strom, Sara S
%A Neal, David E
%A Hamdy, Freddie C
%A Donovan, Jenny L
%A Travis, Ruth C
%A Hamilton, Robert J
%A Rosenstein, Barry
%A Lu, Yong-Jie
%A Giles, Graham G
%A Kibel, Adam S
%A Vega, Ana
%A Bensen, Jeanette T
%A Kogevinas, Manolis
%A Penney, Kathryn L
%A Park, Jong Y
%A Stanford, Janet L
%A Cybulski, Cezary
%A Nordestgaard, Børge G
%A Brenner, Hermann
%A Maier, Christiane
%A Kim, Jeri
%A Teixeira, Manuel R
%A Neuhausen, Susan L
%A De Ruyck, Kim
%A Razack, Azad
%A Newcomb, Lisa F
%A Lessel, Davor
%A Kaneva, Radka
%A Usmani, Nawaid
%A Claessens, Frank
%A Townsend, Paul A
%A Dominguez, Manuela G
%A Roobol, Monique J
%A Menegaux, Florence
%A Khaw, Kay-Tee
%A Cannon-Albright, Lisa A
%A Pandha, Hardev
%A Thibodeau, Stephen N
%A Schaid, Daniel J
%A Wiklund, Fredrik
%A Chanock, Stephen J
%A Easton, Douglas F
%A Eeles, Rosalind A
%A Kote-Jarai, Zsofia
%A Conti, David V
%A Haiman, Christopher A
%A Henderson, Brian E
%A Stern, Mariana C
%A Thwaites, Alison
%A Guy, Michelle
%A Whitmore, Ian
%A Morgan, Angela
%A Fisher, Cyril
%A Hazel, Steve
%A Livni, Naomi
%A Cook, Margaret
%A Fachal, Laura
%A Weinstein, Stephanie
%A Beane Freeman, Laura E
%A Hoover, Robert N
%A Machiela, Mitchell J
%A Lophatananon, Artitaya
%A Carter, Brian D
%A Goodman, Phyllis
%A Moya, Leire
%A Srinivasan, Srilakshmi
%A Kedda, Mary-Anne
%A Yeadon, Trina
%A Eckert, Allison
%A Eklund, Martin
%A Cavalli-Bjoerkman, Carin
%A Dunning, Alison M
%A Sipeky, Csilla
%A Hakansson, Niclas
%A Elliott, Rebecca
%A Ranu, Hardeep
%A Giovannucci, Edward
%A Turman, Constance
%A Hunter, David J
%A Cussenot, Olivier
%A Orntoft, Torben Falck
%A Lane, Athene
%A Lewis, Sarah J
%A Davis, Michael
%A Key, Tim J
%A Brown, Paul
%A Kulkarni, Girish S
%A Zlotta, Alexandre R
%A Fleshner, Neil E
%A Finelli, Antonio
%A Mao, Xueying
%A Marzec, Jacek
%A MacInnis, Robert J
%A Milne, Roger
%A Hopper, John L
%A Aguado, Miguel
%A Bustamante, Mariona
%A Castaño-Vinyals, Gemma
%A Gracia-Lavedan, Esther
%A Cecchini, Lluís
%A Stampfer, Meir
%A Ma, Jing
%A Sellers, Thomas A
%A Geybels, Milan S
%A Park, Hyun
%A Zachariah, Babu
%A Kolb, Suzanne
%A Wokolorczyk, Dominika
%A Jan Lubinski
%A Kluzniak, Wojciech
%A Nielsen, Sune F
%A Weisher, Maren
%A Cuk, Katarina
%A Vogel, Walther
%A Luedeke, Manuel
%A Logothetis, Christopher J
%A Paulo, Paula
%A Cardoso, Marta
%A Maia, Sofia
%A Silva, Maria P
%A Steele, Linda
%A Ding, Yuan Chun
%A De Meerleer, Gert
%A De Langhe, Sofie
%A Thierens, Hubert
%A Lim, Jasmine
%A Tan, Meng H
%A Ong, Aik T
%A Lin, Daniel W
%A Kachakova, Darina
%A Mitkova, Atanaska
%A Mitev, Vanio
%A Parliament, Matthew
%A Jenster, Guido
%A Bangma, Christopher
%A Schroder, F. H.
