TY  - JOUR
AU  - Tejada Neyra, Miguel Angel
AU  - Neuberger, Ulf
AU  - Reinhardt, Annekathrin
AU  - Brugnara, Gianluca
AU  - Bonekamp, David
AU  - Sill, Martin
AU  - Wick, Antje
AU  - Jones, David
AU  - Radbruch, Alexander
AU  - Unterberg, Andreas
AU  - Debus, Jürgen
AU  - Heiland, Sabine
AU  - Schlemmer, Heinz-Peter
AU  - Herold-Mende, Christel
AU  - Pfister, Stefan
AU  - von Deimling, Andreas
AU  - Wick, Wolfgang
AU  - Capper, David
AU  - Bendszus, Martin
AU  - Kickingereder, Philipp
TI  - Voxel-wise radiogenomic mapping of tumor location with key molecular alterations in patients with glioma.
JO  - Neuro-Oncology
VL  - 20
IS  - 11
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2018-01957
SP  - 1517 - 1524
PY  - 2018
AB  - This study aims to evaluate the impact of tumor location on key molecular alterations on a single voxel level in patients with newly diagnosed glioma.A consecutive series of n = 237 patients with newly diagnosed glioblastoma and n = 131 patients with lower-grade glioma was analyzed. Volumetric tumor segmentation was performed on preoperative MRI with a semi-automated approach and images were registered to the standard Montreal Neurological Institute 152 space. Using a voxel-based lesion symptom mapping (VLSM) analysis, we identified specific brain regions that were associated with tumor-specific molecular alterations. We assessed a predefined set of n = 17 molecular characteristics in the glioblastoma cohort and n = 2 molecular characteristics in the lower-grade glioma cohort. Permutation adjustment (n = 1000 iterations) was used to correct for multiple testing, and voxel t-values that were greater than the t-value in >95
LB  - PUB:(DE-HGF)16
C6  - pmid:30107597
C2  - pmc:PMC6176804
DO  - DOI:10.1093/neuonc/noy134
UR  - https://inrepo02.dkfz.de/record/141686
ER  -