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@ARTICLE{Matejcic:141684,
      author       = {M. Matejcic and E. J. Saunders and T. Dadaev and M. N.
                      Brook and K. Wang and X. Sheng and A. A. A. Olama and F. R.
                      Schumacher and S. A. Ingles and K. Govindasami and S.
                      Benlloch and S. I. Berndt and D. Albanes and S. Koutros and
                      K. Muir and V. L. Stevens and S. M. Gapstur and C. M. Tangen
                      and J. Batra and J. Clements and H. Gronberg and N. Pashayan
                      and J. Schleutker and A. Wolk and C. West and L. Mucci and
                      P. Kraft and G. Cancel-Tassin and K. D. Sorensen and L.
                      Maehle and E. M. Grindedal and S. S. Strom and D. E. Neal
                      and F. C. Hamdy and J. L. Donovan and R. C. Travis and R. J.
                      Hamilton and B. Rosenstein and Y.-J. Lu and G. G. Giles and
                      A. S. Kibel and A. Vega and J. T. Bensen and M. Kogevinas
                      and K. L. Penney and J. Y. Park and J. L. Stanford and C.
                      Cybulski and B. G. Nordestgaard and H. Brenner$^*$ and C.
                      Maier and J. Kim and M. R. Teixeira and S. L. Neuhausen and
                      K. De Ruyck and A. Razack and L. F. Newcomb and D. Lessel
                      and R. Kaneva and N. Usmani and F. Claessens and P. A.
                      Townsend and M. G. Dominguez and M. J. Roobol and F.
                      Menegaux and K.-T. Khaw and L. A. Cannon-Albright and H.
                      Pandha and S. N. Thibodeau and D. J. Schaid and F. Wiklund
                      and S. J. Chanock and D. F. Easton and R. A. Eeles and Z.
                      Kote-Jarai and D. V. Conti and C. A. Haiman and B. E.
                      Henderson and M. C. Stern and A. Thwaites and M. Guy and I.
                      Whitmore and A. Morgan and C. Fisher and S. Hazel and N.
                      Livni and M. Cook and L. Fachal and S. Weinstein and L. E.
                      Beane Freeman and R. N. Hoover and M. J. Machiela and A.
                      Lophatananon and B. D. Carter and P. Goodman and L. Moya and
                      S. Srinivasan and M.-A. Kedda and T. Yeadon and A. Eckert
                      and M. Eklund and C. Cavalli-Bjoerkman and A. M. Dunning and
                      C. Sipeky and N. Hakansson and R. Elliott and H. Ranu and E.
                      Giovannucci and C. Turman and D. J. Hunter and O. Cussenot
                      and T. F. Orntoft and A. Lane and S. J. Lewis and M. Davis
                      and T. J. Key and P. Brown and G. S. Kulkarni and A. R.
                      Zlotta and N. E. Fleshner and A. Finelli and X. Mao and J.
                      Marzec and R. J. MacInnis and R. Milne and J. L. Hopper and
                      M. Aguado and M. Bustamante and G. Castaño-Vinyals and E.
                      Gracia-Lavedan and L. Cecchini and M. Stampfer and J. Ma and
                      T. A. Sellers and M. S. Geybels and H. Park and B. Zachariah
                      and S. Kolb and D. Wokolorczyk and Jan Lubinski and W.
                      Kluzniak and S. F. Nielsen and M. Weisher and K. Cuk$^*$ and
                      W. Vogel and M. Luedeke and C. J. Logothetis and P. Paulo
                      and M. Cardoso and S. Maia and M. P. Silva and L. Steele and
                      Y. C. Ding and G. De Meerleer and S. De Langhe and H.
                      Thierens and J. Lim and M. H. Tan and A. T. Ong and D. W.
                      Lin and D. Kachakova and A. Mitkova and V. Mitev and M.
                      Parliament and G. Jenster and C. Bangma and F. H. Schroder
                      and T. Truong and Y. A. Koudou and A. Michael and A. Kierzek
                      and A. Karlsson and M. Broms and H. Wu and C. Aukim-Hastie
                      and L. Tillmans and S. Riska and S. K. McDonnell and D.
                      Dearnaley and A. Spurdle and R. Gardiner and V. Hayes and L.