%A Truong, Thérèse
%A Koudou, Yves Akoli
%A Michael, Agnieszka
%A Kierzek, Andrzej
%A Karlsson, Ami
%A Broms, Michael
%A Wu, Huihai
%A Aukim-Hastie, Claire
%A Tillmans, Lori
%A Riska, Shaun
%A McDonnell, Shannon K
%A Dearnaley, David
%A Spurdle, Amanda
%A Gardiner, Robert
%A Hayes, Vanessa
%A Butler, Lisa
%A Taylor, Renea
%A Papargiris, Melissa
%A Saunders, Pamela
%A Kujala, Paula
%A Talala, Kirsi
%A Taari, Kimmo
%A Bentzen, Søren
%A Hicks, Belynda
%A Vogt, Aurelie
%A Hutchinson, Amy
%A Cox, Angela
%A George, Anne
%A Toi, Ants
%A Evans, Andrew
%A van der Kwast, Theodorus H
%A Imai, Takashi
%A Saito, Shiro
%A Zhao, Shan-Chao
%A Ren, Guoping
%A Zhang, Yangling
%A Yu, Yongwei
%A Wu, Yudong
%A Wu, Ji
%A Zhou, Bo
%A Pedersen, John
%A Lobato-Busto, Ramón
%A Ruiz-Dominguez, José Manuel
%A Mengual, Lourdes
%A Alcaraz, Antonio
%A Pow-Sang, Julio
%A Herkommer, Kathleen
%A Vlahova, Aleksandrina
%A Dikov, Tihomir
%A Christova, Svetlana
%A Carracedo, Angel
%A Tretarre, Brigitte
%A Rebillard, Xavier
%A Mulot, Claire
%A Jan Adolfsson
%A Stattin, Par
%A Johansson, Jan-Erik
%A Martin, Richard M
%A Thompson, Ian M
%A Chambers, Suzanne
%A Aitken, Joanne
%A Horvath, Lisa
%A Haynes, Anne-Maree
%A Tilley, Wayne
%A Risbridger, Gail
%A Aly, Markus
%A Nordström, Tobias
%A Pharoah, Paul
%A Tammela, Teuvo L J
%A Murtola, Teemu
%A Auvinen, Anssi
%A Burnet, Neil
%A Barnett, Gill
%A Andriole, Gerald
%A Klim, Aleksandra
%A Drake, Bettina F
%A Borre, Michael
%A Kerns, Sarah
%A Ostrer, Harry
%A Zhang, Hong-Wei
%A Cao, Guangwen
%A Lin, Ji
%A Ling, Jin
%A Li, Meiling
%A Feng, Ninghan
%A Li, Jie
%A He, Weiyang
%A Guo, Xin
%A Sun, Zan
%A Wang, Guomin
%A Guo, Jianming
%A Southey, Melissa C
%A FitzGerald, Liesel M
%A Marsden, Gemma
%A Gómez-Caamaño, Antonio
%A Carballo, Ana
%A Peleteiro, Paula
%A Calvo, Patricia
%A Szulkin, Robert
%A Llorca, Javier
%A Dierssen-Sotos, Trinidad
%A Gomez-Acebo, Ines
%A Lin, Hui-Yi
%A Ostrander, Elaine A
%A Bisbjerg, Rasmus
%A Klarskov, Peter
%A Røder, Martin Andreas
%A Iversen, Peter
%A Holleczek, Bernd
%A Stegmaier, Christa
%A Schnoeller, Thomas
%A Bohnert, Philipp
%A John, Esther M
%A Ost, Piet
%A Teo, Soo-Hwang
%A Gamulin, Marija
%A Kulis, Tomislav
%A Kastelan, Zeljko
%A Slavov, Chavdar
%A Popov, Elenko
%A Van den Broeck, Thomas
%A Joniau, Steven
%A Larkin, Samantha
%A Castelao, Jose Esteban
%A Martinez, Maria Elena
%A van Schaik, Ron H N
%A Xu, Jianfeng
%A Lindström, Sara
%A Riboli, Elio
%A Berry, Clare
%A Siddiq, Afshan
%A Canzian, Federico
%A Kolonel, Laurence N
%A Le Marchand, Loic
%A Freedman, Matthew
%A Cenee, Sylvie
%A Sanchez, Marie
%T Germline variation at 8q24 and prostate cancer risk in men of European ancestry.
%J Nature Communications
%V 9
%N 1
%@ 2041-1723
%C [London]
%I Nature Publishing Group UK
%M DKFZ-2018-01955
%P 4616
%D 2018
%Z Collaborator: Canzian, F, C055
%X Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30397198
%2 pmc:PMC6218483
%R 10.1038/s41467-018-06863-1
%U https://inrepo02.dkfz.de/record/141684