%0 Journal Article
%A Tejada Neyra, Miguel Angel
%A Neuberger, Ulf
%A Reinhardt, Annekathrin
%A Brugnara, Gianluca
%A Bonekamp, David
%A Sill, Martin
%A Wick, Antje
%A Jones, David
%A Radbruch, Alexander
%A Unterberg, Andreas
%A Debus, Jürgen
%A Heiland, Sabine
%A Schlemmer, Heinz-Peter
%A Herold-Mende, Christel
%A Pfister, Stefan
%A von Deimling, Andreas
%A Wick, Wolfgang
%A Capper, David
%A Bendszus, Martin
%A Kickingereder, Philipp
%T Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma.
%J Neuro-Oncology
%V 20
%N 11
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2018-01957
%P 1517 - 1524
%D 2018
%X This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma.A consecutive series of n = 237 patients with newly diagnosed glioblastoma and n = 131 patients with lower-grade glioma was analyzed. Volumetric tumor segmentation was performed on preoperative MRI with a semi-automated approach and images were registered to the standard Montreal Neurological Institute 152 space. Using a voxel-based lesion symptom mapping (VLSM) analysis, we identified specific brain regions that were associated with tumor-specific molecular alterations. We assessed a predefined set of n = 17 molecular characteristics in the glioblastoma cohort and n = 2 molecular characteristics in the lower-grade glioma cohort. Permutation adjustment (n = 1000 iterations) was used to correct for multiple testing, and voxel t-values that were greater than the t-value in >95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30107597
%2 pmc:PMC6176804
%R 10.1093/neuonc/noy134
%U https://inrepo02.dkfz.de/record/141686