                      Butler and R. Taylor and M. Papargiris and P. Saunders and
                      P. Kujala and K. Talala and K. Taari and S. Bentzen and B.
                      Hicks and A. Vogt and A. Hutchinson and A. Cox and A. George
                      and A. Toi and A. Evans and T. H. van der Kwast and T. Imai
                      and S. Saito and S.-C. Zhao and G. Ren and Y. Zhang and Y.
                      Yu and Y. Wu and J. Wu and B. Zhou and J. Pedersen and R.
                      Lobato-Busto and J. M. Ruiz-Dominguez and L. Mengual and A.
                      Alcaraz and J. Pow-Sang and K. Herkommer and A. Vlahova and
                      T. Dikov and S. Christova and A. Carracedo and B. Tretarre
                      and X. Rebillard and C. Mulot and Jan Adolfsson and P.
                      Stattin and J.-E. Johansson and R. M. Martin and I. M.
                      Thompson and S. Chambers and J. Aitken and L. Horvath and
                      A.-M. Haynes and W. Tilley and G. Risbridger and M. Aly and
                      T. Nordström and P. Pharoah and T. L. J. Tammela and T.
                      Murtola and A. Auvinen and N. Burnet and G. Barnett and G.
                      Andriole and A. Klim and B. F. Drake and M. Borre and S.
                      Kerns and H. Ostrer and H.-W. Zhang and G. Cao and J. Lin
                      and J. Ling and M. Li and N. Feng and J. Li and W. He and X.
                      Guo and Z. Sun and G. Wang and J. Guo and M. C. Southey and
                      L. M. FitzGerald and G. Marsden and A. Gómez-Caamaño and
                      A. Carballo and P. Peleteiro and P. Calvo and R. Szulkin and
                      J. Llorca and T. Dierssen-Sotos and I. Gomez-Acebo and H.-Y.
                      Lin and E. A. Ostrander and R. Bisbjerg and P. Klarskov and
                      M. A. Røder and P. Iversen and B. Holleczek and C.
                      Stegmaier and T. Schnoeller and P. Bohnert and E. M. John
                      and P. Ost and S.-H. Teo and M. Gamulin and T. Kulis and Z.
                      Kastelan and C. Slavov and E. Popov and T. Van den Broeck
                      and S. Joniau and S. Larkin and J. E. Castelao and M. E.
                      Martinez and R. H. N. van Schaik and J. Xu and S. Lindström
                      and E. Riboli and C. Berry and A. Siddiq and F. Canzian$^*$
                      and L. N. Kolonel and L. Le Marchand and M. Freedman and S.
                      Cenee and M. Sanchez},
      collaboration = {PRACTICAL},
      title        = {{G}ermline variation at 8q24 and prostate cancer risk in
                      men of {E}uropean ancestry.},
      journal      = {Nature Communications},
      volume       = {9},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2018-01955},
      pages        = {4616},
      year         = {2018},
      note         = {Collaborator: Canzian, F, C055},
      abstract     = {Chromosome 8q24 is a susceptibility locus for multiple
                      cancers, including prostate cancer. Here we combine genetic
                      data across the 8q24 susceptibility region from 71,535
                      prostate cancer cases and 52,935 controls of European
                      ancestry to define the overall contribution of germline
                      variation at 8q24 to prostate cancer risk. We identify 12
                      independent risk signals for prostate cancer
                      (p < 4.28 × 10-15), including three risk variants
                      that have yet to be reported. From a polygenic risk score
                      (PRS) model, derived to assess the cumulative effect of risk
                      variants at 8q24, men in the top $1\%$ of the PRS have a
                      4-fold $(95\%CI = 3.62-4.40)$ greater risk compared to
                      the population average. These 12 variants account for
                      $~25\%$ of what can be currently explained of the familial
                      risk of prostate cancer by known genetic risk factors. These
                      findings highlight the overwhelming contribution of germline
                      variation at 8q24 on prostate cancer risk which has
                      implications for population risk stratification.},
      cin          = {C070 / G110 / L101 / C055},
      ddc          = {500},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)G110-20160331 /
                      I:(DE-He78)L101-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30397198},
      pmc          = {pmc:PMC6218483},
      doi          = {10.1038/s41467-018-06863-1},
      url          = {https://inrepo02.dkfz.de/record/141684},
}